Release of soluble receptors for tumor necrosis factor (TNF) in relation to circulating TNF during experimental endotoxinemia.

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

Tumor Necrosis Factor (Cachectin) as an Essential Mediator in Murine Cerebral Malaria

1987 • 749 citations

Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.

1990 • 678 citations

Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors.

1990 • 557 citations

Peptide Regulatory Factors

1989 • 498 citations

Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents.

1991 • 452 citations

Shedding of tumor necrosis factor receptors by activated human neutrophils.

1990 • 443 citations

Two Different Cell Types have Different Major Receptors for Human Tumor Necrosis Factor (TNFα)

1989 • 368 citations

A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor.

1990 • 292 citations

Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences

1990 • 267 citations

A human inhibitor of tumor necrosis factor alpha.

1988 • 264 citations

Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients.

1991 • 234 citations

Characterization in vitro of a human tumor necrosis factor-binding protein. A soluble form of a tumor necrosis factor receptor.

1990 • 227 citations

Expression of the types A and B tumor necrosis factor (TNF) receptors is independently regulated, and both receptors mediate activation of the transcription factor NF-kappa B. TNF alpha is not needed for induction of a biological effect via TNF receptors.

1990 • 207 citations

Human neutrophil elastase releases a ligand-binding fragment from the 75-kDa tumor necrosis factor (TNF) receptor. Comparison with the proteolytic activity responsible for shedding of TNF receptors from stimulated neutrophils.

1991 • 193 citations

Infusion of tumor necrosis factor (TNF) causes an increase in circulating TNF-binding protein in humans

1990 • 176 citations

Recombinant 55-kDa tumor necrosis factor (TNF) receptor. Stoichiometry of binding to TNF alpha and TNF beta and inhibition of TNF activity.

1991 • 154 citations

Pretreatment with Ibuprofen Augments Circulating Tumor Necrosis Factor- , Interleukin-6, and Elastase during Acute Endotoxinemia

1991 • 137 citations

A tumor necrosis factor binding protein is present in human biological fluids

1988 • 122 citations

High levels of circulating soluble receptors for tumor necrosis factor in hairy cell leukemia and type B chronic lymphocytic leukemia.

1992 • 97 citations

Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients.

1991 • 86 citations

Cell surface tumor necrosis factor (TNF) accounts for monocyte- and lymphocyte-mediated killing of TNF-resistant target cells

1989 • 67 citations

Tumor necrosis factor receptors in lymphoid tissues and lymphomas. Source and site of action of tumor necrosis factor alpha.

1991 • 56 citations

Induction of plasma inhibitors of interleukin 1 and TNF-alpha activity by endotoxin administration to normal humans

1990 • 45 citations