The Proamphiregulin Cytoplasmic Domain Is Required for Basolateral Sorting, but Is Not Essential for Constitutive or Stimulus-induced Processing in Polarized Madin-Darby Canine Kidney Cells

An Essential Role for Ectodomain Shedding in Mammalian Development

1998 • 1,607 citations

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

1999 • 1,484 citations

Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype

1995 • 1,457 citations

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

1995 • 1,035 citations

Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor

1995 • 1,016 citations

A metalloprotease-disintegrin, MDC9/meltrin-gamma /ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor

1998 • 523 citations

A Novel Clathrin Adaptor Complex Mediates Basolateral Targeting in Polarized Epithelial Cells

1999 • 509 citations

The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

1989 • 482 citations

Transmembrane TGF-α precursors activate EGF/TGF-α receptors

1989 • 432 citations

Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease

1991 • 413 citations

Diverse Cell Surface Protein Ectodomains Are Shed by a System Sensitive to Metalloprotease Inhibitors

1996 • 404 citations

Membrane traffic in polarized epithelial cells

2000 • 384 citations

A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts.

1993 • 383 citations

Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.

1990 • 375 citations

Matrix Metalloproteinase-3 Releases Active Heparin-binding EGF-like Growth Factor by Cleavage at a Specific Juxtamembrane Site

1997 • 329 citations

Ectodomain Shedding of Epidermal Growth Factor Receptor Ligands Is Required for Keratinocyte Migration in Cutaneous Wound Healing

2000 • 303 citations

The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor.

1995 • 298 citations

Employment of the Epidermal Growth Factor Receptor in Growth Factor–Independent Signaling Pathways

1999 • 271 citations

Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity.

1995 • 270 citations

LET-23 Receptor Localization by the Cell Junction Protein LIN-7 during C. elegans Vulval Induction

1996 • 268 citations

Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor

1999 • 262 citations

Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades

1999 • 248 citations

A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin.

1991 • 236 citations

Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype.

1997 • 214 citations

Calmodulin Regulates L-Selectin Adhesion Molecule Expression and Function through a Protease-Dependent Mechanism

1998 • 204 citations

The Shedding of Membrane-anchored Heparin-binding Epidermal-like Growth Factor Is Regulated by the Raf/Mitogen-activated Protein Kinase Cascade and by Cell Adhesion and Spreading

1999 • 185 citations

Heparin Blockade of Thrombin-Induced Smooth Muscle Cell Migration Involves Inhibition of Epidermal Growth Factor (EGF) Receptor Transactivation by Heparin-Binding EGF-Like Growth Factor

2000 • 183 citations

Transforming growth factor alpha: expression, regulation, and biological activities.

1995 • 166 citations

The Tetraspanin Cd9 Associates with Transmembrane TGF-α and Regulates TGF-α–Induced Egf Receptor Activation and Cell Proliferation

2000 • 162 citations

A Role for a PDZ Protein in the Early Secretory Pathway for the Targeting of proTGF-α to the Cell Surface

1999 • 151 citations

Autocrine Regulation of Keratinocytes: The Emerging Role of Heparin-Binding, Epidermal Growth Factor-Related Growth Factors

1998 • 141 citations

Multiple signals activate cleavage of the membrane transforming growth factor-alpha precursor.

1991 • 129 citations

The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGFα into soluble growth factor

1992 • 126 citations

Cell Surface Ectodomain Cleavage of Human Amphiregulin Precursor Is Sensitive to a Metalloprotease Inhibitor

1998 • 123 citations

Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin-binding EGF-like growth factor independently of protein kinase C

1998 • 119 citations

Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55

2000 • 114 citations

Contact-dependent Growth Inhibition and Apoptosis of Epidermal Growth Factor (EGF) Receptor-expressing Cells by the Membrane-anchored Form of Heparin-binding EGF-like Growth Factor

1999 • 100 citations

Basolateral targeting and efficient consumption of transforming growth factor-alpha when expressed in Madin-Darby canine kidney cells

1994 • 92 citations

Apical Enrichment of Human EGF Precursor in Madin-Darby Canine Kidney Cells Involves Preferential Basolateral Ectodomain Cleavage Sensitive to a Metalloprotease Inhibitor

1997 • 90 citations

Tyrosine Phosphorylation and Proteolysis

1998 • 87 citations

Association of the transmembrane TGF-alpha precursor with a protein kinase complex.

1994 • 83 citations

Biosynthesis and Processing by Phorbol Ester of the Cell Surface-Associated Precursor Form of Heparin-Binding EGF-like Growth Factor

1994 • 77 citations

Possible role of coexpression of CD9 with membrane-anchored heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growth

1997 • 77 citations

The carboxyl-terminal valine residues of proTGF alpha are required for its efficient maturation and intracellular routing.

1997 • 76 citations

Autocrine Regulation of Membrane Transforming Growth Factor-α Cleavage

1996 • 75 citations

Trafficking and Proteolytic Release of Epidermal Growth Factor Receptor Ligands Are Modulated by Their Membrane-anchoring Domains

2000 • 74 citations

The cytoplasmic carboxy-terminal amino acid determines the subcellular localization of proTGF-α and membrane type matrix metalloprotease (MT1-MMP)

1999 • 73 citations

Secretion of human meprin from intestinal epithelial cells depends on differential expression of the α and β subunits

1999 • 72 citations

Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis

1999 • 72 citations

Activated release of membrane-anchored TGF-alpha in the absence of cytosol

1993 • 67 citations

Release of the Neuregulin Functional Polypeptide Requires Its Cytoplasmic Tail

1998 • 61 citations

Stimulation of cleavage of membrane proteins by calmodulin inhibitors

2000 • 60 citations

Removal of the Membrane-anchoring Domain of Epidermal Growth Factor Leads to Intracrine Signaling and Disruption of Mammary Epithelial Cell Organization

1998 • 59 citations

Polarized trafficking of plasma membrane proteins: emerging roles for coats, SNAREs, GTPases and their link to the cytoskeleton

1998 • 58 citations

The Cytoplasmic Juxtamembrane Domain of the Epidermal Growth Factor Receptor Contains a Novel Autonomous Basolateral Sorting Determinant

1997 • 58 citations

The Heparin-Binding Domain of Amphiregulin Necessitates the Precursor Pro-Region for Growth Factor Secretion

1994 • 58 citations

Diphtheria toxin endocytosis and membrane translocation are dependent on the intact membrane-anchored receptor (HB-EGF precursor): studies on the cell-associated receptor cleaved by a metalloprotease in phorbol-ester-treated cells

1995 • 51 citations

Polarised Expression of Human Intestinal N‐benzoyl‐<scp>l</scp>‐tyroxyl‐p‐aminobenzoic Acid Hydrolase (Human Meprin) α and β Subunits in Madin‐Darby Canine Kidney Cells

1997 • 46 citations

Expression of the TGF alpha integral membrane precursor induces transformation of NRK cells.

1990 • 33 citations

Expression of Amphiregulin Is Regulated in Cultured Human Keratinocytes and in Developing Fetal Skin

1995 • 33 citations

A Differential Requirement for the COOH-terminal Region of the Epidermal Growth Factor (EGF) Receptor in Amphiregulin and EGF Mitogenic Signaling

1999 • 27 citations

The Release of Acetylcholine Receptor Inducing Activity (ARIA) from Its Transmembrane Precursor in Transfected Fibroblasts

1999 • 25 citations

Characterization of a novel amphiregulin-related molecule in 12-O-tetradecanoylphorbol-13-acetate-treated breast cancer cells

1996 • 20 citations

Mechanisms controlling the shedding of transmembrane molecules

1999 • 18 citations