Clinical Pharmacokinetics of the Monoamine Oxidase-A Inhibitor Moclobemide*

A physiological approach to hepatic drug clearance

1975 • 1,855 citations

Some observations upon a new inhibitor of monoamine oxidase in brain tissue

1968 • 1,589 citations

Depression and Parkinson's disease: a review

1992 • 1,110 citations

The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it

1992 • 925 citations

X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism.

1993 • 363 citations

Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19- 6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain

1992 • 332 citations

HYPERTENSIVE CRISIS DUE TO MONOAMINE-OXIDASE INHIBITORS

1963 • 329 citations

Biochemistry and genetics of monoamine oxidase

1990 • 306 citations

Estimation of Variance for Harmonic Mean Half-Lives

1985 • 304 citations

Hypertensive Interactions Between Monoamine Oxidase Inhibitors and Foodstuffs

1967 • 259 citations

Neurochemical profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type A.

1989 • 195 citations

Monoamine oxidase, hydrogen peroxide, and Parkinson's disease.

1987 • 173 citations

On tyramine, food, beverages and the reversible MAO inhibitor moclobemide.

1988 • 171 citations

The new generation of monoamine oxidase inhibitors

1992 • 168 citations

Monoamine oxidase, brain ageing and degenerative diseases

1989 • 155 citations

Promoter organization and activity of human monoamine oxidase (MAO) A and B genes

1992 • 141 citations

Effects of Dopamine in Man

1962 • 141 citations

Interactions of monoamine oxidase with substrates and inhibitors

1989 • 141 citations

New directions in monoamine oxidase A and B selective inhibitors and substrates

1991 • 138 citations

Expression of monoamine oxidase B activity in astrocytes of senile plaques

1990 • 128 citations

Fluoxetine Drug-Drug Interactions

1990 • 128 citations

The Present Status of Monoamine Oxidase Inhibitors

1985 • 121 citations

Turnover of Brain Monoamine Oxidase Measured In Vivo by Positron Emission Tomography Using <scp>l</scp>‐[¹¹C]Deprenyl

1987 • 119 citations

The clearance of antipyrine and indocyanine green in normal subjects and in patients with chronic liver disease

1976 • 119 citations

Characterization of cimetidine, ranitidine, and related structures' interaction with cytochrome P-450.

1983 • 119 citations

Clinical experience with iproniazid (marsilid).

1958 • 117 citations

A review of the pharmacology of selegiline

1991 • 101 citations

Plasma 3, 4-dihydroxyphenylglycol (DHPG) and 3-methoxy-4- hydroxyphenylglycol (MHPG) are insensitive indicators of α2-adrenoceptor mediated regulation of norepinephrine release in healthy human volunteers

1991 • 95 citations

Assignment of genes for human monoamine oxidases A and B to the X chromosome

1986 • 92 citations

Evidence Found for a Possible 'Aggression Gene'

1993 • 91 citations

Modification by monoamine oxidase inhibitors of the effect of some sympathomimetics on blood pressure.

1967 • 88 citations

Monoamine oxidase inhibitors and L-dopa.

1970 • 77 citations

The reaction of phenylhydrazine with microsomal cytochrome P-450. Catalysis of heme modification.

1982 • 77 citations

Monoamine Oxidase Inhibitors and Narcotic Analgesics

1987 • 76 citations

Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine oxidase‐A inhibitors moclobemide and toloxatone, and assessment of their effect on psychometric performance in healthy subjects.

1990 • 75 citations

Inhibition of monoamine oxidase by moclobemide: effects on monoamine metabolism and secretion of anterior pituitary hormones and cortisol in healthy volunteers.

1989 • 69 citations

THE CLINICAL EFFECT OF ISONIAZID AND IPRONIAZID IN THE TREATMENT OF PULMONARY TUBERCULOSIS

1954 • 68 citations

Biotransformation of moclobemide in humans

1990 • 66 citations

Plasma dihydroxyphenylglycol for estimation of noradrenaline neuronal re-uptake in the sympathetic nervous system in vivo

1989 • 65 citations

An update of recent moclobemide interaction data

1993 • 63 citations

Absorption and disposition of moclobemide in patients with advanced age or reduced liver or kidney function

1990 • 62 citations

Amine oxidases and their endogenous substrates (with special reference to monoamine oxidase and the brain)

1987 • 62 citations

An update on the identity crisis of monoamine oxidase: new and old evidence for the independence of mao A and B

1985 • 60 citations

Determination and comparison of the pressor effect of tyramine during long-term moclobemide and tranylcypromine treatment in healthy volunteers

1989 • 56 citations

Interactions of moclobemide with concomitantly administered medication: evidence from pharmacological and clinical studies

1992 • 56 citations

Tyramine kinetics and pressor sensitivity during monoamine oxidase inhibition by selegiline

1989 • 53 citations

Determination of the new monoamine oxidase inhibitor moclobemide and three of its metabolites in biological fluids by high-performance liquid chromatography

1987 • 51 citations

Disposition kinetics of moclobemide, a monoamine oxidase-A enzyme inhibitor: Single and multiple dosing in normal subjects

1987 • 50 citations

Moclobemide excretion in human breast milk.

1990 • 50 citations

Effect of Moclobemide, a New Reversible Monoamine Oxidase Inhibitor, on Absorption and Pressor Effect of Tyramine

1988 • 48 citations

Interaction studies with moclobemide

1990 • 46 citations

FURTHER STUDIES ON IPRONIAZID PHOSPHATE

1956 • 45 citations

5-Hydroxyindole acetic acid and homovanillic acid in cerebrospinal fluid in manic-depressive psychosis and the effect of probenecid treatment

1973 • 45 citations

Moclobemide, a new reversible MAO inhibitor ? interaction with tyramine and tricyclic antidepressants in healthy volunteers and depressive patients

1986 • 43 citations

Monoamine Oxidase Inhibitor Interactions with

1991 • 35 citations

MAOIs and hypertensive crises: the role of OTC drugs.

1989 • 35 citations

Plasma 3,4-dihydroxyphenylglycol as a tool to assess the role of neuronal uptake in the anaesthetized rabbit

1989 • 33 citations

Interactions of levodopa with inhibitors of monoamine oxidase and L‐aromatic amino acid decarboxylase

1975 • 31 citations

Single-dose pharmacokinetics of the MAO-inhibitor moclobemide in man.

1984 • 31 citations

Noninvasive kinetic approach to the estimation of total hepatic blood flow and shunting in chronic liver disease—a hypothesis

1979 • 30 citations

Moclobemide treatment causes a substantial rise in the sparteine metabolic ratio. Danish University Antidepressant Group.

1993 • 30 citations

Differential response patterns to MAO inhibitors and tricyclics.

1984 • 28 citations

The interactions of hydrazine derivatives with rat-hepatic cytochrome P-450

1984 • 26 citations

Comparison of the pressor effect of tyramine after treatment with phenelzine and moclobemide in healthy male volunteers

1992 • 26 citations

Biochemical effects of high single doses of moclobemide in man: correlation with plasma concentrations

1992 • 25 citations

On tyramine, food, beverages and the reversible MAO inhibitor moclobemide.

1988 • 25 citations

Processes Regulating the Functional Activity of Brain 5-Hydroxytryptamine: Results of Animal Experimentation and Their Relevance to the Understanding and Treatment of Depression

1978 • 23 citations

Monoamine oxidase‐A: pharmacodynamics in humans of moclobemide, a reversible and selective inhibitor.

1994 • 23 citations

SAFETY OF MOCLOBEMIDE IN CLINICAL USE

1992 • 22 citations

Disposition Kinetics of Moclobemide, a New Mao‐A Inhibitor, in Subjects with Impaired Renal Function

1990 • 21 citations

Pharmacokinetics of oral moclobemide in healthy human subjects and effects on MAO-activity in platelets and excretion of urine monoamine metabolites

1985 • 21 citations

Turnover of monoamine oxidase B (MAO-B) in pig brain by positron emission tomography using 11C-L-deprenyl

1990 • 20 citations

Cimetidine alters the disposition kinetics of the monoamine oxidase-A inhibitor moclobemide

1991 • 20 citations

Inhibition of cytochrome P-450-dependent oxidation reactions by mao inhibitors in rat liver microsomes

1987 • 20 citations

Plasma moclobemide and metabolites: lack of correlation with clinical response and biogenic amines

1989 • 20 citations

Adverse Drug Reactions in Combined Tricyclic and MAOI Therapy

1986 • 19 citations

Moclobemide pharmacokinetics in depressed patients: Lack of age effect

1991 • 18 citations

Biochemical Effects of Antidepressant Treatment—Studies of Monoamine Metabolites in Cerebrospinal Fluid and Platelet [ ³ H]Imipramine Binding

2007 • 18 citations

The catalytic behaviour of monoamine oxidase

1987 • 18 citations

Interaction of moclobemide, a new reversible monoamine oxidase inhibitor with oral tyramine.

1988 • 17 citations

Switch in Treatment From Tricyclic Antidepressants to Moclobemide

1995 • 17 citations

Comparison of the pharmacokinetics of moclobemide in poor and efficient metabolizers of debrisoquine

1990 • 16 citations

Subarachnoid Hemorrhage Following Ephedrine and MAO Inhibitor

1965 • 15 citations

Inhibitory effect of tranylcypromine on hepatic drug metabolism in the rat

1982 • 13 citations

Tyramine content of preserved and fermented foods or condiments of Far Eastern cuisine

1992 • 12 citations

Potentiation of the pressor effect of oral and intravenous tyramine during administration of the selective MAO-A inhibitor moclobemide in healthy volunteers

1989 • 11 citations

Effect of food intake on the relative bioavailability of moclobemide (Ro 11-1163).

1988 • 10 citations

[Adverse drug reactions in combined treatment with tricyclic antidepressants and monoamine oxidase inhibitors].

1988 • 9 citations

UNALTERED IBUPROFEN-INDUCED FAECAL BLOOD LOSS UPON COADMINISTRATION OF MOCLOBEMIDE

1992 • 6 citations

Disposition and Clinical Effects of Moclobemide and Three of its Metabolites following Overdose

1993 • 6 citations

MAO Inhibitors in Psychiatric Therapy: Effects and Side Effects

2015 • 5 citations

Relationship between the terminal disposition half-life and mean residence time in multicompartment models.

1993 • 4 citations

Influence of moclobemide on ibuprofen-induced faecal blood loss

1992 • 4 citations

Pharmacokinetic and metabolic aspects of the moclobemide-food interaction

1992 • 4 citations

Pharmacokinetics of moclobemide (Ro 11-1163) in patients with liver cirrhosis

1988 • 1 citations

CLINICAL PHARMACOLOGY OF REVERSIBLE MAO-A INHIBITORS

1992 • 1 citations

Deleted Work

1955 • 0 citations