Therapeutic dendritic-cell vaccine for chronic HIV-1 infection

Viral Load and Heterosexual Transmission of Human Immunodeficiency Virus Type 1

2000 • 2,986 citations

Vigorous HIV-1-Specific CD4 ⁺ T Cell Responses Associated with Control of Viremia

1997 • 1,868 citations

Abnormalities of B-Cell Activation and Immunoregulation in Patients with the Acquired Immunodeficiency Syndrome

1983 • 1,625 citations

HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression

1999 • 766 citations

Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection

1995 • 702 citations

Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know

2004 • 447 citations

HIV-1 Viremia Prevents the Establishment of Interleukin 2–producing HIV-specific Memory CD4+ T Cells Endowed with Proliferative Capacity

2003 • 443 citations

Loss of blood CD11c+ myeloid and CD11c−plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load

2001 • 393 citations

Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8⁺and CD4⁺T lymphocytes

2000 • 392 citations

Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1–infected subjects with progressive disease: changes after antiretroviral therapy

2003 • 380 citations

Reduced blood CD123+ (lymphoid) and CD11c+ (myeloid) dendritic cell numbers in primary HIV-1 infection

2001 • 354 citations

Levels of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Effector and Memory Responses Decline after Suppression of Viremia with Highly Active Antiretroviral Therapy

1999 • 310 citations

Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates

1995 • 293 citations

Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers

2003 • 279 citations

Frequency of Class I HLA-Restricted Anti-HIV CD8+ T Cells in Individuals Receiving Highly Active Antiretroviral Therapy (HAART)

1999 • 274 citations

Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers

2003 • 252 citations

Therapeutic dendritic-cell vaccine for simian AIDS

2002 • 239 citations

Presence of HIV-1 Gag-Specific IFN-γ+IL-2+ and CD28+IL-2+ CD4 T Cell Responses Is Associated with Nonprogression in HIV-1 Infection

2002 • 237 citations

Detection of functionally altered hepatitis C virus-specific CD4+ T cells in acute and chronic hepatitis C

2003 • 221 citations

A Significant Number of Human Immunodeficiency Virus Epitope-Specific Cytotoxic T Lymphocytes Detected by Tetramer Binding Do Not Produce Gamma Interferon

2000 • 201 citations

DC-SIGN promotes exogenous MHC-I–restricted HIV-1 antigen presentation

2003 • 190 citations

Persistent numbers of tetramer+ CD8+ T cells, but loss of interferon-γ+ HIV-specific T cells during progression to AIDS

2002 • 186 citations

Depletion in blood CD11c-positive dendritic cells from HIV-infected patients

1999 • 181 citations

Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection

2003 • 180 citations

Antigen-presenting cell types

1993 • 179 citations

Effect of Combination Antiretroviral Therapy on T‐Cell Immunity in Acute Human Immunodeficiency Virus Type 1 Infection

2000 • 159 citations

Neutralization sensitivity of cell culture-passaged simian immunodeficiency virus

1997 • 157 citations

MHC-I–restricted presentation of HIV-1 virion antigens without viral replication

2001 • 153 citations

CD40 and Dendritic Cell Function

2003 • 146 citations

Adaptation to persistent growth in the H9 cell line renders a primary isolate of human immunodeficiency virus type 1 sensitive to neutralization by vaccine sera

1995 • 143 citations

The Influence of HIV Infection on Antibody Responses to a Two-Dose Regimen of Influenza Vaccine

1989 • 141 citations

Infectious and Whole Inactivated Simian Immunodeficiency Viruses Interact Similarly with Primate Dendritic Cells (DCs): Differential Intracellular Fate of Virions in Mature and Immature DCs

2002 • 139 citations

Potent Immune Response against HIV-1 and Protection from Virus Challenge in hu-PBL-SCID Mice Immunized with Inactivated Virus-pulsed Dendritic Cells Generated in the Presence of IFN-α

2003 • 126 citations

HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication

2004 • 111 citations

A Pilot Clinical Trial of HIV Antigen-Pulsed Allogeneic and Autologous Dendritic Cell Therapy in HIV-Infected Patients

1998 • 109 citations

Longitudinal study of leukocyte functions in homosexual men seroconverted for HIV: rapid and persistent loss of B cell function after HIV infection

1989 • 109 citations

Normal Immune Function of Monocyte-Derived Dendritic Cells from HIV-Infected Individuals: Implications for Immunotherapy

1999 • 81 citations

CpG-C Immunostimulatory Oligodeoxyribonucleotide Activation of Plasmacytoid Dendritic Cells in Rhesus Macaques to Augment the Activation of IFN-γ-Secreting Simian Immunodeficiency Virus-Specific T Cells

2004 • 68 citations

Dendritic cells generated from blood monocytes of HIV-1 patients are not infected and act as competent antigen presenting cells eliciting potent T-cell responses

1999 • 65 citations

Induction of Protective Immune Responses against R5 Human Immunodeficiency Virus Type 1 (HIV-1) Infection in hu-PBL-SCID Mice by Intrasplenic Immunization with HIV-1-Pulsed Dendritic Cells: Possible Involvement of a Novel Factor of Human CD4⁺T-Cell Origin

2003 • 59 citations

In Vitro Human Immunodeficiency Virus Eradication by Autologous CD8⁺T Cells Expanded with Inactivated-Virus-Pulsed Dendritic Cells

2001 • 43 citations

Short Communication Low CD83, but Normal MHC Class II and Costimulatory Molecule Expression, on Spleen Dendritic Cells from HIV⁺Patients

1998 • 36 citations

Antiviral treatment of recurrent hepatitis C virus (HCV) infection after liver transplantation: association of a strong, multispecific, and long-lasting CD4+ T cell response with HCV-elimination

2003 • 33 citations

HBcAg-specific cytokine production by CD4 T lymphocytes of children with acute and chronic hepatitis B

2003 • 25 citations

Enhanced Dendritic Cell-Driven Proliferation and Anti-HIV Activity of CD8+ T Cells by a New Phenothiazine Derivative, Aminoperazine

2001 • 16 citations

Equivalent amplification of intrinsically variable nucleic acid sequences by multiple-primer-induced overlapping amplification assay: Applications for universal detection and quantitation

1999 • 14 citations