Interferon-α and interferon-γ reduce excessive collagen synthesis and procollagen mRNA levels of scleroderma fibroblasts in culture

Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.

1982 • 1,333 citations

Biochemistry of Interferons and Their Actions

1982 • 868 citations

Interleukin 1, a potential regulator of fibroblast proliferation.

1982 • 835 citations

Modified procedure for the assay of H3- or C14-labeled hydroxyproline

1966 • 710 citations

Heritable Diseases of Collagen

1984 • 572 citations

Increased Collagen Synthesis by Scleroderma Skin Fibroblasts In Vitro A POSSIBLE DEFECT IN THE REGULATION OR ACTIVATION OF THE SCLERODERMA FIBROBLAST

1974 • 545 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Lymphocyte-Mediated Activation of Fibroblast Proliferation and Collagen Production

1978 • 358 citations

Cellular infiltrates in scleroderma skin

1977 • 356 citations

Selective inhibition of human diploid fibroblast collagen synthesis by interferons.

1984 • 336 citations

Lymphokine stimulation of collagen accumulation.

1976 • 322 citations

Localization of types I, II, and III collagen mRNAs in developing human skeletal tissues by in situ hybridization

1987 • 319 citations

Gamma interferon is the lymphokine and beta interferon the monokine responsible for inhibition of fibroblast collagen production and late but not early fibroblast proliferation.

1985 • 278 citations

Scleroderma

1979 • 241 citations

Gamma-interferon inhibits collagen synthesis in vivo in the mouse.

1987 • 181 citations

Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts

1986 • 173 citations

Mononuclear Cell-Conditioned Medium Containing Mononuclear Cell Factor (MCF), Homologous With Interleukin 1, Stimulates Collagen and Fibronectin Synthesis by Adherent Rheumatoid Synovial Cells: Effects of Prostaglandin E2 and Indomethacin

1985 • 165 citations

Synthesis and degradation of type I procollagen mRNAs in cultured human skin fibroblasts and the effect of cortisol.

1985 • 148 citations

Inhibition of collagen synthesis by mononuclear cell supernates.

1979 • 142 citations

Transcriptional control of human diploid fibroblast collagen synthesis by γ-interferon

1984 • 132 citations

Modulation of procollagen gene expression by retinoids. Inhibition of collagen production by retinoic acid accompanied by reduced type I procollagen messenger ribonucleic acid levels in human skin fibroblast cultures.

1985 • 123 citations

Interleukin-1 increases collagen production and mRNA levels in cultured skin fibroblasts

1987 • 117 citations

Inhibition of excessive scleroderma fibroblast collagen production by recombinant γ‐interferon: Association with a coordinate decrease in types I and III procollagen messenger RNA levels

1986 • 106 citations

Immune interferon inhibits collagen synthesis by rheumatoid synovial cells associated wth decreaded levels of the procollagen mRNAs(FEBS 2156)

1985 • 83 citations

Increased type I collagen mRNA levels in cultured scleroderma fibroblasts

1984 • 76 citations

Coordinated regulation of type I and type III collagen production and mRNA levels of pro ?1(I) and pro ?2(I) collagen in cultured morphea fibroblasts

1987 • 74 citations

Elevated proα2(I) collagen mRNA levels in cultured scleroderma fibroblasts result from an increased transcription rate of the corresponding gene

1987 • 57 citations

Collagen synthesis in generalized morphea

1983 • 21 citations

Collagen accumulation by dermal fibroblast cultures of patients with linear localized scleroderma.

1980 • 9 citations