Genetic and Molecular Markers of Urothelial Premalignancy and Malignancy

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors

1992 • 3,344 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1995 • 1,500 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

1982 • 1,398 citations

Identification of p53 Gene Mutations in Bladder Cancers and Urine Samples

1991 • 891 citations

Accumulation of Nuclear p53 and Tumor Progression in Bladder Cancer

1994 • 828 citations

Diagnostic Cytology and Its Histopathologic Bases.

1968 • 772 citations

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

1996 • 746 citations

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1996 • 654 citations

EPIDERMAL-GROWTH-FACTOR RECEPTORS IN HUMAN BLADDER CANCER: COMPARISON OF INVASIVE AND SUPERFICIAL TUMOURS

1985 • 611 citations

Two molecular pathways to transitional cell carcinoma of the bladder.

1994 • 599 citations

Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia.

1995 • 549 citations

Nuclear Overexpression of p53 Protein in Transitional Cell Bladder Carcinoma: A Marker for Disease Progression

1993 • 544 citations

The Role of Adjuvant Chemotherapy Following Cystectomy for Invasive Bladder Cancer: A Prospective Comparative Trial

1991 • 542 citations

Detection and Clinical Importance of Micrometastatic Disease

1999 • 505 citations

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

1995 • 491 citations

p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer.

1993 • 464 citations

Angiogenesis in Bladder Cancer: Relationship Between Microvessel Density and Tumor Prognosis

1995 • 430 citations

Drug-target interactions: only the first step in the commitment to a programmed cell death?

1991 • 412 citations

Cooperative tumorigenic effects of germline mutations in Rb and p53

1994 • 374 citations

Loss of genes on the short arm of chromosome 11 in bladder cancer

1985 • 360 citations

The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53

1998 • 357 citations

The epidermal growth factor receptor and the prognosis of bladder cancer

1990 • 351 citations

Altered Expression of the Retinoblastoma Gene Product: Prognostic Indicator in Bladder Cancer

1992 • 348 citations

Thrombospondin-1 Expression in Bladder Cancer: Association With p53 Alterations, Tumor Angiogenesis, and Tumor Progression

1997 • 328 citations

Allelic losses of chromosomes 9, 11, and 17 in human bladder cancer.

1990 • 327 citations

Epidemiology and etiology of bladder cancer

1997 • 322 citations

Elevated and Absent pRb Expression is Associated With Bladder Cancer Progression and has Cooperative Effects With p53

1998 • 317 citations

Effect of p21WAF1/CIP1 Expression on Tumor Progression in Bladder Cancer

1998 • 309 citations

Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents.

1996 • 298 citations

PROGNOSTIC MARKERS IN BLADDER CANCER: A CONTEMPORARY REVIEW OF THE LITERATURE

1998 • 285 citations

Frequent association of p53 gene mutation in Invasive bladder cancer

1992 • 265 citations

Prognostic value of p53 nuclear overexpression in patients with invasive bladder cancer treated with neoadjuvant MVAC.

1995 • 259 citations

Allelic loss of chromosome 17p distinguishes high grade from low grade transitional cell carcinomas of the bladder.

1990 • 252 citations

p53 mutations in human bladder cancer: Genotypicversus phenotypic patterns

1994 • 250 citations

Marked genetic differences between stage pTa and stage pT1 papillary bladder cancer detected by comparative genomic hybridization.

1997 • 250 citations

Genetic alterations in bladder cancer

1993 • 243 citations

Molecular genetic alterations in superficial and locally advanced human bladder cancer.

1991 • 233 citations

Numerical chromosome 1, 7, 9, and 11 aberrations in bladder cancer detected by in situ hybridization.

1991 • 233 citations

Cooperative effects of p53 and pRB alterations in primary superficial bladder tumors.

1997 • 222 citations

Association of P53 Nuclear Overexpression and Tumor Progression in Carcinoma in situ of the Bladder

1994 • 221 citations

Centromeric copy number of chromosome 7 is strongly correlated with tumor grade and labeling index in human bladder cancer.

1991 • 199 citations

Altered Patterns of MDM2 and TP53 Expression in Human Bladder Cancer

1994 • 192 citations

Frequency of molecular alterations affecting ras protooncogenes in human urinary tract tumors.

1985 • 191 citations

Clinical implications of the expression of epidermal growth factor receptors in human transitional cell carcinoma.

1990 • 185 citations

Deletion of the p16 and p15 Genes in Human Bladder Tumors

1995 • 185 citations

Inactivation of the retinoblastoma gene in human bladder and renal cell carcinomas.

1991 • 184 citations

Loss of heterozygosity at the RB locus is frequent and correlates with muscle invasion in bladder carcinoma.

1991 • 177 citations

Nonrandom chromosomal changes in transitional cell carcinoma of the bladder.

1984 • 172 citations

Role of chromosome 9 in human bladder cancer.

1993 • 166 citations

Cytokeratin 20 as an objective marker of urothelial dysplasia

1996 • 164 citations

Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the RB locus and tumor progression

1993 • 159 citations

An immunohistologic evaluation of C-erbB-2 gene product in patients with urinary bladder carcinoma

1992 • 153 citations

Chromosome 9 allelic losses and microsatellite alterations in human bladder tumors.

1994 • 147 citations

Expression of Epidermal Growth Factor Receptor in Invasive Transitional Cell Carcinoma of the Urinary Bladder:A Multivariate Survival Analysis

1994 • 133 citations

C-erbB-2 gene amplification: a molecular marker in recurrent bladder tumors?

1995 • 127 citations

Molecular alterations in bladder cancer

1998 • 119 citations

Genetic evidence in melanoma and bladder cancers that p16 and p53 function in separate pathways of tumor suppression.

1995 • 118 citations

Accumulated allelic losses in the development of invasive urothelial cancer

1993 • 115 citations

Concurrent mutations of coding and regulatory sequences of the Ha-ras gene in urinary bladder carcinomas

1992 • 110 citations

Cytogenetic study of ten carcinomas of the bladder: Involvement of chromosomes 1 and 11

1985 • 109 citations

Preliminary mapping of the deleted region of chromosome 9 in bladder cancer.

1993 • 104 citations

Alterations in phenotypic biochemical markers in bladder epithelium during tumorigenesis.

1993 • 100 citations

p53 immunohistochemistry in transitional cell carcinoma and dysplasia of the urinary bladder correlates with disease progression

1993 • 94 citations

Identification of H-ras Mutations in Urine Sediments Complements Cytology in the Detection of Bladder Tumors

1995 • 93 citations

Patterns of p53, erbB-2, and EGF-r expression in premalignant lesions of the urinary bladder*1

1995 • 86 citations

Reproducibility of p53 immunohistochemistry in bladder tumors. National Cancer Institute, Bladder Tumor Marker Network.

2000 • 83 citations

Tumor behavior in transitional cell carcinoma of the bladder in relation to chromosomal markers and histopathology.

1987 • 75 citations

Cytogenetic investigation on 30 bladder carcinomas

1988 • 73 citations

Dysplasia in normal-looking urothelium increases the risk of tumour progression in primary superficial bladder cancer

1994 • 71 citations

Bladder cancer risk assessment with quantitative fluorescence image analysis of tumor markers in exfoliated bladder cells

1993 • 70 citations

Physical deletion of the p53 gene in bladder cancer. Detection by fluorescence in situ hybridization.

1994 • 69 citations

Familial Transitional Cell Carcinoma

1996 • 64 citations

Ha-ras gene codon 12 mutation and DNA ploidy in urinary bladder carcinoma

1990 • 62 citations

Bladder irrigation specimens assayed by fluorescence in situ hybridization to interphase nuclei

1994 • 62 citations

Genetic studies and molecular markers of bladder cancer

1997 • 58 citations

P53 accumulation in precursor lesions and early stages of bladder cancer

1994 • 47 citations

Molecular determinants of outcome in bladder cancer.

1999 • 46 citations

Point Mutations of c‐ras Genes in Human Bladder Cancer and Kidney Cancer

1990 • 42 citations

Genotypic and phenotypic characterization of the histoblood group ABO(H) in primary bladder tumors

1998 • 39 citations

Cytogenetic Studies of Carcinoma in Situ of the Bladder: Prognostic Implications

1992 • 38 citations

Low-frequency mutation of Ha-ras and Ki-ras oncogenes in transitional cell carcinoma of the bladder.

1998 • 32 citations

Genetic alterations associated with bladder cancer.

1994 • 24 citations

Expression of mdm-2 and p53 protein in transitional cell carcinoma

1995 • 22 citations

HA-RAS CODON 12 MUTATION IN PAPILLARY TUMORS OF THE URINARY-BLADDER - A RETROSPECTIVE STUDY

1994 • 18 citations

Pathology of Bladder Cancer

1998 • 14 citations

Pathology of epithelial tumors & carcinoma in situ of bladder.

1984 • 13 citations

Screening of human bladder carcinomas for the presence of Ha-ras codon 12 mutation.

2000 • 12 citations

A mapping of histology and cell proliferation in human bladder cancer: an immunohistochemical study.

1995 • 6 citations