The effect of sertraline on the pharmacokinetics of desipramine and imipramine

The effect of selective serotonin re‐uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes.

1992 • 456 citations

Polymorphic dextromethorphan metabolism: Co-segregation of oxidative O-demethylation with debrisoquin hydroxylation

1985 • 386 citations

Fluvoxamine is a potent inhibitor of cytochrome P4501A2

1993 • 370 citations

Antidepressant efficacy of sertraline: a double-blind, placebo- and amitriptyline-controlled, multicenter comparison study in outpatients with major depression.

1990 • 261 citations

The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes

1994 • 196 citations

Pharmacokinetics of Desipramine Coadministered With Sertraline or Fluoxetine

1994 • 191 citations

Inhibition by paroxetine of desipramine metabolism in extensive but not in poor metabolizers of sparteine

1993 • 189 citations

Quantification and mechanism of the fluoxetine and tricyclic antidepressant interaction

1992 • 168 citations

Inhibition of desipramine hydroxylation in vitro by serotonin-reuptake-inhibitor antidepressants, and by quinidine and ketoconazole: a model system to predict drug interactions in vivo.

1994 • 151 citations

First‐pass metabolism of imipramine in man

1975 • 121 citations

Clinical Pharmacokinetics of Imipramine and Desipramine

1990 • 112 citations

Sertraline 50 mg daily: the optimal dose in the treatment of depression

1995 • 91 citations

First-pass metabolism of imipramine and desipramine: Impact of the sparteine oxidation phenotype

1988 • 87 citations

Interethnic differences in drug metabolism: influence of genetic and environmental factors on debrisoquine hydroxylation phenotype

1996 • 82 citations

Interaction Between Fluvoxamine and Imipramine/Desipramine in Four Patients

1992 • 75 citations

Genetic Polymorphism of Sparteine/Debrisoquine Oxidation: A Reappraisal

1990 • 62 citations

Selective Serotonin Reuptake Inhibitors and Tricyclic Antidepressants in Combination

1995 • 50 citations

Selective serotonin reuptake inhibitor dose titration in the naturalistic setting.

1994 • 49 citations

Increased trimipramine plasma levels during fluvoxamine comedication

1994 • 33 citations

Imipramine demethylation in vivo: Impact of CYP1A2, CYP2C19, and CYP3A4*

1997 • 29 citations

Increased plasma tricyclic antidepressant concentrations in two patients concurrently treated with fluoxetine.

1989 • 25 citations

DNA haplotype dependency of debrisoquine 4-hydroxylase (CYP2D6) expression among extensive metabolisers

1993 • 12 citations

Increased plasma nortriptyline concentration in a patient cotreated with fluoxetine.

1990 • 9 citations