Sterile protection of monkeys against malaria after administration of interleukin-12

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

1994 • 1,066 citations

Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity.

1995 • 407 citations

IL-12-induced protection against blood-stage Plasmodium chabaudi AS requires IFN-gamma and TNF-alpha and occurs via a nitric oxide-dependent mechanism.

1995 • 314 citations

Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection.

1994 • 290 citations

Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology.

1994 • 274 citations

Interleukin 12 induction of interferon gamma-dependent protection against malaria.

1994 • 185 citations

IFN-gamma inhibits development of Plasmodium berghei exoerythrocytic stages in hepatocytes by an L-arginine-dependent effector mechanism.

1991 • 169 citations

Comparative sequence analysis of cytokine genes from human and nonhuman primates.

1995 • 152 citations

IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia.

1995 • 121 citations

Nitric oxide-mediated antiplasmodial activity in human and murine hepatocytes induced by gamma interferon and the parasite itself: enhancement by exogenous tetrahydrobiopterin

1994 • 92 citations

Recombinant human gamma interferon inhibits simian malaria

1986 • 83 citations

Biologic effects of recombinant human interleukin-12 in squirrel monkeys (Sciureus saimiri).

1994 • 82 citations

In vitro maturation of human neonatal CD4 T lymphocytes. I. Induction of IL-4-producing cells after long-term culture in the presence of IL-4 plus either IL-2 or IL-12.

1994 • 75 citations

Qualitative and quantitative studies of cytokines synthesized and secreted by non-human primate peripheral blood mononuclear cells

1993 • 68 citations

Interleukin-12: Potential Clinical Applications in the Treatment and Prevention of Infectious Diseases

1996 • 31 citations

II. Responses of Sporozoite-Induced and Trophozoite-Induced Infections to Standard Antimalarial Drugs

1982 • 27 citations

Plasmodium Cynomolgi Infections in the Rhesus Monkey *

1982 • 26 citations

Susceptibility of Plasmodium falciparum to a peroxidase-mediated oxygen-dependent microbicidal system

1988 • 20 citations

Pharmacokinetics and pharmacodynamics of recombinant human interleukin-12 in male rhesus monkeys.

1995 • 20 citations

The role of cytokines in malaria infection.

1990 • 13 citations

Human Interferon-γ Protects Rhesus Monkeys Against Sporozoite-InducedPlasmodium cynomolgiMalaria Infection

1988 • 11 citations