Ets-1 is a critical regulator of Ang II-mediated vascular inflammation and remodeling

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Absence of Monocyte Chemoattractant Protein-1 Reduces Atherosclerosis in Low Density Lipoprotein Receptor–Deficient Mice

1998 • 1,569 citations

Chemokines and disease

2001 • 1,371 citations

Vasculogenesis

1995 • 1,344 citations

Vascular Remodeling in Hypertension

2001 • 928 citations

The Ets family of transcription factors

1993 • 848 citations

Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure

1999 • 790 citations

Tissue Angiotensin and Pathobiology of Vascular Disease

2001 • 750 citations

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

1995 • 737 citations

Endogenous Activation of Latent Collagenase by Rheumatoid Synovial Cells

1977 • 686 citations

The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin

1996 • 680 citations

The renin-angiotensin-aldosterone system

1978 • 606 citations

Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.

1989 • 579 citations

Angiotensin II Stimulates Endothelial Vascular Cell Adhesion Molecule-1 via Nuclear Factor-κB Activation Induced by Intracellular Oxidative Stress

2000 • 510 citations

Angiotensin Induces Inflammatory Activation of Human Vascular Smooth Muscle Cells

1999 • 483 citations

Angiotensin II Induces Monocyte Chemoattractant Protein-1 Gene Expression in Rat Vascular Smooth Muscle Cells

1998 • 388 citations

Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling

2002 • 386 citations

Mutation of MEF2A in an Inherited Disorder with Features of Coronary Artery Disease

2003 • 382 citations

Angiotensin II Induces Vascular Cell Adhesion Molecule-1 Expression In Rat Vasculature

1999 • 376 citations

Angiotensin II Induces Interleukin-6 Transcription in Vascular Smooth Muscle Cells Through Pleiotropic Activation of Nuclear Factor-κB Transcription Factors

1999 • 374 citations

Angiotensin II–Induced Hypertension Accelerates the Development of Atherosclerosis in ApoE-Deficient Mice

2001 • 361 citations

The Ets-1 Transcription Factor Is Required for the Development of Natural Killer Cells in Mice

1998 • 351 citations

Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats.

1997 • 332 citations

Defective activation and survival of T cells lacking the Ets-1 transcription factor

1995 • 329 citations

Transcriptional Regulation of The Human Monocyte Chemoattractant Protein-1 Gene

1997 • 317 citations

Role of JNK, p38, and ERK in Platelet-Derived Growth Factor–Induced Vascular Proliferation, Migration, and Gene Expression

2003 • 300 citations

Cooperative Interaction of Hypoxia-inducible Factor-2α (HIF-2α) and Ets-1 in the Transcriptional Activation of Vascular Endothelial Growth Factor Receptor-2 (Flk-1)

2003 • 266 citations

The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data

2001 • 262 citations

Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide

2001 • 256 citations

Monocyte Chemoattractant Protein-1 Expression in Aortic Tissues of Hypertensive Rats

1997 • 220 citations

Critical Role of Monocyte Chemoattractant Protein-1 Receptor CCR2 on Monocytes in Hypertension-Induced Vascular Inflammation and Remodeling

2004 • 214 citations

ETS-1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin ?3

1999 • 210 citations

Angiotensin II induces c-fos expression in smooth muscle via transcriptional control.

1989 • 206 citations

Modulation of plasminogen activator inhibitor-1 in vivo: A new mechanism for the anti-fibrotic effect of renin-angiotensin inhibition

1997 • 199 citations

Plasminogen Activator Inhibitor-1 Is a Major Determinant of Arterial Thrombolysis Resistance

1999 • 182 citations

Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse.

1995 • 165 citations

Important Role of Local Angiotensin II Activity Mediated via Type 1 Receptor in the Pathogenesis of Cardiovascular Inflammatory Changes Induced by Chronic Blockade of Nitric Oxide Synthesis in Rats

2000 • 163 citations

Plasminogen Activator Inhibitor-1 Deficiency Prevents Hypertension and Vascular Fibrosis in Response to Long-term Nitric Oxide Synthase Inhibition

2001 • 159 citations

Bone Marrow–Derived Monocyte Chemoattractant Protein-1 Receptor CCR2 Is Critical in Angiotensin II–Induced Acceleration of Atherosclerosis and Aneurysm Formation in Hypercholesterolemic Mice

2004 • 157 citations

A pitfall of using a second plasmid to determine transfection efficiency

1992 • 150 citations

CC Chemokine Receptor 2 Is Required for Macrophage Infiltration and Vascular Hypertrophy in Angiotensin II–Induced Hypertension

2000 • 150 citations

A cAMP Response Element and an Ets Motif Are Involved in the Transcriptional Regulation of flt-1 Tyrosine Kinase (Vascular Endothelial Growth Factor Receptor 1) Gene

1996 • 149 citations

TNFα induces expression of transcription factors c-fos, Egr-1, and Ets-1 in vascular lesions through extracellular signal-regulated kinases 1/2

2001 • 135 citations

xIAP Induces Cell-Cycle Arrest and Activates Nuclear Factor-κB

2001 • 135 citations

Differential Regulation of P27Kip1 Expression by Mitogenic and Hypertrophic Factors

2000 • 129 citations

Reactive Oxygen Intermediates Mediate Angiotensin II-induced c-Jun•c-Fos Heterodimer DNA Binding Activity and Proliferative Hypertrophic Responses in Myogenic Cells

1995 • 122 citations

Ets-1 is an early response gene activated by ET-1 and PDGF-BB in vascular smooth muscle cells

1998 • 118 citations

Role of Monocyte Chemoattractant Protein-1 in Cardiovascular Remodeling Induced by Chronic Blockade of Nitric Oxide Synthesis

2000 • 104 citations

Monocyte Chemoattractant Protein-1 Is an Essential Inflammatory Mediator in Angiotensin II-Induced Progression of Established Atherosclerosis in Hypercholesterolemic Mice

2004 • 103 citations

Role of the Ets Transcription Factors in the Regulation of the Vascular-Specific Tie2 Gene

1999 • 98 citations

Regulated Expression of the Ets-1 Transcription Factor in Vascular Smooth Muscle Cells In Vivo and In Vitro

1996 • 93 citations

Effect of Angiotensin II Type 1 Receptor Blockade on Cardiac Remodeling in Angiotensin II Type 2 Receptor Null Mice

2002 • 88 citations

Characterization of NERF, a Novel Transcription Factor Related to the Ets Factor ELF-1

1996 • 86 citations

Angiogenesis inhibition by transdominant mutant Ets-1

2000 • 62 citations

Ets-1 Protects Vascular Smooth Muscle Cells from Undergoing Apoptosis by Activating p21WAF1/Cip1

2003 • 52 citations

Sodium restriction prevents cardiac hypertrophy and oxidative stress in angiotensin II hypertension

2003 • 52 citations

Role of Transcription Factors in Angiogenesis

2001 • 48 citations

Transcriptional regulation of human angiopoietin-2 by transcription factor Ets-1

2004 • 47 citations

Angiotensin II and structural remodeling of coronary vessels in rats.

1994 • 44 citations

Myocyte Enhancer Factor 2 Mediates Vascular Inflammation via the p38-Dependent Pathway

2004 • 38 citations

Elevated intracardiac angiotensin II leads to cardiac hypertrophy and mechanical dysfunction in normotensive mice

2003 • 37 citations

In Vivo Evidence of the Importance of Cardiac Angiotensin-Converting Enzyme in the Pathogenesis of Cardiac Hypertrophy

2000 • 36 citations

Potential Roles of Plasminogen Activator System in Coronary Vascular Remodeling Induced by Long-term Nitric Oxide Synthase Inhibition

2002 • 34 citations

Angiotensin II induces formation of the early growth response gene‐1 protein in rat vascular smooth muscle cells

1992 • 18 citations

Induction of Apoptosis after Stent Implantation in Canine Portal Vein

2002 • 5 citations