Induction of Intestinal Inflammation in Mouse by Activation of Proteinase-Activated Receptor-2

Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker

1982 • 3,566 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism

2000 • 926 citations

Interactions of Mast Cell Tryptase with Thrombin Receptors and PAR-2

1997 • 592 citations

Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis

1999 • 587 citations

PAR3 is a cofactor for PAR4 activation by thrombin

2000 • 538 citations

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

1996 • 457 citations

Activation of Protease-Activated Receptor (PAR)-1, PAR-2, and PAR-4 Stimulates IL-6, IL-8, and Prostaglandin E2 Release from Human Respiratory Epithelial Cells

2002 • 391 citations

Protease-activated receptors in inflammation, neuronal signaling and pain

2001 • 373 citations

A protective role for protease-activated receptors in the airways

1999 • 366 citations

Molecular Cloning and Functional Expression of the Gene Encoding the Human Proteinase‐Activated Receptor 2

1995 • 334 citations

Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2

1997 • 319 citations

Interferon-γ decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin

1999 • 281 citations

Histamine and tryptase levels in patients with acute allergic reactions: An emergency department–based study

2000 • 264 citations

Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides

1997 • 240 citations

Release of mast cell mediators into the jejunum by cold pain stress in humans

1998 • 231 citations

Proteinase-Activated Receptor-2-Activating Peptides Induce Leukocyte Rolling, Adhesion, and Extravasation In Vivo

1999 • 224 citations

Characterization of the inflammatory response to proteinase‐activated receptor‐2 (PAR₂)‐activating peptides in the rat paw

1999 • 221 citations

Proteinases and proteinase-activated receptor 2: A possible role to promote visceral hyperalgesia in rats

2002 • 211 citations

Interleukin-8 Controls Bacterial Transepithelial Translocation at the Cost of Epithelial Destruction in Experimental Shigellosis

1999 • 211 citations

Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis

2001 • 197 citations

Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1.

1999 • 184 citations

The role of mast cell tryptase in regulating endothelial cell proliferation, cytokine release, and adhesion molecule expression: tryptase induces expression of mRNA for IL-1 beta and IL-8 and stimulates the selective release of IL-8 from human umbilical vein endothelial cells.

1998 • 174 citations

The Role of Mast Cell Tryptase in Regulating Endothelial Cell Proliferation, Cytokine Release, and Adhesion Molecule Expression: Tryptase Induces Expression of mRNA for IL-1β and IL-8 and Stimulates the Selective Release of IL-8 from Human Umbilical Vein Endothelial Cells

1998 • 144 citations

Release of Mast Cell Tryptase from Human Colorectal Mucosa in Inflammatory Bowel Disease

2001 • 140 citations

Review article: proteinase‐activated receptors — novel signals for gastrointestinal pathophysiology

2000 • 134 citations

Interleukin-6 Production by Endothelial Cells via Stimulation of Protease-Activated Receptors Is Amplified by Endotoxin and Tumor Necrosis Factor-α

2001 • 133 citations

Reversible Expression of Tryptases and Chymases in the Jejunal Mast Cells of Mice Infected with Trichinella spiralis

1998 • 112 citations

Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart

2000 • 111 citations

Evidence for the Presence of a Proteinase-Activated Receptor Distinct From the Thrombin Receptor in Vascular Endothelial Cells

1996 • 109 citations

Protease-Activated Receptor-2 Involvement in Hypotension in Normal and Endotoxemic Rats In Vivo

1999 • 106 citations

The Role of Up-Regulated Serine Proteases and Matrix Metalloproteinases in the Pathogenesis of a Murine Model of Colitis

2000 • 102 citations

Intestinal Epithelial Barrier Dysfunction in Crohn's Disease

1997 • 101 citations

[41] Nitric oxide as antiinflammatory agent

1996 • 100 citations

Protease-Activated G Protein-Coupled Receptors on Human Platelets and Endothelial Cells

1997 • 96 citations

Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open‐label pilot study

2002 • 85 citations

Role of cyclooxygenase-2 in gastric mucosal defense

2001 • 81 citations

Spontaneously developing chronic colitis in IL-10/iNOS double-deficient mice

2000 • 78 citations

Vascular Effects of Proteinase-Activated Receptor 2 Agonist Peptide

1997 • 75 citations

A Study of the Relationships Among Survival, Gut-Origin Sepsis, and Bacterial Translocation in a Model of Systemic Inflammation

1992 • 67 citations

Basolateral PAR‐2 receptors mediate KCl secretion and inhibition of Na⁺ absorption in the mouse distal colon

2002 • 62 citations

Colonic proteinases: increased activity in patients with ulcerative colitis.

1998 • 61 citations

Characterisation of immune mediator release during the immediate response to segmental mucosal challenge in the jejunum of patients with food allergy

1999 • 59 citations

Simultaneous quantitation of cytokine mRNAs in interleukin-1 beta stimulated U373 human astrocytoma cells by a polymerisation chain reaction method involving co-amplification with an internal multi-specific control.

1992 • 59 citations

Annexin 1 is Overexpressed and Specifically Secreted During Experimentally Induced Colitis in Rats

1995 • 58 citations

Quantification of cytokine gene expression by competitive PCR using a colorimetric assay.

1995 • 38 citations

Urocortin and Inflammation: Confounding Effects of Hypotension on Measures of Inflammation

1999 • 34 citations

Influence of inflammatory bowel disease on the distribution and concentration of pancreatic secretory trypsin inhibitor within the colon.

1995 • 31 citations

Protease-activated receptor-2 activation improves efficiency of experimental ischemic preconditioning

2002 • 30 citations

Vagally dependent protective action of calcitonin gene-related peptide on colitis

1999 • 27 citations

Basal secretion and anaphylactic release of rat mast cell protease-II (RMCP-II) from ex vivo perfused rat jejunum: translocation of RMCP-II into the gut lumen and its relation to mucosal histology.

1995 • 22 citations

Expression of clusterin in Crohn's disease of the terminal ileum.

2001 • 13 citations

Demonstration of Chymotryptic and Tryptic activities in Mast Cells of Rodents: Comparison of 17 Species of the Family Muridae

2001 • 9 citations