Expression of mdm-2 and p53 protein in transitional cell carcinoma

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

1993 • 565 citations

The tnm classification of malignant tumors

1988 • 544 citations

p53 Mutation and MDM2 amplification in human soft tissue sarcomas.

1993 • 535 citations

Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas.

1994 • 512 citations

A comparison of the biological activities of wild‐type and mutant p53

1993 • 423 citations

MDM2 gene amplification in metastatic osteosarcoma.

1993 • 340 citations

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.

1993 • 321 citations

Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes.

1993 • 193 citations

Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours.

1993 • 114 citations

mdm2 gene alterations and mdm2 protein expression in breast carcinomas

1995 • 104 citations

p53 protein expression in non‐neoplastic lesions and benign and malignant neoplasms of soft tissue

1993 • 95 citations

The mdm-2 Oncogene Can Overcome Wild-Type p53 Suppression of Transformed Cell Growth

1993 • 84 citations

p53 gene mutations and MDM2 amplification are uncommon in primary carcinomas of the uterine cervix.

1993 • 70 citations

Abnormal expression of the p53-binding protein MDM2 in Hodgkin's disease

1994 • 46 citations

Absence of amplification of MDM2 gene, a regulator of p53 function, in myelodysplastic syndromes.

1993 • 23 citations

Immunohistochemical evidence of abnormal expression of MDM2 and p53 in Hodgkin's disease

1995 • 1 citations