T-Cells, Stress Proteins, and Pathogenesis of Mycobacterial Infections

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1988 • 1,504 citations

Homologous plant and bacterial proteins chaperone oligomeric protein assembly

1988 • 1,316 citations

70K heat shock related proteins stimulate protein translocation into microsomes

1988 • 1,276 citations

Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent.

1986 • 1,116 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium

1985 • 1,025 citations

Proteins as molecular chaperones

1987 • 910 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis

1988 • 838 citations

The Heat Shock Respons

1985 • 809 citations

Lymphocytes bearing antigen-specific γδ T-cell receptors accumulate in human infectious disease lesions

1989 • 592 citations

Isolation of CD4-CD8-mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid

1989 • 543 citations

Major heat shock gene of Drosophila and the Escherichia coli heat-inducible dnaK gene are homologous.

1984 • 513 citations

Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen.

1989 • 492 citations

Stimulation of a major subset of lymphocytes expressing T cell receptor γδ by an antigen derived from mycobacterium tuberculosis

1989 • 491 citations

Activation of γδ T Cells in the Primary Immune Response to Mycobacterium tuberculosis

1989 • 463 citations

Induction of the synthesis of a 70,000 dalton mammalian heat shock protein by the adenovirus E1A gene product

1982 • 454 citations

The Role of Cell-Mediated Immunity in Bacterial Infections

1981 • 452 citations

Stress proteins are immune targets in leprosy and tuberculosis.

1988 • 446 citations

Comparative biology of intracellular parasitism

1985 • 442 citations

Hydrogen peroxide-inducible proteins in Salmonella typhimurium overlap with heat shock and other stress proteins.

1986 • 442 citations

The 65-kilodalton antigen of Mycobacterium tuberculosis

1987 • 391 citations

SYNOVIAL FLUID T CELL REACTIVITY AGAINST 65 kD HEAT SHOCK PROTEIN OF MYCOBACTERIA IN EARLY CHRONIC ARTHRITIS

1988 • 311 citations

T Cells Against a Bacterial Heat Shock Protein Recognize Stressed Macrophages

1989 • 310 citations

The 70-kd mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles.

1985 • 301 citations

The Mycobacterium tuberculosis 65-kilodalton antigen is a heat shock protein which corresponds to common antigen and to the Escherichia coli GroEL protein

1988 • 297 citations

Coming in from the cold

1988 • 285 citations

A role for heat shock proteins in inflammation?

1988 • 262 citations

Characterization, sequence determination, and immunogenicity of a 64-kilodalton protein of Mycobacterium bovis BCG expressed in escherichia coli K-12

1987 • 252 citations

A Highly Evolutionarily Conserved Mitochondrial Protein Is Structurally Related to the Protein Encoded by the Escherichia coli groEL Gene

1988 • 247 citations

A peptide binding protein having a role in antigen presentation is a member of the HSP70 heat shock family.

1989 • 246 citations

Interaction of Hyperthermia and Radiation in CHO Cells: Recovery Kinetics

1976 • 238 citations

T lymphocytes from healthy individuals with specificity to self-epitopes shared by the mycobacterial and human 65-kilodalton heat shock protein.

1989 • 237 citations

Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64‐kDa protein

1987 • 216 citations

Eukaryotic Mr 83,000 heat shock protein has a homologue in Escherichia coli.

1987 • 211 citations

Comparative biology of intracellular parasitism.

1985 • 203 citations

A heat shock operon in Coxiella burnetti produces a major antigen homologous to a protein in both mycobacteria and Escherichia coli

1988 • 198 citations

The recombinant 65-kD heat shock protein of Mycobacterium bovis Bacillus Calmette-Guerin/M. tuberculosis is a target molecule for CD4+ cytotoxic T lymphocytes that lyse human monocytes.

1988 • 189 citations

Induction of cytotoxic T lymphocytes by primary in vitro stimulation with peptides.

1988 • 186 citations

Autoantibodies to the constitutive 73-kD member of the hsp70 family of heat shock proteins in systemic lupus erythematosus.

1988 • 186 citations

Immunochemical characterization of and isolation of the gene for a Borrelia burgdorferi immunodominant 60-kilodalton antigen common to a wide range of bacteria

1988 • 178 citations

A transient thermotolerant survival response produced by single thermal doses in HeLa cells.

1976 • 174 citations

Newcastle disease virus stimulates the cellular accumulation of stress (heat shock) mRNAs and proteins

1982 • 169 citations

Mitogen and lymphokine stimulation of heat shock proteins in T lymphocytes.

1988 • 168 citations

A highly evolutionarily conserved mitochondrial protein is structurally related to the protein encoded by the Escherichia coli groEL gene.

1988 • 163 citations

Autoantibodies to the heat-shock protein hsp90 in systemic lupus erythematosus.

1988 • 158 citations

The 65kDa antigen of mycobacteria—a common bacterial protein?

1987 • 154 citations

Antigenic relatedness of a strongly immunogenic 65 kDA mycobacterial protein antigen with a similarly sized ubiquitous bacterial common antigen

1988 • 152 citations

Mapping of T cell epitopes using recombinant antigens and synthetic peptides.

1987 • 152 citations

Simian virus 40 and polyoma virus induce synthesis of heat shock proteins in permissive cells.

1983 • 148 citations

A recombinant 64 kilodalton protein of Mycobacterium bovis bacillus Calmette-Guerin specifically stimulates human T4 clones reactive to mycobacterial antigens.

1986 • 146 citations

Listeria monocytogenes-reactive T lymphocyte clones with cytolytic activity against infected target cells.

1986 • 134 citations

Activation of cellular stress protein genes by herpes simplex virus temperature-sensitive mutants which overproduce immediate early polypeptides

1982 • 128 citations

Homology of the 70-kilodalton antigens from Mycobacterium leprae and Mycobacterium bovis with the Mycobacterium tuberculosis 71-kilodalton antigen and with the conserved heat shock protein 70 of eucaryotes

1989 • 114 citations

T-Cell Activation

1986 • 102 citations

Herpes simplex virus infection causes the accumulation of a heat-shock protein.

1984 • 102 citations

Human T cell clones recognize two abundant Mycobacterium tuberculosis protein antigens expressed in Escherichia coli.

1987 • 101 citations

Hormone 1 alpha,25-dihydroxyvitamin D3 modulates heat shock response in monocytes

1987 • 96 citations

Parasite heat-shock proteins

1988 • 88 citations

Induction of stress proteins in Sindbis virus- and vesicular stomatitis virus-infected cells

1983 • 74 citations

T cell responses of normal individuals towards recombinant protein antigens of Mycobacterium tuberculosis

1988 • 74 citations

Specific lysis by CD8⁺ T cells of Schwann cells expressing Mycobacterium leprae antigens

1988 • 66 citations

Cloning and Expression of Treponema pallidum Common Antigen (Tp-4) in Escherichia coli K12

1987 • 52 citations

Prediction and identification of an HLA‐DR‐restricted T cell determinant in the 19‐kDa protein of Mycobacteriurn tuberculosis

1988 • 51 citations

The pathology of leprosy.

1978 • 35 citations

Immunity to bacteria and fungi

1989 • 28 citations

Use of synthetic oligopeptides in identification and characterization of immunological functions in the amino acid sequence of the envelope protein of HIV-1.

1989 • 20 citations

Nuclear accumulation of a heat-shock 70-like protein during herpes simplex virus replication

1987 • 19 citations

Towards new leprosy and tuberculosis vaccines.

1987 • 19 citations

Evidence for phagosome-lysosome fusion in Mycobacterium leprae-infected murine Schwann cells

1989 • 17 citations

Immunology of leprosy: new findings, future perspectives

1986 • 12 citations