Cellular Immune Responses to the Hepatitis B Virus Polymerase

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

A One-Year Trial of Lamivudine for Chronic Hepatitis B

1998 • 1,779 citations

Hepatitis B Virus Immunopathogenesis

1995 • 1,568 citations

Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection

1999 • 1,208 citations

Noncytolytic Control of Viral Infections by the Innate and Adaptive ImmuneResponse

2001 • 1,000 citations

The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.

1994 • 838 citations

Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C

2000 • 747 citations

Several Common HLA-DR Types Share Largely Overlapping Peptide Binding Repertoires

1998 • 647 citations

Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: Results after 3 years of therapy

2001 • 641 citations

Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen

1999 • 586 citations

Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides

1994 • 516 citations

Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection.

1990 • 503 citations

The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis.

1995 • 483 citations

Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B.

1998 • 459 citations

Hepatitis-B-virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation

1997 • 456 citations

Immunobiology and Pathogenesis of Hepatocellular Injury in Hepatitis B Virus Transgenic Mice

1990 • 363 citations

Direct ex vivo analysis of hepatitis B virus-specific CD8+ T cells associated with the control of infection

1999 • 358 citations

Long-Term Therapy of Chronic Hepatitis B With Lamivudine

2000 • 355 citations

Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: New perspectives for immune therapy

2001 • 335 citations

HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection.

1993 • 333 citations

Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans.

1995 • 332 citations

Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection.

1996 • 299 citations

Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion.

1992 • 294 citations

Long-lasting memory T cell responses following self-limited acute hepatitis B.

1996 • 290 citations

On the interaction of promiscuous antigenic peptides with different DR alleles. Identification of common structural motifs.

1991 • 242 citations

Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules

1994 • 234 citations

HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis.

1993 • 224 citations

Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line.

1987 • 222 citations

Cd40-Independent Pathways of T Cell Help for Priming of Cd8+ Cytotoxic T Lymphocytes

2000 • 201 citations

Helper-cytotoxic T lymphocyte (CTL) determinant linkage required for priming of anti-HIV CD8+ CTL in vivo with peptide vaccine constructs.

1994 • 181 citations

A pilot study of the CY-1899 T-cell vaccine in subjects chronically infected with hepatitis B virus

1999 • 168 citations

Human histocompatibility leukocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte responses in patients with acute hepatitis.

1997 • 163 citations

Interleukin-2 and alpha/beta interferon down-regulate hepatitis B virus gene expression in vivo by tumor necrosis factor-dependent and -independent pathways

1994 • 140 citations

The hepatitis B virus-specific CTL responses induced in humans by lipopeptide vaccination are comparable to those elicited by acute viral infection.

1997 • 137 citations

Selective expansion of cytotoxic T lymphocytes with a CD4+CD56+ surface phenotype and a T helper type 1 profile of cytokine secretion in the liver of patients chronically infected with Hepatitis B virus.

1994 • 136 citations

Altered Helper T Lymphocyte Function Associated with Chronic Hepatitis B Virus Infection and its Role in Response to Therapeutic Vaccination in Humans

1999 • 128 citations

Immunogenicity and Tolerogenicity of Hepatitis B Virus Structural and Nonstructural Proteins: Implications for Immunotherapy of Persistent Viral Infections

2002 • 127 citations

Two Sensitive PCR-Based Methods for Detection of Hepatitis B Virus Variants Associated with Reduced Susceptibility to Lamivudine

1999 • 123 citations

Structural analysis of peptides capable of binding to more than one Ia antigen.

1989 • 112 citations

Identification and Antigenicity of Broadly Cross-Reactive and Conserved Human Immunodeficiency Virus Type 1-Derived Helper T-Lymphocyte Epitopes

2001 • 108 citations

Recognition of hepatitis B surface antigen by human T lymphocytes. Proliferative and cytotoxic responses to a major antigenic determinant defined by synthetic peptides.

1988 • 107 citations

Cutting Edge: Inhibition of Hepatitis B Virus Replication by Activated NK T Cells Does Not Require Inflammatory Cell Recruitment to the Liver

2001 • 103 citations

Virus-Specific Lymphokine Production Differs Quantitatively but Not Qualitatively in Acute and Chronic Hepatitis B Infection

1999 • 100 citations

Impact of complete inhibition of viral replication on the cellular immune response in chronic hepatitis B virus infection

1996 • 85 citations

Synthesis and Characterization of Branched DNA (bDNA) for the Direct and Quantitative Detection of CMV, HBV, HCV, and HIV

1993 • 78 citations

The DY sub-region of the sheep MHC contains an A/B gene pair

1994 • 65 citations

Molecular features of the hepatitis B virus nucleocapsid T-cell epitope 18-27: Interaction with HLA and T-cell receptor

1997 • 58 citations

Frequencies of interferon-γ and interleukin-10 secreting cells in peripheral blood mononuclear cells and liver infiltrating lymphocytes in chronic hepatitis B virus infection

2003 • 46 citations

Strong similarities in antigen fine specificity among DRB1* 1302-restricted tetanus toxin tt830-843-specific TCRs in spite of highly heterogeneous CDR3.

1995 • 35 citations

HBcAg-specific cytokine production by CD4 T lymphocytes of children with acute and chronic hepatitis B

2003 • 25 citations

Tracking the Source of the Hepatitis B Virus–Specific CD8 T Cells during Lamivudine Treatment

2003 • 21 citations

Steatosis Hepatis in Celiac Disease

1999 • 18 citations