Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice.

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

1992 • 839 citations

Functional diversity of T lymphocytes due to secretion of different cytokine patterns

1991 • 530 citations

Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.

1993 • 506 citations

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.

1993 • 410 citations

Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice

1989 • 385 citations

Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.

1992 • 339 citations

Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr/lpr mice.

1980 • 331 citations

Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene.

1993 • 287 citations

The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn.

1993 • 241 citations

An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity.

1991 • 198 citations

Deletion of potentially self-reactive T cell receptor specificities in L3T4-, Lyt-2- T cells of lpr mice.

1988 • 142 citations

Influence of thymic genotype on the systemic lupus erythematosus-like disease and T cell proliferation of MRL/Mp-lpr/lpr mice.

1981 • 128 citations

Tolerance-related V beta clonal deletions in normal CD4-8-, TCR-alpha/beta + and abnormal lpr and gld cell populations.

1989 • 127 citations

Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells.

1989 • 118 citations

CS-A therapy in MRL-lpr/lpr mice: amelioration of immunopathology despite autoantibody production.

1987 • 113 citations

Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice. Clues from a T cell receptor beta transgenic mouse.

1993 • 98 citations

Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice.

1991 • 97 citations

Treatment of murine lupus with F(ab')2 fragments of monoclonal antibody to L3T4. Suppression of autoimmunity does not depend on T helper cell depletion.

1989 • 88 citations

Evidence for an intrinsic B cell defect in lpr/lpr mice apparent in neonatal chimeras.

1990 • 76 citations

Defective maintenance of T cell tolerance to a superantigen in MRL-lpr/lpr mice.

1992 • 71 citations

Transgenic rearranged T cell receptor gene inhibits lymphadenopathy and accumulation of CD4-CD8-B220+ T cells in lpr/lpr mice.

1990 • 64 citations

Altered expression of self-reactive T cell receptor V beta regions in autoimmune mice.

1990 • 60 citations

lpr T cells are necessary for autoantibody production in lpr mice.

1993 • 60 citations

Defect in negative selection in lpr donor-derived T cells differentiating in non-lpr host thymus.

1991 • 47 citations

Expression and ontogeny of CD2 on murine B cells.

1990 • 44 citations

Deletion analysis of the human CD2 gene locus control region in transgenic mice

1991 • 41 citations

MRL mice produce anti-Su autoantibody, a specificity associated with systemic lupus erythematosus.

1993 • 22 citations

Production of Transgenic Mice and Application to Immunology and Autoimmunity

1990 • 10 citations