Decrease in δ-opioid receptor density in rat brain after chronic [d-Ala2,d-Leu5]enkephalin treatment

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines.

1953 • 1,702 citations

The Up-and-Down Method for Small Samples

1965 • 795 citations

U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist.

1983 • 795 citations

Morphine Action at Central Nervous System Sites in Rat: Analgesia or Hyperalgesia Depending on Site and Dose

1973 • 279 citations

On the central sites for the antinociceptive action of morphine and fentanyl

1970 • 265 citations

Mu and delta receptors: Their role in analgesia and in the differential effects of opioid peptides on analgesia

1982 • 233 citations

Novel opiate binding sites selective for benzomorphan drugs.

1981 • 225 citations

Opiate receptor down-regulation and desensitization in neuroblastoma X glioma NG108-15 hybrid cells are two separate cellular adaptation processes.

1983 • 211 citations

Narcotic Receptor Sites in Morphine-dependent Rats

1974 • 201 citations

Naltrexone-induced opiate receptor supersensitivity

1982 • 195 citations

Properties of a selective kappa agonist, U-50,488H

1982 • 195 citations

Specificity of opioids towards the μ-, δ- and ϵ-opiate receptors

1979 • 194 citations

STUDIES ON THE SITE OF ANALGESIC ACTION OF MORPHINE BY INTRACEREBRAL MICRO-INJECTION.

1964 • 173 citations

In vivo evidence for multiple opiate receptors mediating analgesia in the rat spinal cord

1982 • 148 citations

Opioid δ-receptor involvement in supraspinal and spinal antinociception in mice

1987 • 139 citations

In vivo studies on spinal opiate receptor systems mediating antinociception. I. Mu and delta receptor profiles in the primate.

1983 • 133 citations

Opioid peptides induce reduction of enkephalin receptors in cultured neuroblastoma cells

1982 • 130 citations

Selective development of tolerance without dependence in multiple opiate receptors of mouse vas deferens

1980 • 129 citations

Decrease in delta and mu opioid receptor binding capacity in rat brain after chronic etorphine treatment.

1987 • 122 citations

Loss of opiate receptor activity in neuroblastoma X glioma NG108-15 hybrid cells after chronic opiate treatment. A multiple-step process.

1982 • 122 citations

STUDIES ON THE SITE OF ANALGESIC ACTION OF MORPHINE BY INTRACEREBRAL MICRO-INJECTION

1965 • 120 citations

Binding of 3H-naloxone in the mouse brain: Effect of ions and tolerance development

1974 • 113 citations

Comparison of in vivo and in vitro parameters of opiate receptor binding in naive and tolerant/dependent rodents

1975 • 108 citations

Opiate receptor binding—enhancement by opiate administration in vivo

1976 • 104 citations

Supersensitivity of brain opiate receptor subtypes after chronic naltrexone treatment

1982 • 87 citations

Lack of cross-tolerance on multiple opiate receptors in the mouse vas deferens.

1980 • 62 citations

Down regulation of δ but not μ opioid receptors in the hippocampal slice associated with loss of physiological response

1983 • 60 citations

In vitro studies on opiate receptors and their ligands.

1978 • 58 citations

Characterization of the association of tritiated enkephalin with neuroblastoma cells under conditions optimal for receptor down regulation.

1983 • 51 citations

Regional sensitivity of the rat brain to the inhibitory effects of morphine on wet shake behavior.

1975 • 48 citations

Tolerance and cross tolerance to morphine after chronic spinal D-Ala2-D-Leu5-enkephalin infusion

1982 • 41 citations

Interaction between morphine and morphine antagonists after systematic and intraventricular application

1970 • 22 citations