Neural substrates of drug craving and relapse in drug addiction

The neural basis of drug craving: An incentive-sensitization theory of addiction

1993 • 7,074 citations

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

A psychomotor stimulant theory of addiction.

1987 • 2,704 citations

Drug Abuse: Hedonic Homeostatic Dysregulation

1997 • 2,472 citations

Drugs of abuse: anatomy, pharmacology and function of reward pathways

1992 • 2,091 citations

An opponent-process theory of motivation: I. Temporal dynamics of affect.

1974 • 1,644 citations

Opioids excite dopamine neurons by hyperpolarization of local interneurons

1992 • 1,585 citations

Neuropsychopharmacology

1990 • 1,545 citations

Molecular and Cellular Basis of Addiction

1997 • 1,324 citations

Responses of monkey dopamine neurons to reward and conditioned stimuli during successive steps of learning a delayed response task

1993 • 1,279 citations

Cannabinoid and Heroin Activation of Mesolimbic Dopamine Transmission by a Common µ ₁ Opioid Receptor Mechanism

1997 • 1,078 citations

Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants.

1984 • 1,060 citations

The dopamine hypothesis of the reinforcing properties of cocaine

1991 • 990 citations

Reinstatement of cocaine-reinforced responding in the rat

1981 • 936 citations

Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol.

1986 • 852 citations

Preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli

1996 • 826 citations

Adenosine–dopamine receptor–receptor interactions as an integrative mechanism in the basal ganglia

1997 • 804 citations

Cocaine Addiction: Psychology and Neurophysiology

1991 • 753 citations

Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats

1984 • 644 citations

Molecular Mechanisms of Drug Reinforcement and Addiction

1995 • 573 citations

Stress Preferentially Increases Extraneuronal Levels of Excitatory Amino Acids in the Prefrontal Cortex: Comparison to Hippocampus and Basal Ganglia

1993 • 565 citations

Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems

1982 • 560 citations

Neurobiology of opiate abuse

1992 • 546 citations

Intracranial self-administration of morphine into the ventral tegmental area in rats

1981 • 497 citations

An Opponent-Process Theory of Motivation

2008 • 470 citations

Conditioned responses to cocaine-related stimuli in cocaine abuse patients

1992 • 457 citations

Organization of amygdaloid projections to the prefrontal cortex and associated striatum in the rat

1991 • 456 citations

Modulation of Cocaine Self-Administration in the Rat Through D-3 Dopamine Receptors

1993 • 452 citations

The role of reward pathways in the development of drug dependence

1987 • 439 citations

The development of a cocaine craving questionnaire

1993 • 413 citations

Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period

1996 • 405 citations

Neuropharmacological Mechanisms of Drug Reward: Beyond Dopamine in the Nucleus Accumbens

1998 • 382 citations

Cocaine-induced cocaine craving

1989 • 381 citations

Self-injection of amphetamine directly into the brain

1983 • 373 citations

Adenosine-dopamine interactions in the brain

1992 • 366 citations

The Prefrontal Cortex Regulates the Basal Release of Dopamine in the Limbic Striatum: An Effect Mediated by Ventral Tegmental Area

1996 • 365 citations

Stress reinstates heroin-seeking in drug-free animals: An effect mimicking heroin, not withdrawal

1995 • 364 citations

Glucocorticoids have state-dependent stimulant effects on the mesencephalic dopaminergic transmission.

1996 • 339 citations

Lesions of the basolateral amygdala abolish the ability of drug associated cues to reinstate responding during withdrawal from self-administered cocaine

1997 • 338 citations

Δ9-Tetrahydrocannabinol produces naloxone-blockable enhancement of presynaptic basal dopamine efflux in nucleus accumbens of conscious, freely-moving rats as measured by intracerebral microdialysis

1990 • 331 citations

Involvement of cAMP-Dependent Protein Kinase in the Nucleus Accumbens in Cocaine Self-Administration and Relapse of Cocaine-Seeking Behavior

1998 • 325 citations

Corticotropin-Releasing Factor, But Not Corticosterone, Is Involved in Stress-Induced Relapse to Heroin-Seeking in Rats

1997 • 308 citations

Relapse to drug-seeking: neural and molecular mechanisms

1998 • 299 citations

Drug reinstatement of heroin-reinforced responding in the rat

1983 • 266 citations

Cortical Regulation of Subcortical Dopamine Release: Mediation via the Ventral Tegmental Area

1995 • 260 citations

Reinforcing effects of morphine in the nucleus accumbens

1982 • 254 citations

Cocaine-but not food-seeking behavior is reinstated by stress after extinction

1997 • 254 citations

Molecular Neurobiology of Dopaminergic Receptors

1993 • 251 citations

Comparison of the distributions of D1 and D2 dopamine receptor mRNAs in rat brain.

1991 • 246 citations

Self-administration of methionine enkephalin into the nucleus accumbens

1984 • 238 citations

Disruption of cocaine and heroin self-administration following kainic acid lesions of the nucleus accumbens

1985 • 232 citations

Relapse to heroin-seeking in rats under opioid maintenance: the effects of stress, heroin priming, and withdrawal

1996 • 220 citations

Morphine-dopamine interaction: Ventral tegmental morphine increases nucleus accumbens dopamine release

1991 • 218 citations

Organization of amygdaloid projections to brainstem dopaminergic, noradrenergic, and adrenergic cell groups in the rat

1992 • 217 citations

Effects of opioid and dopamine receptor antagonists on relapse induced by stress and re-exposure to heroin in rats

1996 • 198 citations

Place preference conditioning reveals the involvement of D1-dopamine receptors in the motivational properties of μ- and κ-opioid agonists

1987 • 189 citations

Bromocriptine self-administration and bromocriptine-reinstatement of cocaine-trained and heroin-trained lever pressing in rats

1990 • 179 citations

Glucocorticoids and behavioral effects of psychostimulants. II: cocaine intravenous self-administration and reinstatement depend on glucocorticoid levels.

1997 • 175 citations

Amygdalonigral pathway: An anterograde study in the rat with Phaseolus vulgaris leucoagglutinin (PHA‐L)

1990 • 174 citations

Behavioral effects of selective dopaminergic compounds in rats discriminating cocaine injections.

1991 • 173 citations

Habit-forming actions of nomifensine in nucleus accumbens

1995 • 170 citations

A learning model of addiction.

1992 • 159 citations

Dopamine D1 and D2 mediation of the discriminative stimulus properties ofd-amphetamine and cocaine

1991 • 156 citations

Dopamine receptor mRNA expression patterns by opioid peptide cells in the nucleus accumbens of the rat: A double in situ hybridization study

1995 • 150 citations

Reinstatement of heroin self-administration habits: morphine prompts and naltrexone discourages renewed responding after extinction

1992 • 141 citations

The D1 agonists SKF 82958 and SKF 77434 are self-administered by rats

1992 • 137 citations

Discriminative stimulus effects of cocaine in squirrel monkeys: involvement of dopamine receptor subtypes.

1991 • 133 citations

Conditioned increases in mesolimbic dopamine overflow by stimuli associated with cocaine

1993 • 131 citations

A comparison of the effects of intra-accumbens injections of amphetamine and morphine on reinstatement of heroin intravenous self-administration behavior

1988 • 114 citations

Involvement of the ventral tegmental dopamine system in opioid and psychomotor stimulant reinforcement.

1986 • 101 citations

Relationships among physiological and self-report responses produced by cocaine-related cues

1997 • 101 citations

Inactivation of Gi and G(o) proteins in nucleus accumbens reduces both cocaine and heroin reinforcement

1994 • 97 citations

Effects of cocaine alone and in combination with bromocriptine in human cocaine abusers.

1992 • 94 citations

Effects of dopamine agonists and antagonists on cocaine-induced operant responding for a cocaine-associated stimulus

1996 • 94 citations

Cocaine-induced conditioned locomotion: Absence of associated increases in dopamine release

1992 • 92 citations

Reinstatement of extinguished cocaine-taking behavior by cocaine and caffeine

1994 • 87 citations

Lack of an effect of 6-hydroxydopamine lesions of the nucleus accumbens on intravenous morphine self-administration

1988 • 78 citations

Psychotropic Drugs of Abuse

1991 • 62 citations

Electrophysiological responses of neurons of the ventral tegmental area to electrical stimulation of amygdala and lateral septum

1981 • 62 citations

Haloperidol prevents the reinstatement of amphetamine-rewarded runway responding in rats

1990 • 60 citations

Preferential occupation of mineralocorticoid receptors by corticosterone enhances glutamate-induced burst firing in rat midbrain dopaminergic neurons

1996 • 55 citations

The relation between dopamine oxidation currents in the nucleus accumbens and conditioned increases in motor activity in rats following repeated administration of d‐amphetamine or cocaine

1998 • 55 citations

Molecular Mechanisms of Cocaine Addiction

1996 • 55 citations

The Neurobiology of Cocaine‐Induced Reinforcement

2007 • 53 citations

Reinstatement of responding maintained by cocaine or thiamylal.

1984 • 46 citations

Cocaine Reward and Cocaine Craving: The Role of Dopamine in Perspective

1994 • 31 citations

The reinforcing and rate effects of intracranial dopamine administration.

1986 • 21 citations

Deleted Work

1955 • 0 citations