Regulation of the estrogen-responsive pS2 gene in MCF-7 human breast cancer cells

Current protocols in molecular biology

1988 • 7,584 citations

Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

1998 • 5,487 citations

Cloning of a novel receptor expressed in rat prostate and ovary.

1996 • 4,782 citations

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β

1997 • 4,422 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

ERβ: Identification and characterization of a novel human estrogen receptor

1996 • 2,262 citations

Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy

1992 • 2,084 citations

Steroid hormone receptors: Many Actors in search of a plot

1995 • 1,854 citations

Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase

1997 • 1,251 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

1997 • 1,218 citations

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors and

1997 • 1,148 citations

A potent specific pure antiestrogen with clinical potential.

1991 • 1,111 citations

Crystal structure of a yeast TBP/TATA-box complex

1993 • 1,082 citations

Systemic Treatment of Early Breast Cancer by Hormonal, Cytotoxic, or Immune Therapy:133 Randomised Trials involoving 31 000 Recurrences and 24 000 Deaths Among 75 000 Women (Summary)

1993 • 967 citations

Nuclear receptor coactivators and corepressors.

1996 • 917 citations

What's Up and Down with Histone Deacetylation and Transcription?

1997 • 831 citations

Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line

1982 • 727 citations

Nuclear receptor coactivators and corepressors

1996 • 414 citations

Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor

1994 • 402 citations

Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7.

1984 • 379 citations

Comparison of the Effects of a Pure Steroidal antiestrogen With Those of Tamoxifen in a Model of Human Breast Cancer

1995 • 363 citations

Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).

1992 • 354 citations

Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer

1995 • 351 citations

p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation

1998 • 337 citations

Estrogen-responsive element of the human pS2 gene is an imperfectly palindromic sequence.

1989 • 330 citations

In vivo protein–DNA interactions in a glucocorticoid response element require the presence of the hormone

1986 • 328 citations

Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7

1984 • 304 citations

Investigation of a new pure antiestrogen (ICI 182780) in women with primary breast cancer.

1994 • 289 citations

Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogene ERBB2.

1987 • 279 citations

In vivo footprinting of rat TAT gene: Dynamic interplay between the glucocorticoid receptor and a liver-specific factor

1991 • 270 citations

The 5′ flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein.

1989 • 260 citations

Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain.

1993 • 249 citations

Effects of estrogens and antiestrogens on estrogen receptor dynamics and the induction of progesterone receptor in MCF-7 human breast cancer cells.

1982 • 212 citations

Glucocorticoids are required for establishment and maintenance of an alteration in chromatin structure: induction leads to a reversible disruption of nucleosomes over an enhancer.

1991 • 206 citations

MCF7/LCC2: a 4-hydroxytamoxifen resistant human breast cancer variant that retains sensitivity to the steroidal antiestrogen ICI 182,780.

1993 • 195 citations

Multihormonal Regulation of the Progesterone Receptor in MCF-7 Human Breast Cancer Cells: Interrelationships among Insulin/Insulin-Like Growth Factor-I, Serum, and Estrogen*

1990 • 187 citations

Progression of human breast cancer cells from hormone-dependent to hormone-independent growth both in vitro and in vivo.

1989 • 182 citations

Prediction of relapse and survival in breast cancer patients by pS2 protein status.

1990 • 179 citations

Mobility Shift <scp>DNA</scp>‐Binding Assay Using Gel Electrophoresis

1996 • 167 citations

Transcriptional Activators Differ in Their Responses to Overexpression of TATA-Box-Binding Protein

1995 • 163 citations

DNA recognition by DNase I

1994 • 139 citations

Characterization of the Estrogen-Induced pS2 Protein Secreted by the Human Breast Cancer Cell Line MCF-7*

1987 • 125 citations

pS2 expression and response to hormonal therapy in patients with advanced breast cancer.

1991 • 123 citations

Progesterone Receptor Regulation in T47D Human Breast Cancer Cells: Analysis by Density Labeling of Progesterone Receptor Synthesis and Degradation and Their Modulation by Progestin*

1988 • 114 citations

Structure of the human oestrogen-responsive gene pS2

1987 • 113 citations

Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain

1993 • 105 citations

Mechanisms of antihormone action

1992 • 104 citations

Evaluation of tamoxifen dose in advanced breast cancer: a progress report.

1976 • 97 citations

Tissue-specific and steroid-dependent interaction of transcription factors with the oestrogen-inducible apoVLDL II promoter in vivo.

1988 • 86 citations

Human estrogen receptor bound to an estrogen response element bends DNA.

1993 • 85 citations

Mechanism of estrogen receptor-dependent transcription in a cell-free system.

1990 • 84 citations

Different TBP-associated factors are required for mediating the stimulation of transcriptionin vitroby the acidic transactivator GAL-VP16 and the two nonacidic activation functions of the estrogen receptor

1993 • 81 citations

Ligand-dependent occupancy of the retinoic acid receptor beta 2 promoter in vivo.

1994 • 65 citations

Ligation‐Mediated <scp>PCR</scp> for Genomic Sequencing and Footprinting

2001 • 65 citations

Estrogen receptor affinity and location of consensus and imperfect estrogen response elements influence transcription activation of simplified promoters.

1996 • 64 citations

A ligand-induced conformational change in the estrogen receptor is localized in the steroid binding domain

1992 • 62 citations

Conformational transitions of the estrogen receptor monomer. Effects of estrogens, antiestrogen, and temperature.

1986 • 57 citations

Nucleosome Positioning and Transcription-associated Chromatin Alterations on the Human Estrogen-responsive pS2 Promoter

1997 • 54 citations

Estrogen receptor-induced DNA bending: orientation of the bend and replacement of an estrogen response element with an intrinsic DNA bending sequence.

1995 • 50 citations

Dissection of progesterone receptor-mediated chromatin remodeling and transcriptional activation in vivo.

1995 • 45 citations

Regulation of pS2 Gene Expression by Affinity Labeling and Reversibly Binding Estrogens and Antiestrogens: Comparison of Effects on the Native Gene and on pS2-Chloramphenicol Acetyltransferase Fusion Genes Transfected into MCF-7 Human Breast Cancer Cells

1988 • 44 citations

Estrogen receptor-induced bending of the Xenopus vitellogenin A2 gene hormone response element

1992 • 44 citations

In vivo footprinting of an androgen-dependent enhancer reveals an accessory element integral to hormonal response.

1995 • 44 citations

Purified estrogen receptor DNA binding domain expressed in Escherichia coli activates transcription of an estrogen-responsive promoter in cultured cells.

1991 • 41 citations

Estrogen-Dependent Transcriptional Activation and Vitellogenin Gene Memory

1997 • 33 citations

DNA bending is induced by binding of the glucocorticoid receptor DNA binding domain and progesterone receptors to their response element

1997 • 31 citations

Human estrogen receptor bound to an estrogen response element bends DNA

1993 • 28 citations

Estrogen receptor affinity and location of consensus and imperfect estrogen response elements influence transcription activation of simplified promoters

1996 • 27 citations

Are breast tumours resistant to tamoxifen also resistant to pure antioestrogens?

1993 • 26 citations

An improved protocol for genomic sequencing and footprinting by ligation-mediated PCR

1993 • 24 citations

In Vivo Genomic Footprinting of Thyroid Hormone-Responsive Genes in Pituitary Tumor Cell Lines

1996 • 23 citations

In vivo footprinting of an androgen-dependent enhancer reveals an accessory element integral to hormonal response

1995 • 21 citations

Estrogen receptor-induced DNA bending: orientation of the bend and replacement of an estrogen response element with an intrinsic DNA bending sequence

1995 • 19 citations

Chromatin structure of the MMTV promoter and its changes during hormonal induction

1996 • 15 citations

Estrogen-Dependent Transcriptional Activation and Vitellogenin Gene Memory

1997 • 15 citations