Preventing drug access to targets: cell surface permeability barriers and active efflux in bacteria

Molecular basis of bacterial outer membrane permeability

1985 • 2,171 citations

THE ENVELOPE OF MYCOBACTERIA

1995 • 1,868 citations

Agents that increase the permeability of the outer membrane

1992 • 1,593 citations

Crystal structures explain functional properties of two E. coli porins

1992 • 1,493 citations

Multidrug efflux pumps of gram-negative bacteria

1996 • 1,071 citations

Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export

2000 • 1,052 citations

Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice

1999 • 730 citations

The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins.

1999 • 587 citations

Structure of the outer membrane protein A transmembrane domain

1998 • 471 citations

Multidrug resistance mechanisms: drug efflux across two membranes

2000 • 460 citations

Outer membrane barrier as a mechanism of antimicrobial resistance

1989 • 458 citations

The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol.

1996 • 457 citations

Porin channels in Escherichia coli: studies with liposomes reconstituted from purified proteins

1983 • 439 citations

Porin channels in Escherichia coli: studies with beta-lactams in intact cells

1983 • 370 citations

Inhibition of synthesis of arabinogalactan by ethambutol in Mycobacterium smegmatis

1989 • 350 citations

Bypassing the periplasm: Reconstitution of the AcrAB multidrug efflux pump of Escherichia coli

1999 • 348 citations

Outer membrane of gram-negative bacteria. XII. Molecular-sieving function of cell wall

1976 • 304 citations

Permeability barrier to hydrophilic solutes in Mycobacterium chelonei

1990 • 296 citations

Mycolic Acid Structure Determines the Fluidity of the Mycobacterial Cell Wall

1996 • 279 citations

Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples

1993 • 276 citations

Interplay between Efflux Pumps May Provide Either Additive or Multiplicative Effects on Drug Resistance

2000 • 260 citations

Multidrug Efflux Pump AcrAB of Salmonella typhimurium Excretes Only Those β-Lactam Antibiotics Containing Lipophilic Side Chains

1998 • 226 citations

AcrA is a highly asymmetric protein capable of spanning the periplasm 1 1Edited by I. B. Holland

1999 • 207 citations

Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis.

1996 • 197 citations

Identification and characterization of porins in Pseudomonas aeruginosa.

1991 • 188 citations

Molecular Cloning and Characterization of Tap, a Putative Multidrug Efflux Pump Present inMycobacterium fortuitumandMycobacterium tuberculosis

1998 • 184 citations

Mutants of Escherichia coli That Are Resistant to Certain Beta-Lactam Compounds Lack the ompF Porin

1981 • 178 citations

Physical organization of lipids in the cell wall of Mycobacterium chelonae

1993 • 175 citations

Sensitivity of Escherichia coli to various β‐lactams is determined by the interplay of outer membrane permeability and degradation by periplasmic β‐lactamases: a quantitative predictive treatment

1987 • 175 citations

Outer membranes of Gram‐negative bacteria are permeable to steroid probes

1992 • 173 citations

Antibiotic-supersusceptible mutants of Escherichia coli and Salmonella typhimurium

1993 • 173 citations

Porin alteration and active efflux: two in vivo drug resistance strategies used by Enterobacter aerogenes

1998 • 170 citations

Porin channels in intact cells of Escherichia coli are not affected by Donnan potentials across the outer membrane.

1988 • 160 citations

Secretion across the bacterial outer membrane

1992 • 160 citations

Refolded Outer Membrane Protein A of Escherichia coliForms Ion Channels with Two Conductance States in Planar Lipid Bilayers

2000 • 159 citations

Role of outer membrane barrier in efflux-mediated tetracycline resistance of Escherichia coli

1995 • 155 citations

Cloning of the mspA gene encoding a porin from Mycobacterium smegmatis

1999 • 152 citations

Gonococcal Resistance to β-Lactams and Tetracycline Involves Mutation in Loop 3 of the Porin Encoded at the penB Locus

1998 • 147 citations

Identification and Characterization of a New Porin Gene of Klebsiella pneumoniae : Its Role in β-Lactam Antibiotic Resistance

1999 • 132 citations

Prevalence of outer membrane porin alteration in beta-lactam-antibiotic-resistant Enterobacter aerogenes

1996 • 121 citations

OmpA protein of Escherichia coli outer membrane occurs in open and closed channel forms.

1994 • 120 citations

Secondary structure of the outer membrane proteins OmpA of Escherichia coli and OprF of Pseudomonas aeruginosa

1996 • 112 citations

Bacterial porins: structure and function

1993 • 110 citations

mmr , a Mycobacterium tuberculosis Gene Conferring Resistance to Small Cationic Dyes and Inhibitors

1998 • 106 citations

Expression of a Gene for a Porin-Like Protein of the OmpA Family fromMycobacterium tuberculosisH37Rv

1998 • 101 citations

The role of outer membrane and efflux pumps in the resistance of gram-negative bacteria. Can we improve drug access?

1998 • 91 citations

A mutant of Mycobacterium smegmatis defective in the biosynthesis of mycolic acids accumulates meromycolates

1999 • 89 citations

Outer Membrane Permeability of Pseudomonas aeruginosa

1986 • 83 citations

Cell Wall Structure of a Mutant of Mycobacterium smegmatis Defective in the Biosynthesis of Mycolic Acids

2000 • 64 citations

The Amino Terminus of Pseudomonas aeruginosa Outer Membrane Protein OprF Forms Channels in Lipid Bilayer Membranes: Correlation with a Three-Dimensional Model

2000 • 64 citations

Variation in the Composition and Pore Function of Major Outer Membrane Pore Protein P2 of Haemophilus influenzae from Cystic Fibrosis Patients

1999 • 20 citations