Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation

Isolation of Putative Progenitor Endothelial Cells for Angiogenesis

1997 • 8,673 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

1996 • 1,885 citations

A common precursor for hematopoietic and endothelial cells

1998 • 1,433 citations

Pax-6, a murine paired box gene, is expressed in the developing CNS

1991 • 1,226 citations

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

1996 • 1,195 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Ontogeny of the Haemopoietic System: Yolk Sac Origin of In Vivo and In Vitro Colony Forming Cells in the Developing Mouse Embryo*

1970 • 1,031 citations

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse

1999 • 978 citations

Hematopoietic commitment during embryonic stem cell differentiation in culture.

1993 • 919 citations

Expression of the CD34 gene in vascular endothelial cells

1990 • 857 citations

Expression pattern of the mouse T gene and its role in mesoderm formation

1990 • 854 citations

Progressive lineage analysis by cell sorting and culture identifies FLK1+VEcadherin+ cells at a diverging point of endothelial and hemopoietic lineages

1998 • 830 citations

Wnt-3a regulates somite and tailbud formation in the mouse embryo.

1994 • 784 citations

Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

1999 • 773 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

The T Cell Leukemia Oncoprotein SCL/tal-1 Is Essential for Development of All Hematopoietic Lineages

1996 • 746 citations

flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors

1993 • 707 citations

Bone morphogenetic proteins in development

2004 • 678 citations

A common precursor for primitive erythropoiesis and definitive haematopoiesis

1997 • 601 citations

Mouse gastrulation: the formation of a mammalian body plan

1997 • 595 citations

Erythropoietin receptor mRNA expression in human endothelial cells.

1994 • 584 citations

Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.

1995 • 582 citations

Inhibition of Wnt activity induces heart formation from posterior mesoderm

2001 • 581 citations

T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification

1999 • 510 citations

Embryonic stem cells differentiate in vitro to endothelial cells through successive maturation steps

1996 • 479 citations

Wnt antagonism initiates cardiogenesis in Xenopus laevis

2001 • 479 citations

Evidence for Involvement of Activin A and Bone Morphogenetic Protein 4 in Mammalian Mesoderm and Hematopoietic Development

1995 • 464 citations

Studies on the origin of blood vessels and of red corpuscles as seen in the living blastoderm of the chick during the second day of incubation

1920 • 457 citations

The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo

1999 • 392 citations

nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation

1997 • 384 citations

The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif.

1989 • 363 citations

Flk-1 expression defines a population of early embryonic hematopoietic precursors

1990 • 363 citations

Expression pattern of the Brachyury gene in whole-mount T WIS/T WIS mutant embryos

1991 • 350 citations

Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium.

1994 • 315 citations

The SCL/TAL-1 gene is expressed in progenitors of both the hematopoietic and vascular systems during embryogenesis

1994 • 295 citations

Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro

2002 • 294 citations

Expression of the fibroblast growth factor-5 gene in the mouse embryo

1991 • 264 citations

Specific expression of a retinoic acid-regulated, zinc-finger gene, Rex-1, in preimplantation embryos, trophoblast and spermatocytes

1991 • 262 citations

A transitional stage in the commitment of mesoderm to hematopoiesis requiring the transcription factor SCL/tal-1

2000 • 247 citations

The sialomucin CD34 is expressed on hematopoietic cells and blood vessels during murine development

1995 • 240 citations

Basic fibroblast growth factor positively regulates hematopoietic development

2000 • 226 citations

In vitro hematopoietic and endothelial potential of flk-1 ^−/− embryonic stem cells and embryos

1999 • 224 citations

Immunohistochemical Analysis of the Brachyury Protein in Wild-Type and Mutant Mouse Embryos

1994 • 218 citations

Nonsense-Mediated mRNA Decay

2006 • 195 citations

mRNA localization studies suggest that murine FGF-5 plays a role in gastrulation

1991 • 189 citations

Lineage analysis of the hemangioblast as defined by FLK1 and SCL expression

2002 • 183 citations

Nonsense-mediated mRNA decay

2002 • 106 citations

A new mouse member of the Wnt gene family, mWnt-8, is expressed during early embryogenesis and is ectopically induced by retinoic acid

1996 • 96 citations

Regulation of vertebrate neural cell fate by transcription factors

1996 • 81 citations

Inner Cell Mass-Specific Expression of a Cell Adhesion Molecule (PECAM-1/CD31) in the Mouse Blastocyst

2001 • 75 citations