Inhalation of carbon monoxide prevents liver injury and inflammation following hind limb ischemia/reperfusion

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

1992 • 12,726 citations

Bilirubin Is an Antioxidant of Possible Physiological Importance

1987 • 3,406 citations

Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

2000 • 2,074 citations

The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.

1968 • 1,767 citations

The epidemiology of the systemic inflammatory response

2000 • 529 citations

Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis

2001 • 396 citations

Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver.

1995 • 388 citations

Influence of Systemic Inflammatory Response Syndrome and Sepsis on Outcome of Critically Ill Infected Patients

2003 • 262 citations

Vascular Adhesion Protein-1 Mediates Adhesion and Transmigration of Lymphocytes on Human Hepatic Endothelial Cells

2002 • 234 citations

Heme Induces the Expression of Adhesion Molecules ICAM-1, VCAM-1, and E Selectin in Vascular Endothelial Cells

1997 • 225 citations

Carbon Monoxide Induces Cytoprotection in Rat Orthotopic Lung Transplantation via Anti-Inflammatory and Anti-Apoptotic Effects

2003 • 219 citations

The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase

1995 • 219 citations

Inflammatory mediators in relation to the development of multiple organ failure in patients after severe blunt trauma

1995 • 217 citations

Carbon Monoxide Protects against Liver Failure through Nitric Oxide–induced Heme Oxygenase 1

2003 • 212 citations

Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice

2001 • 194 citations

Carbon Monoxide Inhalation Protects Rat Intestinal Grafts from Ischemia/Reperfusion Injury

2003 • 192 citations

Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver

2004 • 174 citations

Carbon Monoxide Modulates Fas/Fas Ligand, Caspases, and Bcl-2 Family Proteins via the p38α Mitogen-activated Protein Kinase Pathway during Ischemia-Reperfusion Lung Injury

2003 • 170 citations

Protective role of endogenous carbon monoxide in hepatic microcirculatory dysfunction after hemorrhagic shock in rats.

1998 • 164 citations

Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice

2003 • 163 citations

Heme oxygenase modulates selectin expression in different regional vascular beds

2000 • 158 citations

Inhaled carbon monoxide suppresses the development of postoperative ileus in the murine small intestine

2003 • 149 citations

Differential effects of heme oxygenase isoforms on heme mediation of endothelial intracellular adhesion molecule 1 expression.

1999 • 145 citations

Modulation of cyclic guanosine monophosphate levels in cultured aortic smooth muscle cells by carbon monoxide

1989 • 136 citations

Carbon monoxide relaxes ileal smooth muscle through activation of guanylate cyclase

1991 • 126 citations

Bilirubin rinse: A simple protectant against the rat liver graft injury mimicking heme oxygenase-1 preconditioning

2003 • 102 citations

Molecular mechanisms of tumor necrosis factorα–stimulated leukocyte recruitment into the murine hepatic circulation

2000 • 100 citations

Differential expression pattern of heme oxygenase-1/heat shock protein 32 and nitric oxide synthase-II and their impact on liver injury in a rat model of hemorrhage and resuscitation

1999 • 93 citations

A novel strategy against ischemia and reperfusion injury: cytoprotection with heme oxygenase system

2002 • 87 citations

A novel nitric oxide scavenger decreases liver injury and improves survival after hemorrhagic shock

1999 • 80 citations

Hepatic Dysfunction Increases Length of Stay and Risk of Death after Injury

2002 • 72 citations

Protective Effects of Heme Oxygenase-1 in Acute Lung Injury

1999 • 68 citations

Endothelin-1 and heme oxygenase-1 as modulators of sinusoidal tone in the stress-exposed rat liver

2002 • 56 citations

Involvement of Kupffer Cells in the Interaction Between Neutrophils and Sinusoidal Endothelial Cells in Rats

2002 • 48 citations

The Impact of Liver Dysfunction on Outcome in Patients with Multiple Injuries

2001 • 48 citations

Initiation of remote hepatic injury in the rat: Interactions between Kupffer cells, tumor necrosis factor-α, and microvascular perfusion

1999 • 48 citations

Carbon Monoxide Modulates Endotoxin-induced Microvascular Leukocyte Adhesion through Platelet-dependent Mechanisms

2002 • 43 citations

Inhibition of haem oxygenase activity increases leukocyte accumulation in the liver following limb ischaemia‐reperfusion in mice

2002 • 42 citations

Endothelin-1 and heme oxygenase-1 as modulators of sinusoidal tone in the stress-exposed rat liver

2002 • 38 citations

Cytokines contribute to early hepatic parenchymal injury and microvascular dysfunction after bilateral hindlimb ischemia

1999 • 38 citations

Heme oxygenase-1: A cellular Hercules

2003 • 37 citations

Biliverdin protects rat livers from Ischemia/Reperfusion injury

2003 • 32 citations

Kupffer cell-initiated remote hepatic injury following bilateral hindlimb ischemia is complement dependent

2001 • 27 citations

Microcirculatory perfusion deficits are not essential for remote parenchymal injury within the liver

1999 • 26 citations

Inhibition of Heme Oxygenase Ameliorates Sepsis-Induced Liver Dysfunction in Rats

2003 • 23 citations

Regulation of Heme Oxygenase-1 Gene Expression by Anoxia and Reoxygenation in Primary Rat Hepatocyte Cultures

2003 • 23 citations

The role of endogenous heme oxygenase in the initiation of liver injury following limb ischemia/reperfusion

2002 • 21 citations

Cotransfection of heme oxygenase-1 prevents the acute inflammation elicited by a second adenovirus

2003 • 16 citations

Allopurinol inhibits CXC chemokine expression and leukocyte adhesion in endotoxemic liver injury

2003 • 15 citations

Hepatic leukocyte recruitment in a model of acute colitis

2002 • 13 citations

The gene expression of cytokines and chemokines induced by tourniquet shock in mice

2003 • 8 citations