Regulation of pS2 Gene Expression by Affinity Labeling and Reversibly Binding Estrogens and Antiestrogens: Comparison of Effects on the Native Gene and on pS2-Chloramphenicol Acetyltransferase Fusion Genes Transfected into MCF-7 Human Breast Cancer Cells

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

Functional domains of the human estrogen receptor

1987 • 1,316 citations

Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture.

1986 • 1,282 citations

An estrogen-responsive element derived from the 5′ flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells

1986 • 729 citations

Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line

1982 • 727 citations

Estrogenic Regulation of Growth and Polypeptide Growth Factor Secretion in Human Breast Carcinoma

1987 • 576 citations

Proliferation, hormonal responsiveness, and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens.

1987 • 413 citations

Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7.

1984 • 379 citations

Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7

1984 • 304 citations

Ligand-Modulated Regulation of Progesterone Receptor Messenger Ribonucleic Acid and Protein in Human Breast Cancer Cell Lines

1988 • 214 citations

Effects of estrogens and antiestrogens on estrogen receptor dynamics and the induction of progesterone receptor in MCF-7 human breast cancer cells.

1982 • 212 citations

Estrogen and Antiestrogen Action in Reproductive Tissues and Tumors

1979 • 194 citations

Identification of estrogen-responsive DNA sequences by transient expression experiments in a human breast cancer cell line

1986 • 173 citations

A method for increasing the sensitivity of chloramphenicol acetyltransferase assays in extracts of transfected cultured cells

1987 • 161 citations

Efficient and highly selective covalent labeling of the estrogen receptor with [3H]tamoxifen aziridine.

1983 • 154 citations

Promoter Elements of Genes Coding for Proteins and Modulation of Transcription by Estrogens and Progesterone

1984 • 133 citations

Characterization of the Estrogen-Induced pS2 Protein Secreted by the Human Breast Cancer Cell Line MCF-7*

1987 • 125 citations

Steroid Receptor Regulated Transcription of Specific Genes and Gene Networks

1985 • 122 citations

Effects of antiestrogens on the estrogen-regulated pS2 RNA and the 52- and 160-kilodalton proteins in MCF7 cells and two tamoxifen-resistant sublines.

1984 • 120 citations

Structure of the human oestrogen-responsive gene pS2

1987 • 113 citations

Antiestrogen action in breast cancer cells: Modulation of proliferation and protein synthesis, and interaction with estrogen receptors and additional antiestrogen binding sites

1985 • 113 citations

Selective Binding of the Estradiol Receptor to a Region at Least One Kilobase Upstream From the Rat Prolactin Gene

1985 • 112 citations

Poising chromatin for transcription

1987 • 103 citations

Effects of tamoxifen and 4-hydroxytamoxifen on the pNR-1 and pNR-2 estrogen-regulated RNAs in human breast cancer cells.

1987 • 79 citations

Interaction of two nonhistone proteins with the estradiol response element of the avian vitellogenin gene modulates the binding of estradiol-receptor complex.

1987 • 51 citations

Two Different Factors Act Separately or Together To Specify Functionally Distinct Activities at a Single Transcriptional Enhancer

1986 • 40 citations

Regulated expression of the chicken ovalbumin gene in a human estrogen-responsive cell line.

1983 • 35 citations

TAMOXIFEN AZIRIDINES: EFFECTIVE INACTIVATORS OF THE ESTROGEN RECEPTOR

1981 • 29 citations

Estrogenic affinity labels: synthesis, irreversible receptor binding, and bioactivity of aziridine-substituted hexestrol derivatives

1987 • 28 citations

Nuclease resistance and the enrichment of native nuclear acceptor sites for the avian oviduct progesterone receptor.

1986 • 19 citations

Steroidal pure antiestrogens

1991 • 17 citations

Desmethylnafoxidine aziridine: An electrophilic affinity label for the estrogen receptor with high efficiency and selectivity

1987 • 14 citations

Steroid Hormone Regulation of Gene Expression

1985 • 12 citations

Ketononestrol Aziridine, an Agonistic Estrogen Receptor Affinity Label: Study of Its Bioactivity and Estrogen Receptor Covalent Labeling*

1987 • 11 citations