In Vitro and In Vivo Studies on the Disposition of Mirtazapine in Humans

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

1977 • 1,196 citations

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

1980 • 544 citations

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1992 • 406 citations

EZ-FIT: A practical curve-fitting microcomputer program for the analysis of enzyme kinetic data on IBM-PC compatible computers

1988 • 268 citations

Cytochrome P450TB (CYP2C): A major monooxygenase catalyzing diclofenac 4′-hydroxylation in human liver

1993 • 258 citations

Determination of debrisoquine and its 4-hydroxy metabolite in biological fluids by gas chromatography with flame-ionization and nitrogen-selective detection

1977 • 155 citations

Polymorphic Drug Oxidation

1996 • 141 citations

Mirtazapine

1996 • 125 citations

S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin

1989 • 116 citations

Inhibition of desmethylimipramine 2-hydroxylation by drugs in human liver microsomes

1985 • 91 citations

The α2-selective adrenoceptor antagonist org 3770 (mirtazapine, Remeron®) enhances noradrenergic and serotonergic transmission

1995 • 83 citations

Metabolism of three pharmacologically active drugs in isolated human and rat hepatocytes: Analysis of interspecies variability and comparison with metabolismin vivo

1994 • 65 citations

Stereoselective disposition of mianserin is related to debrisoquin hydroxylation polymorphism

1994 • 54 citations

Human Cytochrome P450 Enzyme Selectivities in the Oxidation of Chlorinated Benzenes

1995 • 52 citations

Pharmacokinetic dose-proportionality study at steady state of mirtazapine from Remeron® tablets

1995 • 49 citations

The synthesis of org 3770 labelled with ³H, ¹³C AND ¹⁴C

1989 • 14 citations