Correction of Alternative Splicing of Tau in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.

2000 • 1,878 citations

Mutation-Specific Functional Impairments in Distinct Tau Isoforms of Hereditary FTDP-17

1998 • 954 citations

Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization.

1990 • 849 citations

Tau protein pathology in neurodegenerative diseases

1998 • 674 citations

Frontotemporal dementia and parkinsonism linked to chromosome 17: A consensus conference

1997 • 626 citations

Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors

1994 • 612 citations

Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements

1999 • 506 citations

Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins

1998 • 505 citations

A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes

2001 • 480 citations

The microtubule binding domain of tau protein

1989 • 472 citations

Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

1998 • 464 citations

Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau

1994 • 391 citations

Genetic evidence for the involvement of τ in progressive supranuclear palsy

1997 • 387 citations

Antisense-induced exon skipping and synthesis of dystrophin in the mdx mouse

2000 • 371 citations

Structure, Microtubule Interactions, and Paired Helical Filament Aggregation by Tau Mutants of Frontotemporal Dementias

2000 • 337 citations

5′ Splice Site Mutations in tau Associated with the Inherited Dementia FTDP-17 Affect a Stem-Loop Structure That Regulates Alternative Splicing of Exon 10

1999 • 294 citations

The Regulation of Splice-Site Selection, and Its Role in Human Disease

1997 • 277 citations

Tau Mutations Cause Frontotemporal Dementias

1998 • 267 citations

Filamentous nerve cell inclusions in neurodegenerative diseases

1998 • 261 citations

Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17

1999 • 247 citations

Modification of splicing in the dystrophin gene in cultured Mdx muscle cells by antisense oligoribonucleotides

1998 • 241 citations

Abnormal Tau proteins in progressive supranuclear palsy

1991 • 235 citations

Repair of thalassemic human β-globin mRNA in mammalian cells by antisense oligonucleotides

1996 • 233 citations

Structural and Functional Differences between 3-Repeat and 4-Repeat Tau Isoforms

2000 • 218 citations

Specific removal of the nonsense mutation from the mdx dystrophin mRNA using antisense oligonucleotides

1999 • 208 citations

FTDP‐17 mutations N279K and S305N in tau produce increased splicing of exon 10

1999 • 203 citations

Induction of endogenous Bcl-xS through the control of Bcl-x pre-mRNA splicing by antisense oligonucleotides

1999 • 200 citations

The fibronectin gene as a model for splicing and transcription studies

1996 • 198 citations

Microtubule bundling by tau proteins in vivo: analysis of functional domains.

1992 • 186 citations

Structure of tau protein and assembly into paired helical filaments

2000 • 161 citations

Restoration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic patients

2000 • 155 citations

Correction of Aberrant Splicing of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene by Antisense Oligonucleotides

1999 • 148 citations

RNA processing and human disease

2000 • 135 citations

Determinants of 4-Repeat Tau Expression

2000 • 129 citations

Alternative splicing of human genes: more the rule than the exception?

1999 • 125 citations

Competition for Microtubule-binding with Dual Expression of Tau Missense and Splice Isoforms

2001 • 117 citations

Probing the structure and function of U2 snRNP with antisense oligonucleotides made of 2′-OMe RNA

1989 • 115 citations

Progressive supranuclear gaze palsy is in linkage disequilibrium with theτ and not the α-synuclein gene

1998 • 93 citations

Complex Regulation of Tau Exon 10, Whose Missplicing Causes Frontotemporal Dementia

2000 • 88 citations

Tau isoform expression and phosphorylation state during differentiation of cultured neuronal cells

1995 • 82 citations

Identification of a Bidirectional Splicing Enhancer: Differential Involvement of SR Proteins in 5′ or 3′ Splice Site Activation

1999 • 78 citations

Expression of specific tau exons in normal and tumoral pancreatic acinar cells

1998 • 51 citations

A double-labeling immunohistochemical study of tau exon 10 in Alzheimer's disease, progressive supranuclear palsy and Pick's disease

2000 • 43 citations

ARP3β, the gene encoding a new human actin‐related protein, is alternatively spliced and predominantly expressed in brain neuronal cells

2000 • 32 citations

The tangled biology of tau

1999 • 25 citations