A Phase I, placebo-controlled trial of multi-dose recombinant human interleukin-12 in patients with HIV infection

Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma.

1984 • 1,083 citations

Phase I evaluation of intravenous recombinant human interleukin 12 in patients with advanced malignancies.

1997 • 556 citations

Restoration of HIV-Specific Cell-Mediated Immune Responses by Interleukin-12 in Vitro

1993 • 397 citations

Interferon-α/β inhibition of interleukin 12 and interferon-γ productionin vitroand endogenously during viral infection

1997 • 303 citations

Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a paradox

2000 • 293 citations

Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome

1995 • 249 citations

Effects of IL-12 on the response and susceptibility to experimental viral infections.

1994 • 233 citations

Phase I trial of subcutaneous recombinant human interleukin-12 in patients with advanced renal cell carcinoma.

1998 • 219 citations

Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids.

1995 • 215 citations

Interleukin-12 in infectious diseases

1997 • 214 citations

Immunological effects of interleukin 12 administered by bolus intravenous injection to patients with cancer.

1999 • 173 citations

Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements

1998 • 168 citations

Pilot study of subcutaneous recombinant human interleukin 12 in metastatic melanoma.

1998 • 160 citations

A phase I/II study of recombinant human interleukin-12 in patients with chronic hepatitis B

2000 • 113 citations

Phase I study of subcutaneously administered recombinant human interleukin 12 in patients with advanced renal cell cancer.

1999 • 108 citations

In vivo treatment with interleukin 12 protects mice from immune abnormalities observed during murine acquired immunodeficiency syndrome (MAIDS).

1994 • 106 citations

In Vitro Restoration of T Cell Immune Function in Human Immunodeficiency Virus-Positive Persons: Effects of Interleukin (IL)-12 and Anti-IL-IO

1996 • 88 citations

Human Immunodeficiency Virus Infection in the US Air Force: Seroconversions, Clinical Staging, and Assessment of a T Helper Cell Functional Assay to Predict Change in CD4+ T Cell Counts

1991 • 84 citations

Pentoxifylline Therapy in Human Immunodeficiency Virus--Seropositive Persons with Tuberculosis: A Randomized, Controlled Trial

1996 • 73 citations

Three-color supplement to the NIAID DAIDS guideline for flow cytometric immunophenotyping

1996 • 68 citations

Effects of the Th1 and Th2 stimulatory cytokines interleukin-12 and interleukin-4 on human immunodeficiency virus replication

1995 • 65 citations

Interleukin-12 protects thermally injured mice from herpes simplex virus type 1 infection

1996 • 63 citations

The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon

1995 • 59 citations

A phase I/II study of recombinant human interleukin-12 in patients with chronic hepatitis C

1999 • 56 citations

Phase 1 Trial of a Single Dose of Recombinant Human Interleukin–12 in Human Immunodeficiency Virus–Infected Patients with 100–500 CD4 Cells/μL

2000 • 44 citations

Induction of HIV-1 replication by type 1-like cytokines, interleukin (IL)-12 and IL-15: effect on viral transcriptional activation, cellular proliferation, and endogenous cytokine production.

1998 • 41 citations

Interleukin-12 enhances antigen-specific proliferation of peripheral blood mononuclear cells from HIV-positive and negative donors in response to Mycobacterium avium

1994 • 34 citations

Protection of mice from Mycobacterium avium infection by recombinant interleukin-12

1995 • 34 citations

In Vitro Effect of Interleukin-12 on Antigen-Specific Lymphocyte Proliferative Responses from Persons Infected with Human Immunodeficiency Virus Type 1

1996 • 26 citations

Interleukin-12 Administered In Vivo Decreases Human NK Cell Cytotoxicity and Antibody-Dependent Cellular Cytotoxicity to Human Immunodeficiency Virus--Infected Cells

1996 • 25 citations

Selective Increases in HIV-Specific Neutralizing Antibody and Partial Reconstitution of Cellular Immune Responses during Prolonged, Successful Drug Therapy of HIV Infection

2001 • 24 citations

Patterns of Interferon-γ Production by Peripheral Blood Mononuclear Cells from Patients with Human Immunodeficiency Virus Infection

1990 • 15 citations

Characterization of HIV-Specific Proliferative T Cell Responses in HIV-Infected Persons

2001 • 6 citations