Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis.

Basic local alignment search tool

1990 • 87,358 citations

Short protocols in molecular biology

1996 • 1,701 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

Prevention of Drug Access to Bacterial Targets: Permeability Barriers and Active Efflux

1994 • 1,518 citations

New use of BCG for recombinant vaccines

1991 • 1,463 citations

Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli

1991 • 784 citations

Fluoroquinolone Antimicrobial Agents

1991 • 562 citations

Mycobacterial cell wall: Structure and role in natural resistance to antibiotics

1994 • 547 citations

Active efflux mechanisms for antimicrobial resistance

1992 • 500 citations

Compilation and analysis of DNA sequences associated with apparent streptomycete promoters

1992 • 486 citations

Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations

1994 • 479 citations

Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones

1990 • 479 citations

[25] Genetic systems for mycobacteria

1991 • 437 citations

Emr, an Escherichia coli locus for multidrug resistance.

1992 • 410 citations

Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacin

1994 • 395 citations

Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli

1993 • 393 citations

Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones

1994 • 376 citations

Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system.

1991 • 367 citations

The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of streptomyces

1991 • 357 citations

The role of topoisomerase IV in partitioning bacterial replicons and the structure of catenated intermediates in DNA replication

1992 • 337 citations

Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins

1990 • 304 citations

Efflux pumps and drug resistance in Gram-negative bacteria

1994 • 284 citations

Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone‐resistant isolates

1994 • 271 citations

Discovery and development of new antibiotics: the problem of antibiotic resistance

1993 • 266 citations

Mechanisms of action of and resistance to ciprofloxacin.

1987 • 262 citations

Clinical Presentation and Outcome of Patients with HIV Infection and Tuberculosis Caused by Multiple-Drug-resistant Bacilli

1992 • 253 citations

Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome

1994 • 222 citations

Quinolone Antimicrobial Agents

1992 • 207 citations

Isolation and characterization of norfloxacin-resistant mutants of Escherichia coli K-12

1986 • 202 citations

Purification and characterization of DNA topoisomerase IV in Escherichia coli.

1992 • 194 citations

Superinfection immunity of mycobacteriophage L5: applications for genetic transformation of mycobacteria

1993 • 161 citations

Characterization of fluoroquinolone-resistant mutants of escherichia coli selected in vitro

1994 • 136 citations

Emergence of fluoroquinolone-resistant tuberculosis in New York City

1995 • 124 citations

Genetic relationship between soxRS and mar loci in promoting multiple antibiotic resistance in Escherichia coli

1994 • 110 citations

Nucleotide sequence analysis reveals similarities between proteins determining methylenomycin A resistance in Streptomyces and tetracycline resistance in eubacteria

1987 • 93 citations

Emergent resistance to ciprofloxacin amongst Pseudomonas aeruginosa and Staphylococcus aureus:clinical significance and therapeutic approaches

1990 • 83 citations

Nucleotide sequences and heterologous expression of tcmG and tcmP, biosynthetic genes for tetracenomycin C in Streptomyces glaucescens

1993 • 72 citations

Mechanism of quinolone mutagenicity in bacteria

1991 • 60 citations

The Saccharomyces cerevisiae SGE1 gene product: a novel drug-resistance protein within the major facilitator superfamily

1994 • 44 citations

Cloning of multidrug resistance gene pqrA from Proteus vulgaris

1995 • 32 citations

Antimycobacterial drugs.

1994 • 10 citations