CYP2D6: novel genomic structures and alleles

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity

2004 • 1,075 citations

Genome architecture, rearrangements and genomic disorders

2002 • 906 citations

Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response

2004 • 708 citations

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

1993 • 652 citations

The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen

2006 • 554 citations

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

1994 • 429 citations

CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure

2007 • 388 citations

Gene amplification, drug resistance, and cancer.

1984 • 284 citations

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism.

1991 • 273 citations

Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6

2001 • 269 citations

Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology

1995 • 243 citations

Double minute chromosomes can be produced from precursors derived from a chromosomal deletion.

1988 • 236 citations

Ultrarapid metabolizers of debrisoquine: Characterization and PCR‐based detection of alleles with duplication of the CYP2D6 gene

1996 • 198 citations

CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-rime PCR

2003 • 154 citations

Cytochrome P4502D6 (CYP2D6) Gene Locus Heterogeneity: Characterization of Gene Duplication Events

2007 • 147 citations

Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genes

1999 • 146 citations

Functional Characterization of 17CYP2D6Allelic Variants (CYP2D6.2, 10, 14A–B, 18, 27, 36, 39, 47–51, 53–55, and 57)

2008 • 140 citations

Characterization of an Episome Produced in Hamster Cells that Amplify a Transfected CAD Gene at High Frequency: Functional Evidence for a Mammalian Replication Origin

1987 • 137 citations

Extrachromosomal Circular DNA of Tandemly Repeated Genomic Sequences in Drosophila

2003 • 137 citations

UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells.

1984 • 130 citations

DNA amplification in drug resistant cells and in tumours.

1986 • 115 citations

Molecular biology of double‐minute chromosomes

1993 • 104 citations

Small circular DNA in Drosophila melanogaster

1976 • 99 citations

CYP2D6*36GENE ARRANGEMENTS WITHIN THECYP2D6LOCUS: ASSOCIATION OFCYP2D6*36WITH POOR METABOLIZER STATUS

2006 • 87 citations

Double minutes arise from circular extrachromosomal DNA intermediates which integrate into chromosomal sites in human HL-60 leukemia cells.

1990 • 84 citations

Induction of Circles of Heterogeneous Sizes in Carcinogen-Treated Cells: Two-Dimensional Gel Analysis of Circular DNA Molecules

1996 • 82 citations

Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional evidence for a mammalian replication origin.

1987 • 80 citations

Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of the human cytochrome P450 CYP2D6 gene

1995 • 73 citations

Characterization and PCR-based detection of two different hybrid CYP2D7P/CYP2D6 alleles associated with the poor metabolizer phenotype??

1996 • 62 citations

Localization of a bidirectional DNA replication origin in the native locus and in episomally amplified murine adenosine deaminase loci.

1993 • 58 citations

Evidence for rolling circle replication of tandem genes in Drosophila

2005 • 53 citations

Formation of extrachromosomal circles from telomeric DNA in Xenopus laevis

2002 • 52 citations

Formation of extrachromosomal circular DNA in HeLa cells by nonhomologous recombination

1994 • 51 citations

A novel cell-free system reveals a mechanism of circular DNA formation from tandem repeats

2001 • 44 citations

The impact of CYP allelic variation on antidepressant metabolism: a review

2007 • 40 citations

An unequal cross‐over event within the CYP2D gene cluster generates a chimeric CYP2D7/CYP2D6 gene which is associated with the poor metabolizer phenotype.

1995 • 33 citations

New allelic arrangement CYP2D6*36??2 found in a Japanese poor metabolizer of debrisoquine

2002 • 25 citations

Novel Structure of the CYP2D6 Gene that Confuses Genotyping for the CYP2D6*5 Allele

2005 • 16 citations

CpG island mapping of a mouse double-minute chromosome.

1993 • 8 citations