Regulation of membrane type-matrix metalloproteinases

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 • 1,576 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

ECM and Cell Surface Proteolysis: Regulating Cellular Ecology

1997 • 1,311 citations

MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover

1999 • 1,280 citations

Membrane Type 1 Matrix Metalloproteinase Digests Interstitial Collagens and Other Extracellular Matrix Macromolecules

1997 • 926 citations

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

2000 • 792 citations

Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas

1994 • 769 citations

Matrix metalloproteinases: structures, evolution, and diversification

1998 • 759 citations

Cellular Mechanisms for Human Procollagenase-3 (MMP-13) Activation

1996 • 741 citations

Membrane-Type 1 Matrix Metalloproteinase Cleaves Cd44 and Promotes Cell Migration

2001 • 732 citations

Matrix Metalloproteinases Regulate Neovascularization by Acting as Pericellular Fibrinolysins

1998 • 716 citations

Regulation of Cell Invasion and Morphogenesis in a Three-Dimensional Type I Collagen Matrix by Membrane-Type Matrix Metalloproteinases 1, 2, and 3

2000 • 588 citations

The TIMP2 Membrane Type 1 Metalloproteinase “Receptor” Regulates the Concentration and Efficient Activation of Progelatinase A

1998 • 578 citations

The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic Activation

1996 • 564 citations

Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas.

1995 • 511 citations

Identification of the Second Membrane-type Matrix Metalloproteinase (MT-MMP-2) Gene from a Human Placenta cDNA Library

1995 • 474 citations

Membrane‐Type Matrix Metalloproteinases 1 and 2 Exhibit Broad‐Spectrum Proteolytic Capacities Comparable to Many Matrix Metalloproteinases

1997 • 434 citations

Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis

1995 • 429 citations

Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion

1997 • 419 citations

Transmembrane-deletion Mutants of the Membrane-type Matrix Metalloproteinase-1 Process Progelatinase A and Express Intrinsic Matrix-degrading Activity

1996 • 392 citations

Activation of a recombinant membrane type 1‐matrix metalloproteinase (MT1‐MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)‐2

1996 • 358 citations

Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma.

1996 • 330 citations

Structural properties of matrix metalloproteinases

1999 • 324 citations

cDNA Sequence and mRNA Tissue Distribution of a Novel Human Matrix Metalloproteinase with a Potential Transmembrane Segment

1995 • 319 citations

Binding of Active (57 kDa) Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) to Tissue Inhibitor of Metalloproteinase (TIMP)-2 Regulates MT1-MMP Processing and Pro-MMP-2 Activation

2000 • 310 citations

Regulation of Membrane Type-1 Matrix Metalloproteinase Activation by Proprotein Convertases

2000 • 307 citations

Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) Binds to the Catalytic Domain of the Cell Surface Receptor, Membrane Type 1-Matrix Metalloproteinase 1 (MT1-MMP)

1998 • 285 citations

Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas.

1997 • 281 citations

Differential expression of membrane-type matrix metalloproteinase and its correlation with gelatinase A activation in human malignant brain tumors in vivo and in vitro.

1996 • 278 citations

Expression of membrane-type matrix metalloproteinase in human gastric carcinomas

1995 • 267 citations

Identification and Characterization of the Fifth Membrane-type Matrix Metalloproteinase MT5-MMP

1999 • 261 citations

Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors.

1999 • 257 citations

cDNA Sequence and mRNA Tissue Distribution of a Novel Human Matrix Metalloproteinase with a Potential Transmembrane Segment

1995 • 244 citations

Intermolecular Autolytic Cleavage Can Contribute to the Activation of Progelatinase A by Cell Membranes

1995 • 242 citations

Membrane-type 1 Matrix Metalloprotease (MT1-MMP) Enables Invasive Migration of Glioma Cells in Central Nervous System White Matter

1999 • 236 citations

Matrix-dependent Proteolysis of Surface Transglutaminase by Membrane-type Metalloproteinase Regulates Cancer Cell Adhesion and Locomotion

2001 • 235 citations

The activation of ProMMP-2 (gelatinase A) by HT1080 fibrosarcoma cells is promoted by culture on a fibronectin substrate and is concomitant with an increase in processing of MT1-MMP (MMP-14) to a 45 kDa form

1998 • 228 citations

Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with gelatinase A activation at the cell surface

1998 • 223 citations

Membrane Type 4 Matrix Metalloproteinase (MMP17) Has Tumor Necrosis Factor-α Convertase Activity but Does Not Activate Pro-MMP2

2000 • 218 citations

Tumor and stromal expression of matrix metalloproteinases and their role in tumor progression.

1994 • 200 citations

Role of MT-MMPs and MMP-2 in pancreatic cancer progression

2000 • 197 citations

Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors.

2000 • 195 citations

High levels of MMP-2, MMP-9, MT1-MMP and TIMP-2 mRNA correlate with poor survival in ovarian carcinoma.

1999 • 177 citations

Enhanced expression of tissue inhibitor of metalloproteinase‐2 (TIMP‐2) in the stroma of breast carcinomas correlates with tumor recurrence

1994 • 173 citations

High level of MT-MMP expression is associated with invasiveness of cervical cancer cells

1996 • 165 citations

Membrane‐Type‐2 Matrix Metalloproteinase Can Initiate the Processing of Progelatinase A and is Regulated by the Tissue Inhibitors of Metalloproteinases

1997 • 164 citations

Regulation of Membrane-type-1 Matrix Metalloproteinase Activity by Its Cytoplasmic Domain

2000 • 164 citations

Membrane Type 4 Matrix Metalloproteinase (MT4-MMP, MMP-17) Is a Glycosylphosphatidylinositol-anchored Proteinase

1999 • 163 citations

Mutation Analysis of Membrane Type-1 Matrix Metalloproteinase (MT1-MMP)

2001 • 158 citations

Functional activation of integrin ?v?3 in tumor cells expressing membrane-type 1 matrix metalloproteinase

2000 • 156 citations

Tissue inhibitor of metalloproteinases-4 inhibits but does not support the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase.

2001 • 140 citations

Membrane‐type 6 matrix metalloproteinase (MT6‐MMP, MMP‐25) is the second glycosyl‐phosphatidyl inositol (GPI)‐anchored MMP

2000 • 135 citations

Tissue Inhibitor of Metalloproteinase (TIMP)-2 Acts Synergistically with Synthetic Matrix Metalloproteinase (MMP) Inhibitors but Not with TIMP-4 to Enhance the (Membrane Type 1)-MMP-dependent Activation of Pro-MMP-2

2000 • 135 citations

Expression of tissue inhibitor of matrix metalloproteinase-2 correlates with activation of matrix metalloproteinase-2 and predicts poor prognosis in tongue squamous cell carcinoma

2001 • 130 citations

High levels of TIMP-2 correlate with adverse prognosis in breast cancer

2000 • 123 citations

Expression of membrane-type matrix metalloproteinase 1 (MT1-MMP) in tumor cells enhances pulmonary metastasis in an experimental metastasis assay.

1996 • 121 citations

Protein expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinase 1 and 2 in papillary thyroid carcinomas

2001 • 120 citations

Expression of Three Membrane-type Matrix Metalloproteinases (MT-MMPs) in Rat Vascular Smooth Muscle Cells and Characterization of MT3-MMPs with and without Transmembrane Domain

1997 • 117 citations

Human Tissue Inhibitor of Metalloproteinases 3 Interacts with Both the N- and C-terminal Domains of Gelatinases A and B

1999 • 116 citations

Membrane Type Matrix Metalloproteinase 1 Activates Pro-gelatinase A without Furin Cleavage of the N-terminal Domain

1996 • 114 citations

Increased expression of matrix metalloproteinase 7 and 9 and membrane type 1‐matrix metalloproteinase in esophageal squamous cell carcinomas

2000 • 110 citations

Characterization of a truncated recombinant form of human membrane type 3 matrix metalloproteinase

1999 • 100 citations

Catalytic activities of membrane‐type 6 matrix metalloproteinase (MMP25)

2001 • 91 citations

Membrane type 1-matrix metalloproteinase (MT1-MMP) and MMP-2 immunolocalization in human prostate: change in cellular localization associated with high-grade prostatic intraepithelial neoplasia.

1999 • 91 citations

Roles of membrane type 1 matrix metalloproteinase and tissue inhibitor of metalloproteinases 2 in invasion and dissemination of human malignant glioma

2001 • 91 citations

Differential Roles of TIMP-4 and TIMP-2 in Pro-MMP-2 Activation by MT1-MMP

2001 • 76 citations

Analysis of tissue inhibitor of metalloproteinases-2 effect on pro-matrix metalloproteinase-2 activation by membrane-type 1 matrix metalloproteinase using baculovirus/insect-cell expression system

2000 • 75 citations

Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis.

2000 • 71 citations

Functional characterization of MT3‐MMP in transfected MDCK cells: progelatinase A activation and tubulogenesis in 3‐D collagen lattice

2000 • 54 citations

Membrane-type matrix metalloproteinase-1 expression and activation of gelatinase A as prognostic markers in advanced pediatric neuroblastoma

1999 • 53 citations

Immunohistochemical study of MT-MMP tissue status in gastric carcinoma and correlation with survival analyzed by univariate and multivariate analysis.

1998 • 43 citations

Membrane-type 1 matrix metalloproteinase mRNA expression in colorectal cancer

2000 • 35 citations

Shedding of Membrane Type 1 Matrix Metalloproteinase in a Human Breast Carcinoma Cell Line

1999 • 29 citations

Clinical significance of MT1-MMP mRNA expression in breast cancer

2001 • 24 citations

First Place—Resident Basic Science Award 1998: Role of Membrane Type 1‐Matrix Metalloproteinase and Gelatinase a in Head and Neck Squamous Cell Carcinoma Invasion in Vitro

1999 • 22 citations

Analysis of tissue inhibitor of metalloproteinases-2 effect on pro-matrix metalloproteinase-2 activation by membrane-type 1 matrix metalloproteinase using baculovirus/insect-cell expression system

2000 • 18 citations

Claudin Promotes Activation of Pro-MMP-2 Mediated by Membrane-Type Matrix Metalloproteinases

2003 • 4 citations