The Role of Up-Regulated Serine Proteases and Matrix Metalloproteinases in the Pathogenesis of a Murine Model of Colitis

Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

1996 • 1,227 citations

Proteolytic remodeling of extracellular matrix

1995 • 1,086 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease.

1991 • 491 citations

Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine

1990 • 489 citations

CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.

1993 • 471 citations

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system.

1990 • 449 citations

TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence

1990 • 444 citations

Cytokine regulation of metalloproteinase gene expression

1993 • 432 citations

Transforming growth factor beta (TGF-?) in inflammation: A cause and a cure

1992 • 417 citations

Matrilysin: An epithelial matrix metalloproteinase with potentially novel functions

1996 • 370 citations

Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils

1994 • 353 citations

A major role for matrix metalloproteinases in T cell injury in the gut.

1997 • 329 citations

Matrix metalloproteinase levels are elevated in inflammatory bowel disease

1999 • 321 citations

Microscopic localization of active proteases by in situ zymography: detection of matrix metalloproteinase activity in vascular tissue

1995 • 277 citations

Cytokine regulation of matrix metalloproteinase activity and its regulatory dysfunction in disease.

1995 • 273 citations

Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations.

1998 • 217 citations

Enhanced expression of matrilysin, collagenase, and stromelysin-1 in gastrointestinal ulcers.

1996 • 200 citations

Inflammatory bowel disease in C.B-17 scid mice reconstituted with the CD45RBhigh subset of CD4+ T cells.

1996 • 180 citations

Relative production of tumour necrosis factor alpha and interleukin 10 in adult respiratory distress syndrome

1997 • 140 citations

Distribution of the matrix metalloproteinases stromelysin, gelatinases A and B, and collagenase in Crohn's disease and normal intestine.

1994 • 138 citations

Prognostic value of markers of collagen remodeling in venous ulcers

1999 • 91 citations

Postsurgical wound progression monitored by temporal changes in the expression of matrix metalloproteinase-9

1997 • 87 citations

Protease activity in a hapten-induced model of ulcerative colitis in rats.

1997 • 70 citations

Faecal Elastase Reflects Disease Activity in Active Ulcerative Colitis

1992 • 63 citations

Membrane-Type Matrix Metalloproteinases and Cell Surface-Associated Activation Cascades for Matrix Metalloproteinases

1998 • 61 citations

Biomechanical and biochemical study of a standardized wound healing model

1997 • 59 citations

Divergent patterns of matrix metalloproteinase activity during wound healing in ileum and colon of rats.

1996 • 57 citations

Proteolytic degradation of intestinal mucosal extracellular matrix after lamina propria T cell activation.

1996 • 57 citations

Polyclonal expansion of adoptively transferred CD4⁺ αβ T cells in the colonic lamina propria of scid mice with colitis

1996 • 56 citations

Gut‐homing CD4⁺ T cell receptor αβ⁺ T cells in the pathogenesis of murine inflammatory bowel disease

1994 • 44 citations

Cytotoxic reactivity of gut lamina propria CD4⁺ αβ T cells in SCID mice with colitis

1996 • 43 citations

Comparison of Reflectance and Transmission Densitometry, Using Document and Laser Scanners, for Quantitation of Stained Western Blots

1996 • 37 citations

Transforming growth factor β (TGF β) in inflammation: a cause and a cure

1992 • 29 citations

The Drug 5-Aminosalicylic Acid Rescues α<sub>1</sub>-Proteinase Inhibitor from the Neutrophil Oxidative Inactivation

1992 • 12 citations

Tumour necrosis factor-alpha (TNF-α) transcription and translation in the CD4+ T cell-transplanted scid mouse model of colitis

1999 • 11 citations

Clarification of immunoblots on polyvinylidene difluoride (PVDF) membranes for transmission densitometry

1996 • 9 citations