PROGNOSTIC MARKERS IN BLADDER CANCER: A CONTEMPORARY REVIEW OF THE LITERATURE

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Angiogenic Factors

1987 • 3,702 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation

1983 • 2,745 citations

Thalidomide is an inhibitor of angiogenesis.

1994 • 2,460 citations

Clinical Applications of Research on Angiogenesis

1995 • 2,300 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Cancer statistics, 1997

1997 • 2,045 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma

1992 • 1,799 citations

Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma.

1993 • 1,646 citations

The cadherins: cell-cell adhesion molecules controlling animal morphogenesis

1988 • 1,626 citations

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

1991 • 1,592 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

Angiostatin induces and sustains dormancy of human primary tumors in mice

1996 • 1,193 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

p53-Independent Expression of p21 ^Cip1 in Muscle and Other Terminally Differentiating Cells

1995 • 1,058 citations

TUMOR DORMANCY IN VIVO BY PREVENTION OF NEOVASCULARIZATION

1972 • 898 citations

Accumulation of Nuclear p53 and Tumor Progression in Bladder Cancer

1994 • 828 citations

Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer

1992 • 822 citations

Aberrant glycosylation in cancer cell membranes as focused on glycolipids: overview and perspectives.

1985 • 809 citations

Structural Evidence for the Authenticity of the Human Retinoblastoma Gene

1987 • 809 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

The Product of the Human c- erb B-2 Gene: a 185-Kilodalton Glycoprotein with Tyrosine Kinase Activity

1986 • 805 citations

Induction of WAF1/CIP1 by a p53-independent pathway.

1994 • 773 citations

Tumor Growth and Neovascularization: An Experimental Model Using the Rabbit Cornea 2

1974 • 762 citations

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

1996 • 746 citations

Inhibition of Angiogenesis In Vivo by Interleukin 12

1995 • 734 citations

THE myc ONCOGENE: ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION

1986 • 714 citations

DIOGENES SYNDROME

1975 • 685 citations

Role of integrins and other cell adhesion molecules in tumor progression and metastasis.

1993 • 668 citations

Monoclonal antibody Ki‐67: its use in histopathology

1990 • 655 citations

M-Vac (Methotrexate, Vinblastine, Doxorubicin and Cisplatin) for Advanced Transitional Cell Carcinoma of the Urothelium

1988 • 631 citations

EPIDERMAL-GROWTH-FACTOR RECEPTORS IN HUMAN BLADDER CANCER: COMPARISON OF INVASIVE AND SUPERFICIAL TUMOURS

1985 • 611 citations

Tumor interactions with the vasculature: angiogenesis and tumor metastasis

1990 • 598 citations

Growth of Multicell Spheroids in Tissue Culture as a Model of Nodular Carcinomas<xref ref-type="fn" rid="FN2">2</xref>

1971 • 580 citations

Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia.

1995 • 549 citations

Nuclear Overexpression of p53 Protein in Transitional Cell Bladder Carcinoma: A Marker for Disease Progression

1993 • 544 citations

The prognostic significance of tumor vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma. A quantitative histologic study.

1988 • 538 citations

Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells.

1983 • 484 citations

Elevated Levels of an Angiogenic Peptide, Basic Fibroblast Growth Factor, in the Urine of Patients With a Wide Spectrum of Cancers

1994 • 478 citations

p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer.

1993 • 464 citations

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

1991 • 446 citations

Angiogenesis in Bladder Cancer: Relationship Between Microvessel Density and Tumor Prognosis

1995 • 430 citations

Predictors of pathologic stage in prostatic carcinoma. The role of neovascularity

1994 • 416 citations

Induction of neovascularization in vivo and endothelial proliferation in vitro by tumor-associated macrophages.

1984 • 366 citations

The role of c-myc in cell growth

1993 • 365 citations

Decreased E-cadherin immunoreactivity correlates with poor survival in patients with bladder tumors.

1993 • 362 citations

Epidermal growth factor receptors

1981 • 352 citations

The epidermal growth factor receptor and the prognosis of bladder cancer

1990 • 351 citations

Altered Expression of the Retinoblastoma Gene Product: Prognostic Indicator in Bladder Cancer

1992 • 348 citations

p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity.

1986 • 341 citations

Use of a New Tumor Marker, Urinary NMP22, in the Detection of Occult or Rapidly Recurring Transitional Cell Carcinoma of the Urinary Tract Following Surgical Treatment

1996 • 330 citations

Thrombospondin-1 Expression in Bladder Cancer: Association With p53 Alterations, Tumor Angiogenesis, and Tumor Progression

1997 • 328 citations

Immunohistochemical detection of proliferating cell nuclear antigen in solid human malignancies.

1987 • 304 citations

Different angiogenic pathways characterize superficial and invasive bladder cancer.

1995 • 293 citations

Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro.

1991 • 273 citations

Over‐expression of p53 nuclear oncoprotein in transitional‐cell bladder cancer and its prognostic value

1993 • 264 citations

Prognostic value of p53 nuclear overexpression in patients with invasive bladder cancer treated with neoadjuvant MVAC.

1995 • 259 citations

Quantification of angiongenesis as an independent predictor of prognosis in invasive bladder carcinomas

1994 • 258 citations

Altered Expression of Retinoblastoma Protein and Known Prognostic Variables in Locally Advanced Bladder Cancer

1992 • 254 citations

p53 mutations in human bladder cancer: Genotypicversus phenotypic patterns

1994 • 250 citations

Tumor Behavior in Isolated Perfused Organs

1966 • 247 citations

Expression of epidermal growth factor receptor in bladder cancer as related to established prognostic factors, oncoprotein (c-erbB-2, p53) expression and long-term prognosis

1994 • 247 citations

Elevated Levels of the Angiogenic Peptide Basic Fibroblast Growth Factor in Urine of Bladder Cancer Patients

1993 • 246 citations

Molecular genetic alterations in superficial and locally advanced human bladder cancer.

1991 • 233 citations

Tumor Angiogenesis Correlates with Lymph Node Metastases in Invasive Bladder Cancer

1995 • 232 citations

Results of a Multicenter Trial using the BTA Test to Monitor for and Diagnose Recurrent Bladder Cancer

1995 • 231 citations

Angiostatin: A Circulating Endothelial Cell Inhibitor That Suppresses Angiogenesis and Tumor Growth

1994 • 219 citations

The Petinoblastoma Tumor Suppressor Protein

1994 • 215 citations

c-myc amplification is a better prognostic factor than HER2/neu amplification in primary breast cancer.

1992 • 212 citations

Interaction of integrins alpha 3 beta 1 and alpha 2 beta 1: potential role in keratinocyte intercellular adhesion.

1993 • 210 citations

Diagnosis and Management of Genitourinary Cancer

1988 • 209 citations

Prognostic value of cadherin-associated molecules (alpha-, beta-, and gamma-catenins and p120cas) in bladder tumors.

1996 • 209 citations

Acidic fibroblast growth factor is a modulator of epithelial plasticity in a rat bladder carcinoma cell line.

1990 • 208 citations

Diagnosis and Management of Genitourinary Cancer

1988 • 208 citations

Expression and Characterization of the Human c-myc DNA-Binding Protein

1985 • 205 citations

Antigenic Deletion and Prognosis of Patients with Stage a Transitional Cell Bladder Carcinoma

1975 • 205 citations

Improved detection of recurrent bladder cancer using the bard bta stat test

1997 • 195 citations

Altered Patterns of MDM2 and TP53 Expression in Human Bladder Cancer

1994 • 192 citations

ERBB2 amplification in breast cancer with a high rate of proliferation.

1991 • 191 citations

Clinical implications of the expression of epidermal growth factor receptors in human transitional cell carcinoma.

1990 • 185 citations

Inactivation of the retinoblastoma gene in human bladder and renal cell carcinomas.

1991 • 184 citations

Loss of heterozygosity at the RB locus is frequent and correlates with muscle invasion in bladder carcinoma.

1991 • 177 citations

Evaluation of epidermal growth factor receptors in bladder tumours

1987 • 168 citations

Philip Levine Award Lecture: Blood Group Antigens as Markers for Normal Differentiation and Malignant Change in Human Tissues

1987 • 167 citations

Tissue Blood-Group Antigens and Prognosis in Low Stage Transitional Cell Carcinoma of the Bladder

1978 • 161 citations

Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the RB locus and tumor progression

1993 • 159 citations

An immunohistologic evaluation of C-erbB-2 gene product in patients with urinary bladder carcinoma

1992 • 153 citations

Urinary Nuclear Matrix Protein as a Marker for Transitional Cell Carcinoma of the Urinary Tract

1996 • 147 citations

Increased levels of fibroblast growth factor-like activity in urine from patients with bladder or kidney cancer.

1988 • 146 citations

HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor.

1989 • 144 citations

A, B, H antigens in transitional cell tumors of the urinary bladder.Correlation with the clinical course

1979 • 141 citations

Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas.

1994 • 140 citations

Clinical evaluation of the BTA trak assay and comparison to voided urine cytology and the bard BTA test in patients with recurrent bladder tumors

1997 • 139 citations

RAPID PROTECTION OF BLADDER CANCER: A COMPARATIVE STUDY OF POINT OF CARE TESTS

1997 • 129 citations

C-erbB-2 gene amplification: a molecular marker in recurrent bladder tumors?

1995 • 127 citations

Secreted or nonsecreted forms of acidic fibroblast growth factor produced by transfected epithelial cells influence cell morphology, motility, and invasive potential.

1991 • 124 citations

C-ERBB-2 in Bladder Cancer: Molecular Biology, Correlation with Epidermal Growth Factor Receptors and Prognostic Value

1996 • 123 citations

Expression and characterization of the human c-myc DNA-binding protein.

1985 • 120 citations

Epidermal Growth Factor—Interactions with Normal and Malignant Urothelium: In Vivo and in Situ Studies

1987 • 118 citations

Increased Immunodetection of Acidic Fibroblast Growth Factor in Bladder Cancer, Detectable in Urine

1993 • 114 citations

Molecular aspects of chemical carcinogenesis: The roles of oncogenes and tumour suppressor genes

1995 • 110 citations

Incidence of Apoptosis, Cell Proliferation and bcl-2 Expression in Transitional Cell Carcinoma of the Bladder: Association with Tumor Progression

1996 • 110 citations

E‐cadherin expression in bladder cancer using formalin‐fixed, paraffin‐embedded tissues: Correlation with histopathological grade, tumour stage and survival

1995 • 110 citations

Expression of C-ERBB-2 Gene Product in Urinary Bladder Cancer

1991 • 109 citations

Prognostic factors in bladder carcinoma: Histologic parameters and expression of a cell cycle‐related nuclear antigen (Ki‐67)

1992 • 108 citations

Cell Surface A, B or O(H) Blood Group Antigens as an Indicator of Malignant Potential in Stage A Bladder Carcinoma

1980 • 107 citations

Enhanced Bladder Cancer Detection with the Lewis X Antigen as a Marker of Neoplastic Transformation

1990 • 105 citations

Initial Evaluation of the Bladder Tumor Antigen Test in Superficial Bladder Cancer

1996 • 102 citations

Reduced expression of E-cadherin is related to invasive disease and frequent recurrence in bladder cancer

1995 • 101 citations

Growth Fractions of Transitional Cell Carcinomas of the Bladder Defined by the Monoclonal Antibody KI-67

1990 • 99 citations

Oncogene Amplification in Urothelial Cancers With p53 Gene Mutation or MDM2 Amplification

1994 • 97 citations

Cell adhesion molecules in bladder cancer: soluble serum E-cadherin correlates with predictors of recurrence

1996 • 96 citations

Expression of transfected transforming growth factor alpha induces a motile fibroblast-like phenotype with extracellular matrix-degrading potential in a rat bladder carcinoma cell line.

1990 • 95 citations

Epidermal‐growth‐factor‐receptor expression is associated with rapid tumor proliferation in bladder cancer

1994 • 95 citations

Transforming growth factor‐β: An important mediator of immunoregulation

1991 • 94 citations

Expression of multidrug resistance-associated protein (MRP), MDR1 and DNA topoisomerase II in human multidrug-resistant bladder cancer cell lines

1995 • 93 citations

Urinary bladder cancer: mechanisms of development and progression.

1994 • 93 citations

Regressing thin cutaneous malignant melanomas (< or = 1.0 mm) are associated with angiogenesis.

1993 • 92 citations

Proliferation in human bladder carcinoma measured by Ki-67 antibody labelling: its potential clinical importance

1991 • 91 citations

Role of myc amplification and overexpression in cell growth, differentiation and death.

1993 • 90 citations

Evaluation of epidermal growth factor receptor, transforming growth factor alpha, epidermal growth factor and c-erbB2 in the progression of invasive bladder cancer

1997 • 89 citations

Blood group-related antigens in human urothelium: enhanced expression of precursor, LeX, and LeY determinants in urothelial carcinoma.

1988 • 84 citations

Transforming Growth Factors-beta 1 and beta 2 in Serum and Urine from Patients with Bladder Carcinoma

1996 • 82 citations

Comparison of five histopathologic methods to assess cellular proliferation in transitional cell carcinoma of the urinary bladder

1993 • 78 citations

Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1.

1995 • 77 citations

Epidermal growth factor and transforming growth factor-alpha in the development of epithelial-mesenchymal organs of the mouse.

1990 • 77 citations

Soluble forms of the adhesion molecule E-cadherin in urine.

1995 • 75 citations

Detection of bladder tumors by immunostaininc of the lewis x antigen in cells from voided urine

1995 • 75 citations

Cellular Adhesion Molecules in Urologic Malignancies

1997 • 75 citations

Cell Proliferation of Human Bladder Tumors Determined by Brdurd and Ki-67 Immunostaining

1991 • 74 citations

Immunoanatomic distribution of blood group antigens in the human urinary tract. Influence of secretor status.

1986 • 71 citations

Monoclonal Antibody Ki-67 in the Study of the Proliferative Activity of Bladder Carcinoma

1992 • 71 citations

THE BLADDER TUMOR ANTIGEN (BTA) TEST COMPARED TO VOIDED URINE CYTOLOGY IN THE DETECTION OF BLADDER NEOPLASMS

1997 • 70 citations

Loss of co-localization of alpha 6 beta 4 integrin and collagen VII in bladder cancer.

1994 • 69 citations

p53 anderbB-2 protein overexpression are associated with early invasion and metastasis in bladder cancer

1993 • 68 citations

Clinical significance of multi-drug resistance associated protein and P-glycoprotein in patients with bladder cancer.

1997 • 68 citations

Clinical cancer progression in urinary bladder tumors evaluated by multiparameter flow cytometry with monoclonal antibodies. Laval University Urology Group.

1990 • 68 citations

Urinary basic fibroblast growth factor in patients with bladder cancer and benign prostatic hypertrophy

1995 • 67 citations

Blood group isoantigen deletion in carcinomain situ of the urinary bladder

1979 • 67 citations

Aberrant RB gene expression in routinely processed, archival tumor tissues determined by three different anti‐RB antibodies

1994 • 66 citations

E-cadherin expression in papillary transitional cell carcinoma of the urinary bladder*1

1995 • 66 citations

Proto-Oncogenes and Tumor Suppressor Genes in Human Urological Malignancies

1994 • 65 citations

Expression of c‐myc protein is related to cell proliferation and expression of growth factor receptors in transitional cell bladder cancer

1995 • 64 citations

Expression of the VLA beta 1 integrin family in bladder cancer.

1994 • 63 citations

Ha-ras gene codon 12 mutation and DNA ploidy in urinary bladder carcinoma

1990 • 62 citations

Expression of c-erbB-2 oncoprotein in transitional cell bladder cancer

1993 • 62 citations

2 Epidermal Growth Factor and Transforming Growth Factor-α in the Development of Epithelial—Mesenchymal Organs of the Mouse

1990 • 59 citations

The Prognostic Value of Cell Surface Antigens in Low Grade, Non-Invasive, Transitional Cell Carcinoma of the Bladder

1979 • 58 citations

Identification of epidermal growth factor as a component of the rat urinary bladder tumor-enhancing urinary fractions.

1989 • 56 citations

Comparison of P53 protein overexpression with P53 mutation in bladder cancer: clinical and biologic aspects.

1995 • 56 citations

Clinical Significance of Multi-Drug Resistance Associated Protein and P-Glycoprotein in Patients with Bladder Cancer

1997 • 53 citations

Detection of the c‐myc Gene Product in Urinary Bladder Cancer

1990 • 52 citations

c-myc gene amplification in selected node-negative breast cancer patients correlates with high rate of early relapse

1992 • 51 citations

Expression of transforming growth factors beta-1, beta 2 and beta 3 in human bladder carcinomas

1997 • 50 citations

Evaluation of c-RAS Oncogene Product (p21 ) in Superficial Bladder Cancer

1996 • 50 citations

Molecular and immunohistochemical evaluation of epidermal growth factor receptor and c-erb-B-2 gene product in transitional cell carcinomas of the urinary bladder: a study in Greek patients.

1995 • 49 citations

Epidermal Growth Factor Receptor in Human Bladder Cancer: A Comparison of Immunohistochemistry and Ligand Binding

1989 • 48 citations

Expression of transforming growth factor-beta 1 in human bladder cancer

1995 • 47 citations

Critical appraisal of tumor markers in bladder cancer.

1993 • 46 citations

Correlation between integrin alpha 5 expression and the malignant phenotype of transitional cell carcinoma

1996 • 45 citations

Transforming growth factor alpha and epidermal growth factor levels in bladder cancer and their relationship to epidermal growth factor receptor

1996 • 45 citations

Point Mutations of c‐ras Genes in Human Bladder Cancer and Kidney Cancer

1990 • 42 citations

9 Tumour angiogenesis

1993 • 40 citations

Genitourinary Cancer Management

1987 • 39 citations

Qui doit nourrir l'enfant de parents non mariés ou démariés ?

1997 • 39 citations

Reduced expression of TGF β is associated with advanced disease in transitional cell carcinoma

1993 • 38 citations

Immunoperoxidase Detection of Carcinoembryonic Antigen and Blood Group Substances in Papillary Transitional Cell Carcinoma of the Bladder

1982 • 38 citations

The Monoclonal Antibody BQ16 Identifies the α6β4 Integrin on Bladder Cancer

1993 • 38 citations

Gene amplification detected in carcinoma cells from human urinary bladder washings by the polymerase chain reaction method

1993 • 37 citations

ABH Isoantigens in Stage O Papillary Transitional Cell Carcinoma of the Bladder: Correlation with Biological Behavior

1982 • 37 citations

Immunohistochemical detection of thrombospondin-1 in formalin-fixed, paraffin-embedded tissue.

1996 • 36 citations

Recovery of epidermal growth factorin voided urine of patients with bladder cancer

1994 • 35 citations

Defective E-cadherin function in urological cancers: clinical implications and molecular mechanisms.

1994 • 34 citations

Epidermal Growth Factor in Urine from Patients with Urinary Bladder Tumors

1988 • 33 citations

Urinary epidermal growth factor concentrations in various human malignancies

1988 • 31 citations

Evaluation of Multiple Drug Resistance in Human Bladder Cancer Cell Lines

1993 • 29 citations

DEFINING THE IDEAL TUMOR MARKER FOR PROSTATE CANCER

1997 • 26 citations

Correlation between the Expression of P-Glycoprotein and Multidrug-Resistant Phenotype in Transitional Cell Carcinoma of the Urinary Tract

1992 • 25 citations

Epidermal Growth Factor in Urine from the Patients with Urothelial Tumors

1992 • 25 citations

Effect of urine on clonal growth of human bladder cancer cell lines.

1991 • 23 citations

Epidermal growth factor and its receptor: Markers of— and targets for—chemoprevention of bladder cancer

1992 • 21 citations

Proliferating cell nuclear antigen: Cyclin

1987 • 20 citations

Tumor suppressor gene alterations in bladder carcinoma. Translational correlates to clinical practice.

1995 • 20 citations

Markers of prognosis in superficial bladder cancer.

1992 • 19 citations

Tumor Suppressor Gene Alterations in Bladder Carcinoma

1995 • 18 citations

Expression of ras p21 Oncogene Product on Human Bladder Tumors

1989 • 17 citations

Growth factors in bladder cancer

1995 • 15 citations

Superficial bladder cancer: the role of molecular markers in the treatment of high-risk superficial disease.

1997 • 11 citations

Cell surface differentiation antigens of normal urothelium and bladder tumors

1992 • 9 citations

Blood group antigen expression in bladder tumors: An immunohistochemical study of superficial bladder lesions

1994 • 7 citations