Lamivudine plus interleukin-12 combination therapy in chronic hepatitis B: Antiviral and immunological activity

Histological grading and staging of chronic hepatitis

1995 • 4,862 citations

Interleukin-12 and the regulation of innate resistance and adaptive immunity

2003 • 3,689 citations

Hepatitis B Virus Infection — Natural History and Clinical Consequences

2004 • 2,271 citations

Immunology of hepatitis B virus and hepatitis C virus infection

2005 • 1,579 citations

Hepatitis B Virus Immunopathogenesis

1995 • 1,568 citations

Peginterferon Alfa-2a, Lamivudine, and the Combination for HBeAg-Positive Chronic Hepatitis B

2005 • 1,504 citations

THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

1998 • 1,253 citations

Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection

1999 • 1,208 citations

Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial

2005 • 1,154 citations

Intracellular Inactivation of the Hepatitis B Virus by Cytotoxic T Lymphocytes

1996 • 1,085 citations

CD8⁺T Cells Mediate Viral Clearance and Disease Pathogenesis during Acute Hepatitis B Virus Infection

2002 • 913 citations

The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis.

1995 • 483 citations

Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines

2003 • 461 citations

Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B.

1998 • 459 citations

Therapeutic dendritic-cell vaccine for chronic HIV-1 infection

2004 • 444 citations

Longitudinal Analysis of CD8⁺T Cells Specific for Structural and Nonstructural Hepatitis B Virus Proteins in Patients with Chronic Hepatitis B: Implications for Immunotherapy

2004 • 382 citations

Viruses, Immunity, and Cancer: Lessons from Hepatitis B

2000 • 294 citations

Interleukin-12 inhibits hepatitis B virus replication in transgenic mice

1997 • 237 citations

Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B

2003 • 236 citations

Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B.

1997 • 209 citations

Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B

1997 • 203 citations

Induction of interferon-γ production in Th1 CD4+ T cells: evidence for two distinct pathways for promoter activation

1999 • 202 citations

Dendritic Cells Efficiently Induce Protective Antiviral Immunity

1998 • 189 citations

Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam.

1995 • 179 citations

Resolution of chronic hepatitis B and anti-HBs seroconversion in humans by adoptive transfer of immunity to hepatitis B core antigen

2002 • 175 citations

Protective Immunity Using Recombinant Human IL-12 and Alum as Adjuvants in a Primate Model of Cutaneous Leishmaniasis

1999 • 158 citations

Sterile protection of monkeys against malaria after administration of interleukin-12

1997 • 144 citations

A phase I/II study of recombinant human interleukin-12 in patients with chronic hepatitis B

2000 • 113 citations

Virus-Specific Lymphokine Production Differs Quantitatively but Not Qualitatively in Acute and Chronic Hepatitis B Infection

1999 • 100 citations

Recombinant Duck Interferon Gamma Inhibits Duck Hepatitis B Virus Replication in Primary Hepatocytes

1999 • 88 citations

Cellular Immune Responses to the Hepatitis B Virus Polymerase

2004 • 88 citations

Impact of complete inhibition of viral replication on the cellular immune response in chronic hepatitis B virus infection

1996 • 85 citations

IL-12 Promotes Drug-Induced Clearance ofMycobacterium aviumInfection in Mice

1998 • 64 citations

Non-cytolytic inhibition of hepatitis B virus replication in human hepatocytes

2001 • 55 citations

HBV-specific lymphoproliferative and cytokine responses in patients with chronic hepatitis B

1998 • 51 citations

Reduced virus specific T helper cell induction by autologous dendritic cells in patients with chronic hepatitis B – restoration by exogenous interleukin-12

2002 • 48 citations

Therapy with a Combination of Low Doses of Interleukin 12 and Chloroquine Completely Cures Blood-Stage Malaria, Prevents Severe Anemia, and Induces Immunity to Reinfection

1999 • 48 citations

Woodchuck Gamma Interferon Upregulates Major Histocompatibility Complex Class I Transcription but Is Unable To Deplete Woodchuck Hepatitis Virus Replication Intermediates and RNAs in Persistently Infected Woodchuck Primary Hepatocytes

2002 • 41 citations

A multicenter study of recombinant human interleukin 12 for the treatment of chronic hepatitis C virus infection in patients nonresponsive to previous therapy

2003 • 40 citations

Priming for high interferon-gamma production induced by interleukin-12 in both CD4+ and CD8+ T cell clones from HIV-infected patients.

1995 • 39 citations

Double-blind, randomized controlled trial of interleukin-2 treatment of chronic hepatitis B

1998 • 37 citations

A Phase I, placebo-controlled trial of multi-dose recombinant human interleukin-12 in patients with HIV infection

2002 • 36 citations

A randomised controlled trial of recombinant interferon‐γ in chinese patients with chronic hepatitis B virus infection

1991 • 32 citations

Helper-Dependent Adenoviral Vector-Mediated Delivery of Woodchuck-Specific Genes for Alpha Interferon (IFN-α) and IFN-γ: IFN-α but Not IFN-γ Reduces Woodchuck Hepatitis Virus Replication in Chronic Infection In Vivo

2004 • 32 citations

Studies of interleukin‐12 in chronic hepatitis B virus infection

1997 • 18 citations

A pilot trial of recombinant interleukin-12 in patients with chronic hepatitis C who previously failed treatment with interferon-α

2001 • 11 citations

A pilot trial of recombinant interleukin-12 in patients with chronic hepatitis C who previously failed treatment with interferon-α

2001 • 4 citations