The clinical application of tricyclic antidepressant pharmacokinetics and plasma levels

Psychopharmacology. A Generation of Progress

1978 • 668 citations

THE TREATMENT OF DEPRESSIVE STATES WITH G 22355 (IMIPRAMINE HYDROCHLORIDE)

1958 • 593 citations

Relationship between Plasma Level and Therapeutic Effect of Nortriptyline

1971 • 467 citations

Biogenic Amines and Depression

1975 • 361 citations

Steady-state plasma levels of nortriptyline in twins: Influence of genetic factors and drug therapy

1969 • 361 citations

The Efficacy of Antidepressant Drugs

1974 • 353 citations

Clinical Implications of Imipramine Plasma Levels for Depressive Illness

1977 • 322 citations

PLASMA CONCENTRATION OF AMITRIPTYLINE AND CLINICAL RESPONSE

1972 • 263 citations

Depression, Delusions, and Drug Response

1975 • 231 citations

Correlation of Subjective Side Effects with Plasma Concentrations of Nortriptyline

1970 • 203 citations

Cardiac Antiarrhythmic Effect of Imipramine Hydrochloride

1977 • 202 citations

Relationship between age and tricyclic antidepressant plasma levels

1977 • 196 citations

Amitriptyline plasma levels and therapeutic response

1976 • 194 citations

Tricyclic antidepressant overdose

1979 • 184 citations

Plasma protein binding of tricyclic anti-depressants in man

1969 • 184 citations

Imipramine: Clinical effects and pharmacokinetic variability

1977 • 176 citations

Drug Interaction: Inhibitory Effect of Neuroleptics on Metabolism of Tricyclic Antidepressants in Man

1972 • 176 citations

PLASMA-NORTRIPTYLINE LEVELS IN ENDOGENOUS DEPRESSION

1973 • 172 citations

Self-inhibiting action of nortriptylin's antidepressive effect at high plasma levels

1976 • 161 citations

Tricyclic antidepressant plasma levels and adverse effects after overdose

1977 • 153 citations

Tricyclic antidepressant overdose: incidence of symptoms

1977 • 150 citations

Depressive Typologies and Response to Amitriptyline

1972 • 149 citations

PLASMA CONCENTRATION OF NORTRIPTYLINE AND CLINICAL RESPONSE IN DEPRESSIVE ILLNESS

1972 • 138 citations

Tricyclic Antidepressant Overdose

1977 • 133 citations

A Potential Clinical Use for Methylphenidate with Tricyclic Antidepressants

1971 • 131 citations

Tricyclic Antidepressants

1978 • 129 citations

The effect of toxic and therapeutic doses of tricyclic antidepressant drugs on intracardiac conduction.

1975 • 124 citations

First‐pass metabolism of imipramine in man

1975 • 121 citations

AMITRIPTYLINE PLASMA-CONCENTRATION AND CLINICAL EFFECT

1978 • 118 citations

Pharmacokinetics of desmethylimipramine and nortriptyline in man after single and multiple oral doses ? A cross-over study

1972 • 112 citations

Cardiac Effects of Different Tricyclic Antidepressant Drugs

1976 • 112 citations

Nortriptyline plasma levels and therapeutic response

1976 • 103 citations

Imipramine-Induced Heart Block A Longitudinal Case Study

1975 • 98 citations

Electron beam ionization mass fragmentographic analysis of tricyclic antidepressants in human plasma

1976 • 97 citations

Amitriptyline plasma levels and clinical response in primary depression

1977 • 93 citations

Quantitative determination of imipramine and desipramine in human blood plasma by direct densitometry of thin-layer chromatograms

1973 • 87 citations

Tricyclic Plasma Levels

1977 • 86 citations

Influence of Neuroleptics and Benzodiazepines on Metabolism of Tricyclic Antidepressants in Man

1974 • 78 citations

First‐pass metabolism of nortriptyline in man

1975 • 78 citations

Liquid-chromatographic procedure for tricyclic drugs and their metabolites in plasma.

1978 • 68 citations

High plasma nortriptyline levels in the treatment of depression. I

1978 • 68 citations

New Evidence of Serotonin-Deficient Depressions

1977 • 64 citations

Gas-chromatographic analysis for therapeutic concentrations of amitriptyline and nortriptyline in plasma, with use of a nitrogen detector.

1976 • 64 citations

Plasma levels of imipramine and desipramine in man after different routes of administration

1975 • 63 citations

Plasma Concentrations of Protriptyline and Clinical Effects in Depressed Women

1976 • 60 citations

The availability of orally administered nortriptyline

1973 • 55 citations

Plasma nortriptyline levels and ECG findings

1977 • 52 citations

Doxepin kinetics

1978 • 51 citations

Treatment of Depression with Tricyclic Drugs – Pharmacokinetic and Pharmacodynamic Aspects^*

1976 • 49 citations

Nortriptyline in depressed patients with high plasma levels. II

1978 • 48 citations

First pass hydroxylation of nortriptyline: Concentrations of parent drug and major metabolites in plasma

1977 • 48 citations

Circulatory effects in man of nortriptyline, a tricyclic antidepressant drug

1970 • 46 citations

Routine nortriptyline levels in treatment of depression.

1977 • 43 citations

Tricyclic antidepressant drugs and cardiac conduction

1977 • 38 citations

Effects of perphenazine on imipramine metabolism in man.

1975 • 37 citations

Pharmacokinetic aspects of protriptyline plasma levels

1977 • 36 citations

Radioimmunoassay of imipramine and desmethylimipramine

1978 • 36 citations

Steady-state plasma concentrations during single and multiple dosage schedules of amitriptyline

1974 • 36 citations

A sensitive GLC method for the determination of imipramine and desmethylimipramine using a nitrogen detector.

1975 • 32 citations

Analysis of Tricyclic Antidepressants in Human Plasma by GLC–Chemical-Ionization Mass Spectrometry with Selected Ion Monitoring

1978 • 32 citations

Metabolism, anticholinergic effects, and therapeutic outcome of desmethylimipramine in depressive illness

1972 • 31 citations

Protriptyline plasma levels and antidepressant response

1977 • 27 citations

Plasma concentration of nortriptyline as a guide to treatment

1974 • 26 citations

Reduced levels of tricyclic antidepressants in plasma from Vacutainers.

1977 • 25 citations

Physiological and Pharmacokinetic Complexities in Bioavailability Testing

1972 • 23 citations

Protriptyline kinetics

1978 • 22 citations

A Comparison of Antidepressant Medications in Neurotic and Psychotic Patients

1975 • 21 citations

Specific radioimmunoassay of amitriptyline and nortriptyline.

1979 • 20 citations

On the biological half-life of amitriptyline

1976 • 19 citations

Determination of tricyclic antidepressant, clomipramine (Anafranil), in plasma by a specific radioimmunoassay procedure.

1978 • 19 citations

The Kinetics of Imipramine‐N‐Oxide in Man

1978 • 18 citations

Interactions between cardioactive drugs and antidepressants

1977 • 18 citations

Ophthalmological Effects of Nortriptyline – Relationship to Plasma Level

1972 • 18 citations

Tricyclic antidepressants and cardiac conduction: Changes in ventricular automaticity

1976 • 16 citations

Sampling Time, Dosage Schedule, and Nortriptyline Plasma Levels

1977 • 14 citations

Therapeutic Control of Plasma Concentrations and Long-term Effect of Nortriptyline in Recurrent Affective Disorders^*

1976 • 14 citations

Amitriptyline Nortriptyline Plasma Levels and Therapeutic Response in Depressed Women

1977 • 14 citations

The clinical impact of blood collection methods on tricyclic antidepressants as measured by GC/MS-SIM.

1978 • 13 citations

Drug plasma levels and clinical effect.

1971 • 13 citations

The kinetics of amitriptyline following single oral dose administration to man.

1978 • 13 citations

Specific radioimmunoassay for amitriptyline and nortriptyline in plasma.

1977 • 11 citations

Effect of Vacutainer stoppers on plasma tricyclic levels: a reevaluation.

1978 • 11 citations

A NEW ANTIDEPRESSANT BUTRIPTYLINE: PLASMA LEVELS AND CLINICAL RESPONSE

1977 • 8 citations

Imipramine and desipramine plasma levels: relationship to dosage schedule and sampling time.

1978 • 8 citations

Plasma levels of tricyclics, clinical response and drug interactions

1977 • 5 citations