Gene amplification, drug resistance, and cancer.

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

1982 • 1,746 citations

Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

1981 • 1,611 citations

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

1978 • 972 citations

Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.

1983 • 764 citations

TANDEM GENETIC DUPLICATIONS IN PHAGE AND BACTERIA

1977 • 479 citations

THE EFFECTS OF UNEQUAL CROSSING OVER AT THE BAR LOCUS IN DROSOPHILA

1925 • 432 citations

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

1979 • 376 citations

Analysis of avian leukosis virus DNA and RNA in bursal tumors: Viral gene expression is not required for maintenance of the tumor state

1981 • 346 citations

Amplification of genes for chorion proteins during oogenesis in Drosophila melanogaster

1980 • 301 citations

[Specific gene amplification in oocytes].

1969 • 300 citations

MINUTE CHROMATIN BODIES IN MALIGNANT TUMOURS OF CHILDHOOD

1965 • 286 citations

Chromosomes and cancer

2009 • 266 citations

Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

1982 • 248 citations

Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells

1976 • 237 citations

Properties of an altered dihydrofolate reductase encoded by amplified genes in cultured mouse fibroblasts.

1981 • 212 citations

DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression.

1982 • 201 citations

Double Minute Chromosomes and the Homogeneously Staining Regions in Chromosomes of a Human Neuroblastoma Cell Line

1977 • 195 citations

Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo.

1981 • 191 citations

Enhancement of Methotrexate Resistance and Dihydrofolate Reductase Gene Amplification by Treatment of Mouse 3T6 Cells with Hydroxyurea

1983 • 191 citations

Gene amplification in a single cell cycle in Chinese hamster ovary cells.

1984 • 190 citations

Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.

1979 • 185 citations

Recombination between short DNA homologies causes tandem duplication

1981 • 184 citations

Unstable Methotrexate Resistance in Human Small-Cell Carcinoma Associated with Double Minute Chromosomes

1983 • 178 citations

Pharmacokinetics of methotrexate

1974 • 158 citations

Resistance to methotrexate due to gene amplification in a patient with acute leukemia.

1984 • 145 citations

Gene amplification in a leukemic patient treated with methotrexate.

1984 • 139 citations

Cloned cDNA sequences of the hypoxanthine/guanine phosphoribosyltransferase gene from a mouse neuroblastoma cell line found to have amplified genomic sequences.

1982 • 136 citations

Two distinct candidate transforming genes of lymphoid leukosis virus-induced neoplasms

1981 • 135 citations

UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells.

1984 • 130 citations

Correlation of double-minute chromosomes with unstable multidrug cross-resistance in uptake mutants of neuroblastoma cells.

1981 • 114 citations

The remarkable instability of replication loops provides a general method for the isolation of origins of DNA replication

1981 • 92 citations

Gene-amplification model of carcinogenesis.

1981 • 86 citations

Double Minutes in Human Carcinoma Cell Lines, With Special Reference to Breast Tumors<xref ref-type="fn" rid="fn2">2</xref>

1979 • 78 citations

Selective overproduction of adenosine deaminase in cultured mouse cells.

1983 • 75 citations

Replication of the Bacterial Chromosome: Location of New Initiation Sites After Irradiation

1969 • 75 citations

Gene amplification in methotrexate-resistant mouse cells

1981 • 66 citations

The Nucleolus and the Rolling Circle

1974 • 64 citations

Amplification and rearrangement of onc genes in mammalian species

1982 • 56 citations

Chromomycin A3 as a fluorescent probe for flow cytometry of human gynecologic samples.

1977 • 51 citations

Evidence for double replication of chromosomal DNA segments as a general consequence of DNA replication inhibition.

1981 • 45 citations

Overproduction of dihydrofolate reductase and gene amplification in methotrexate-resistant Chinese hamster ovary cells.

1982 • 41 citations

Double minutes in human large bowel cancer

1980 • 26 citations

A heterochromatic homogeneously staining region (HSR) in the karyotype of a human breast carcinoma cell line

1980 • 22 citations

Flow cytometric analysis of DNA content for ploidy determination in human solid tumors.

1979 • 20 citations

Metabolism of methotrexate in man after high and conventional doses.

1980 • 18 citations

Limitations of DNA histogram analysis by flow cytometry as a method of predicting chemosensitivity in a rat renal cancer model.

1983 • 14 citations