Tumor Promotion by Inhibitors of ProteinZ Phosphatases 1 and 2A: The Okadaic Acid Class of Compounds

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

ras GENES

1987 • 3,818 citations

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Tumor Necrosis Factor (TNF)

1985 • 1,932 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

Cyanobacterial microcystin‐LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants

1990 • 1,627 citations

Toxic Marine Phytoplankton

1987 • 1,559 citations

MOLECULAR AND CELLULAR BIOLOGY OF INTERMEDIATE FILAMENTS

1988 • 1,395 citations

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

Calyculin A and okadaic acid: Inhibitors of protein phosphatase activity

1989 • 1,032 citations

Molecular cloning and expression of a receptor for human tumor necrosis factor

1990 • 973 citations

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

1990 • 918 citations

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

1986 • 865 citations

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

1989 • 848 citations

Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR

1992 • 817 citations

TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR

1988 • 814 citations

Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria

1981 • 742 citations

Diarrhetic shellfish toxins

1985 • 626 citations

Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter.

1988 • 595 citations

Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases.

1990 • 589 citations

Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A

1990 • 586 citations

Poisonous Australian Lake

1878 • 582 citations

Inhibition of protein phosphatases by microcystis and nodularin associated with hepatotoxicity

1990 • 579 citations

Tumor necrosis factor.

1991 • 568 citations

Nodularin, microcystin, and the configuration of Adda

1988 • 540 citations

Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor-promoting agents.

1975 • 504 citations

jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun

1989 • 488 citations

Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors

1991 • 468 citations

Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture.

1988 • 430 citations

Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene

1983 • 429 citations

Regulation of Progesterone Receptor-Mediated Transcription by Phosphorylation

1990 • 365 citations

Naming of cyclic heptapeptide toxins of cyanobacteria (blue-green algae)

1988 • 360 citations

Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant.

1987 • 360 citations

Evidence of liver damage by toxin from a bloom of the blue‐green alga, Microcystis aeruginosa

1983 • 353 citations

Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatases

1990 • 340 citations

The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells

1991 • 330 citations

Intermediate filament reorganization during mitosis is mediated by p34cdc2 phosphorylation of vimentin

1990 • 328 citations

The origins of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment--twenty-seventh G.H.A. Clowes memorial award lecture.

1988 • 326 citations

The structure of cyanoginosin-LA, a cyclic heptapeptide toxin from the cyanobacterium Microcystis aeruginosa

1984 • 325 citations

Bioactive marine metabolites. Part 16. Calyculin A. A novel antitumor metabolite from the marine sponge Discodermia calyx

1986 • 299 citations

Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin

1987 • 280 citations

Isolation and structural elucidation of the causative toxin of the diarrhetic shellfish poisoning.

1982 • 280 citations

The Water Environment: Algal Toxins And Health

2011 • 270 citations

Identification of 12 hepatotoxins from a Homer Lake bloom of the cyanobacteria Microcystis aeruginosa, Microcystis viridis, and Microcystis wesenbergii: nine new microcystins

1992 • 260 citations

Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters.

1981 • 254 citations

Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated guinea-pig cardiac myocytes

1988 • 249 citations

The role of the κ enhancer and its binding factor NF-κB in the developmental regulation of κ gene transcription

1987 • 247 citations

Modulation of fibroblast functions by interleukin 1: increased steady-state accumulation of type I procollagen messenger RNAs and stimulation of other functions but not chemotaxis by human recombinant interleukin 1 alpha and beta

1988 • 243 citations

Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoyl-phorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis.

1977 • 234 citations

Hepatocellular uptake of 3H-dihydromicrocystin-LR, a cyclic peptide toxin

1990 • 224 citations

Mycotoxins and phycotoxins

1988 • 221 citations

Association of protein phosphatase 2A with polyoma virus medium tumor antigen.

1990 • 221 citations

and effects of protein phosphatase inhibitors, microcystins and nodularin, on mouse skin and fibroblasts

1990 • 197 citations

Protein kinase C-independent activation of nuclear factor kappa B by tumor necrosis factor.

1990 • 193 citations

Tautomycin from the bacterium Streptomyces verticillatus

1990 • 191 citations

The biology and medicine of signal transduction

1991 • 185 citations

Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal.

1990 • 183 citations

Okadaic acid, a specific protein phosphatase inhibitor, induces maturation and MPF formation in Xenopus laevis oocytes

1989 • 179 citations

Analysis and purification of toxic peptides from cyanobacteria by reversed-phase high-performance liquid chromatography

1988 • 178 citations

Cytoskeletal integrity in interphase cells requires protein phosphatase activity.

1992 • 174 citations

Histopathological studies on experimental marine toxin poisoning. I. Ultrastructural changes in the small intestine and liver of suckling mice induced by dinophysistoxin-1 and pectenotoxin-1

1986 • 162 citations

Interleukin 1 and tumor necrosis factor activate common multiple protein kinases in human fibroblasts

1991 • 160 citations

Toxicity and partial structure of a hepatotoxic peptide produced by the cyanobacterium Nodularia spumigena Mertens emend. L575 from New Zealand

1988 • 158 citations

Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin.

1990 • 156 citations

Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen.

1991 • 149 citations

Isolation and characterization of the minor components associated with microcystins LR and RR in the cyanobacterium (blue-green algae)

1990 • 147 citations

Structural determination of geometrical isomers of microcystins LR and RR from cyanobacteria by two-dimensional NMR spectroscopic techniques

1990 • 145 citations

Toxins contained in Microcystis species of cyanobacteria (blue-green algae)

1988 • 144 citations

Structure-activity relationship within a series of okadaic acid derivatives

1990 • 139 citations

Tissue Distribution, Excretion, and Hepatic Biotransformation of Microcystin-LR in Mice

1990 • 139 citations

Studies in Natural Products Chemistry

2024 • 138 citations

Okadaic acid mimics multiple changes in early protein phosphorylation and gene expression induced by tumor necrosis factor or interleukin-1.

1992 • 138 citations

Structural characterization of toxic cyclic peptides from blue-green algae by tandem mass spectrometry.

1989 • 133 citations

Diarrhetic Shellfish Toxin, Dinophysistoxin‐1, Is a Potent Tumor Promoter on Mouse Skin

1988 • 129 citations

Cyanobacterial nodularin is a potent inhibitor of type 1 and type 2A protein phosphatases.

1991 • 129 citations

Phosphorylation of intermediate filament proteins by cAMP-dependent protein kinases

1981 • 128 citations

Structure‐Function Relationships of Microcystins, Liver Tumor Promoters, in Interaction with Protein Phosphatase

1991 • 121 citations

Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumor promoter, in primary cultured rat hepatocytes

1992 • 121 citations

Cell cycle oscillation of phosphatase inhibitor-2 in rat fibroblasts coincident with p34cdc2 restriction

1990 • 120 citations

Calcium-independent activation of contractile apparatus in smooth muscle by calyculin-A.

1989 • 114 citations

When worlds collide: Immunosuppressants meet protein phosphatases

1991 • 114 citations

A new antibiotic, tautomycin.

1987 • 112 citations

Bioactive marine metabolites. 24. Isolation and structure elucidation of calyculins B, C, and D, novel antitumor metabolites, from the marine sponge Discodermia calyx

1988 • 105 citations

Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity

1992 • 100 citations

Calyculin‐A increases the level of protein phosphorylation and changes the shape of 3T3 fibroblasts

1991 • 99 citations

Characterization of chemically tritiated microcystin-LR and its distribution in mice

1989 • 96 citations

Specific protein dephosphorylation in apoptosis induced by ionizing radiation and heat shock in human lymphoid tumor lines.

1992 • 95 citations

Inhibition of protein phosphatases by okadaic acid induces AP1 in human T cells

1991 • 94 citations

Acanthifolicin, a new episulfide-containing polyether carboxylic acid from extracts of the marine sponge Pandaros acanthifolium

1981 • 92 citations

Apparent “activation” of protein kinases by okadaic acid class tumor promoters

1989 • 87 citations

Calyculins E, F, G, and H, additional inhibitors of protein phosphatases 1 and 2a, from the marine sponge discodermia calyx

1991 • 85 citations

Contractile effects of okadaic acid, a novel ionophore-like substance from black sponge, on isolated smooth muscles under the condition of Ca deficiency.

1982 • 83 citations

Relevance Of Animal Studies To The Evaluation Of Human Cancer Risk

1992 • 79 citations

Teleocidin from Streptomyces is a potent promoter of mouse skin carcinogenesis

1982 • 74 citations

A novel protein phosphatase inhibitor, tautomycin Effect on smooth muscle

1991 • 71 citations

Regulation of gene expression by tumor promoters

1990 • 70 citations

Induction of nuclear factor-kappa B and the human immunodeficiency virus long terminal repeat by okadaic acid, a specific inhibitor of phosphatases 1 and 2A.

1990 • 67 citations

Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases.

1990 • 66 citations

Specific binding ofadaic acid, a new tumor promoter in mouse skin

1989 • 63 citations

Hyperphosphorylation of retinoblastoma protein and p53 by okadaic acid, a tumor promoter.

1993 • 62 citations

An alternative theory of tissue specificity by tumor promotion of okadaic acid in glandular stomach of SD rats

1992 • 62 citations

Vimentin is hyperphosphorylated in primary human fibroblasts treated with okadaic acid

1991 • 61 citations

Effects of okadaic acid, an inhibitor of protein phosphatases-1 and -2A, on glucose transport and metabolism in skeletal muscle

1991 • 61 citations

Preparation of monoclonal antibodies against okadaic acid prepared from the sponge Halichondria okadai

1989 • 60 citations

Is the inhibition of protein phosphatase 1 and 2A activities a general mechanism of tumor promotion in human cancer development?

1992 • 56 citations

Codon 61 Mutations in the c‐Harvey‐ras Gene in Mouse Skin Tumors Induced by 7,12‐Dimethylbenz[a]anthracene Plus Okadaic Acid Class Tumor Promoters

1989 • 55 citations

Production of antibodies and development of a radioimmunoassay for okadaic acid

1988 • 55 citations

Mitotic arrest and enhanced nuclear protein phosphorylation in human leukemia K562 cells by okadaic acid, a potent protein phosphatase inhibitor and tumor promoter

1991 • 55 citations

The marine toxin okadaic acid is a potent neurotoxin for cultured cerebellar neurons

1991 • 53 citations

Vimentin, a cytoskeletal substrate of protein kinase C

1988 • 48 citations

Mechanisms of action of okadaic acid class tumor promoters on mouse skin.

1991 • 46 citations

Absolute Stereochemistry of the Calyculins, Potent Inhibitors of Protein Phosphatases 1 and 2A

1991 • 46 citations

Okadaic Acid and Phorbol Esters: Comparative Effects of These Tumor Promoters on Cell Transformation, Intercellular Communication and Differentiation in vitro

1990 • 46 citations

Protein phosphatase inhibitor okadaic acid enhances transmitter release at neuromuscular junctions.

1991 • 45 citations

Flat reversion by okadaic acid of raf and ret-II transformants.

1989 • 43 citations

The tumor promoters 12-O-tetradecanoylphorbol-13-acetate and okadaic acid differ in toxicity, mitogenic activity and induction of gene expression

1989 • 42 citations

Okadaic acid identifies a phosphorylation/dephosphorylation cycle controlling the inhibitory guanine-nucleotide-binding regulatory protein Gi2

1991 • 41 citations

Ca2+-Calmodulin-dependent protein kinase II phosphorylates various types of non-epithelial intermediate filament proteins

1990 • 41 citations

Okadaic acid induces the expression of both early and secondary response genes in mouse keratinocytes

1992 • 41 citations

Promotion of BALB/3T3 Cell Transformation by the Okadaic Acid Class of Tumor Promoters, Okadaic Acid and Dinophysistoxin‐1

1991 • 40 citations

Inhibition of protein phosphatases blocks myogenesis by first altering MyoD binding activity.

1992 • 38 citations

Dual regulation of intermediate filament phosphorylation.

1984 • 38 citations

Computer modelling of the 3-dimensional structures of the cyanobacterial hepatotoxins microcystin-LR and nodularin

1991 • 37 citations

Induction of morphological change of human myeloid leukemia and activation of protein kinase C by a novel antibiotic, tautomycin.

1988 • 37 citations

Effect of okadaic acid on phosphorylation-dephosphorylation of myosin light chain in aortic smooth muscle homogenate

1988 • 36 citations

Inhibition of myogenesis by okadaic acid, an inhibitor of protein phosphatases, 1 and 2A, correlates with the induction of AP1.

1992 • 36 citations

Specific labeling of mouse brain membrane phospholipids with [20-3H]phorbol 12-p-azidobenzoate 13-benzoate, a photolabile phorbol ester.

1983 • 36 citations

Development of an in vitro analogue of initiated mouse epidermis to study tumor promoters and antipromoters.

1990 • 36 citations

Induction of ornithine decarboxylase activity in mouse skin by a possible tumor promoter, okadaic acid.

1987 • 33 citations

Activity of diverse tumor promoters in a keratinocyte co-culture model of initiated epidermis

1992 • 32 citations

Okadaic acid and dinophysistoxin-1, non-TPA-type tumor promoters, stimulate prostaglandin E2 production in rat peritoneal macrophages

1989 • 29 citations

Okadaic acid-induced hyperphosphorylation of the epidermal growth factor receptor. Comparison with receptor phosphorylation and functions affected by another tumor promoter, 12-O-tetradecanoylphorbol-13-acetate.

1991 • 29 citations

The non-phorbol ester tumor promoter okadaic acid does not promote morphological transformation or inhibit junctional communication in hamster embryo cells

1990 • 28 citations

Apparent blue-green algae poisoning in swine subsequent to ingestion of a bloom dominated by Anabaena spiroides.

1983 • 27 citations

Rapid purification of protein phosphatase 2A from mouse brain by microcystin‐affinity chromatography

1991 • 27 citations

Diaplacental initiation of NMRI mice with 7, 12-dimethylbenz[a]anthracene during gestation days 6–20 and postnatal treatment of the F1-generation with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate: tumor incidence in organs other than the skin

1981 • 26 citations

Differentiation induction in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A

1992 • 26 citations

Okadaic Acid: A Reversible Inhibitor of Neoplastic Transformation of Mouse Fibroblasts

1990 • 25 citations

Permeaility of a non-TAP-type tumor promoter, okadaic acid, thirough lipid bilayer membrane

1990 • 22 citations

Morphological changes of human myeloid leukemia K562 cells by a protein phosphatase inhibitor, tautomycin.

1990 • 21 citations

Increased activity of the eEF-2 specific, Ca2+ and calmodulin dependent protein kinase III during the S-phase in ehrlich ascites cells

1991 • 19 citations

Photoaffinity labeling of protein phosphatase 2A, the receptor for a tumor promoter okadaic acid, by [27-3H]methyl 7- -(4-azidobenzoyl)okadaate

1990 • 19 citations

Phosphorylation of nuclear protein is an early event in TGFβ1 action

1991 • 17 citations

An alternative computer model of the 3-dimensional structural of microcystin-LR and nodularin rationalising their interactions with protein phosphatases 1 and 2A

1992 • 16 citations

Okadaic Acid Is a Potent Angiogenesis Inducer

1992 • 15 citations

Phospholipids involved in specific binding of 12-O-(5-azido-2-nitrobenzoyl)phorbol-13-acetate to epidermal microsomes, a photolabeling study

1985 • 13 citations

Differential activation and inhibition of lymphocyte proliferation by phorbol esters, mezerein, teleocidin, and okadaic acid.

1991 • 11 citations

The role of arginine in interactions of microcystins with protein phosphatases 1 and 2a

1992 • 9 citations

Cell transformation induced by bovine papillomavirus DNA as an assay for tumor promoters and chemopreventive agents.

1991 • 8 citations

Tumor promoting activity of teleocidin in skin and forestomach of mice initiated transplacentally with 7,12-dimethylbenz(a)anthracene

1987 • 7 citations

Binding competition of okadaic acid derivatives to anti-okadaic acid antibody

1991 • 3 citations

Hot Little Pond

1991 • 3 citations

Effects of okadaic acid on mouse hemopoietic cells

1989 • 2 citations

Royal Shorthand

1991 • 1 citations

Deleted Work

1955 • 0 citations