Role of outer membrane barrier in efflux-mediated tetracycline resistance of Escherichia coli

Experiments in molecular genetics

1972 • 28,260 citations

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

Antibodies, a laboratory manual

1989 • 12,929 citations

Substituent constants for correlation analysis in chemistry and biology

1979 • 2,909 citations

Molecular basis of bacterial outer membrane permeability

1985 • 2,171 citations

Mechanism of Assembly of the Outer Membrane of Salmonella typhimurium

1972 • 1,574 citations

Prevention of Drug Access to Bacterial Targets: Permeability Barriers and Active Efflux

1994 • 1,518 citations

The Movement of Molecules Across Cell Membranes

1967 • 1,196 citations

Cytoplasmic pH and free Mg2+ in lymphocytes.

1982 • 1,047 citations

Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon

1993 • 685 citations

ABC transporters: bacterial exporters

1993 • 607 citations

Selection for loss of tetracycline resistance by Escherichia coli

1981 • 585 citations

Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli.

1980 • 584 citations

Periplasmic space in Salmonella typhimurium and Escherichia coli.

1977 • 563 citations

Active efflux mechanisms for antimicrobial resistance

1992 • 500 citations

Molecular cloning and characterization of acrA and acrE genes of Escherichia coli

1993 • 459 citations

Tetracyclines, molecular and clinical aspects

1992 • 411 citations

Emr, an Escherichia coli locus for multidrug resistance.

1992 • 410 citations

Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacin

1994 • 395 citations

An efficient and reproducible procedure for the formation of spheroplasts from variously grown Escherichia coli

1976 • 394 citations

Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli

1993 • 393 citations

Outer membrane of Salmonella typhimurium

1976 • 379 citations

Porin channels in Escherichia coli: studies with beta-lactams in intact cells

1983 • 370 citations

Outer membrane of Salmonella typhimurium: chemical analysis and freeze-fracture studies with lipopolysaccharide mutants

1975 • 362 citations

Amplifiable resistance to tetracycline, chloramphenicol, and other antibiotics in Escherichia coli: involvement of a non-plasmid-determined efflux of tetracycline

1983 • 358 citations

Substrate specificity and transport properties of the glycerol facilitator of Escherichia coli

1980 • 321 citations

A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria

1994 • 320 citations

marA locus causes decreased expression of OmpF porin in multiple-antibiotic-resistant (Mar) mutants of Escherichia coli

1988 • 288 citations

Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples

1993 • 276 citations

Avidity of the Tetracyclines for the Cations of Metals

1956 • 253 citations

Pore-forming activity of OmpA protein of Escherichia coli.

1992 • 251 citations

Effect on solute size on diffusion rates through the transmembrane pores of the outer membrane of Escherichia coli.

1981 • 230 citations

Transport of divalent cations with tetracycline as mediated by the transposon Tn10-encoded tetracycline resistance protein.

1990 • 189 citations

Outer membranes of Gram‐negative bacteria are permeable to steroid probes

1992 • 173 citations

Porin channels in intact cells of Escherichia coli are not affected by Donnan potentials across the outer membrane.

1988 • 160 citations

Isolation of differentiated membrane domains from Escherichia coli and Salmonella typhimurium, including a fraction containing attachment sites between the inner and outer membranes and the murein skeleton of the cell envelope.

1986 • 149 citations

Pleiotropic transport mutants of Escherichia coli lack porin, a major outer membrane protein

1977 • 146 citations

Outer Membrane Proteins of Escherichia coli VII. Evidence That Bacteriophage-Directed Protein 2 Functions as a Pore

1978 • 129 citations

Topology of the transposon Tn10-encoded tetracycline resistance protein within the inner membrane of Escherichia coli

1989 • 111 citations

Lateral Mobility and Surface Density of Lipopolysaccharide in the Outer Membrane of Salmonella typhimurium

1974 • 111 citations

Stoichiometry of the proton-ATPase of growing and resting, aerobic Escherichia coli

1982 • 105 citations

Determination of a Protonation Scheme of Tetracycline Using Nuclear Magnetic Resonance.

1965 • 85 citations

Isolation and partial characterization of membrane vesicles carrying markers of the membrane adhesion sites

1982 • 79 citations

Two Transport Systems for Tetracycline in Sensitive Escherichia coli : Critical Role for an Initial Rapid Uptake System Insensitive to Energy Inhibitors

1978 • 61 citations

Stoichiometry of metal‐tetracycline/H⁺ antiport mediated by transposon Tn10‐encoded tetracycline resistance protein in Escherichia coli

1991 • 56 citations

Chemical-structural properties of tetracycline derivatives. 2. Coordination and conformational aspects of oxytetracycline metal ion complexation

1976 • 55 citations

Orientation of the carboxyl terminus of the transposon Tn10‐encoded tetracycline resistance protein in Escherichia coli

1990 • 52 citations

Transport of the lipophilic analog minocycline differs from that of tetracycline in susceptible and resistant Escherichia coli strains

1982 • 46 citations

Plasmid-Mediated Tetracycline Resistance in E. coli

1977 • 31 citations

Susceptible Escherichia coli cells can actively excrete tetracyclines

1983 • 29 citations

Unequal distribution of penicillin-binding proteins among inner membrane vesicles of Escherichia coli

1988 • 26 citations

Tetracycline uptake by susceptible Escherichia coli cells

1985 • 22 citations

Amplifiable Resistance toTetracycline, Chloramphenicol, and Other Antibiotics inEscherichia coli: Involvement ofaNon- Plasmid-Determined

1983 • 10 citations