The dopamine hypothesis of the reinforcing properties of cocaine

Handbook of Chemical Neuroanatomy

1986 • 4,276 citations

Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine

1987 • 2,189 citations

Brain Dopamine and Reward

1989 • 1,899 citations

Neuropsychopharmacology

1990 • 1,545 citations

Cocaine and Other Stimulants

1988 • 982 citations

Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens

1980 • 736 citations

On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine

1977 • 733 citations

The pharmacology of cocaine related to its abuse.

1989 • 685 citations

Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats

1984 • 644 citations

New concepts in cocaine addiction: The dopamine depletion hypothesis

1985 • 608 citations

Citalopram — Pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity

1982 • 589 citations

Amphetamine, cocaine, phencyclidine and nomifensine increase extracellular dopamine concentrations preferentially in the nucleus accumbens of freely moving rats

1989 • 562 citations

Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems

1982 • 560 citations

Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens

1990 • 538 citations

Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine.

1977 • 490 citations

Chemical release of dopamine from striatal homogenates: evidence for an exchange diffusion model.

1979 • 436 citations

Cocaine and Other Stimulants

1977 • 421 citations

Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys.

1989 • 389 citations

Dopamine in the nucleus accumbens during cocaine self-administration as studied by in vivo microdialysis

1989 • 386 citations

Mapping cocaine binding sites in human and baboon brain in vivo

1989 • 300 citations

Concurrent and simultaneous use of alcohol with cocaine: results of national survey

1990 • 282 citations

The D1 dopamine receptor antagonist SCH 23390 increases cocaine self-administration in the rat

1987 • 281 citations

ASSOCIATION OF POSTOPERATIVE DELIRIUM WITH RAISED SERUM LEVELS OF ANTICHOLINERGIC DRUGS

1981 • 244 citations

Extracellular dopamine in rat striatum following uptake inhibition by cocaine, nomifensine and benztropine

1987 • 226 citations

Cocaine: An in vivo microdialysis evaluation of its acute action on dopamine transmission in rat striatum

1989 • 218 citations

Persistence of neurochemical changes in dopamine systems after repeated cocaine administration.

1990 • 217 citations

Mesocorticolimbic Dopamine Systems and Reward

1988 • 207 citations

Cocaine reinforcement and extracellular dopamine overflow in rat nucleus accumbens: an in vivo microdialysis study

1989 • 204 citations

Intravenous self-administration of dopamine receptor agonists by rhesus monkeys.

1984 • 203 citations

Antagonism of cocaine self-administration by selective dopamine D1 and D2 antagonists

1990 • 195 citations

The effects of chlorpromazine on psychomotor stimulant self-administration in the Rhesus monkey

1972 • 186 citations

Cocaine increases extracellular dopamine in rat nucleus accumbens and ventral tegmental area as shown by in vivo microdialysis

1989 • 183 citations

Bromocriptine self-administration and bromocriptine-reinstatement of cocaine-trained and heroin-trained lever pressing in rats

1990 • 179 citations

Effects of a D1 and a D2 dopamine antagonist on the self-administration of cocaine and piribedil by Rhesus monkeys

1986 • 177 citations

In Vivo Microdialysis as a Technique to Monitor Drug Transport: Correlation of Extracellular Cocaine Levels and Dopamine Overflow in the Rat Brain

1988 • 141 citations

Neuropharmacological assessment of cocaine self-administration into the medial prefrontal cortex

1986 • 136 citations

Outpatient Treatment of 'Crack' Cocaine Smoking With Flupenthixol Decanoate

1989 • 133 citations

Cocaine Abuse among Opioid Addicts: Demographic and Diagnostic Factors in Treatment

1986 • 131 citations

The effects of a D1 and a D2 dopamine antagonist on behavior maintained by cocaine or food

1989 • 131 citations

Methylphenidate Treatment of Cocaine Abusers without Attention Deficit Disorder: A Negative Report

1985 • 119 citations

Methylphenidate (Ritalin®) treatment of cocaine dependence—A preliminary report

1984 • 119 citations

Neuroleptic reduction of cocaine-induced paranoia but not euphoria?

1986 • 115 citations

Quantitative determination of the effects of catecholaminergic agonists and antagonists on the rewarding efficacy of brain stimulation

1987 • 113 citations

Extracellular cocaine and dopamine concentrations are linearly related in rat striatum

1988 • 106 citations

Effects of intravenous cocaine are partially attenuated by haloperidol

1989 • 101 citations

Reinforcing and subjective effects of several anorectics in normal human volunteers.

1987 • 100 citations

Reduction of the rewarding effect of brain stimulation by a blockade of dopamine D1 receptor with SCH 23390

1986 • 80 citations

Does amphetamine preferentially increase the extracellular concentration of dopamine in the mesolimbic system of freely moving rats?

1990 • 75 citations

Effects of continuous infusions of SCH 23390 on cocaine- or food-maintained behavior in rhesus monkeys

1990 • 70 citations

Cocaine Abuse and its Treatment

1984 • 64 citations

Cocaine receptors: In vivo labeling with ³H‐(—)cocaine, ³H‐win 35,065‐2, and ³H‐win 35,428

1989 • 60 citations

Effects of haloperidol and physostigmine on self-administration of local anesthetics

1982 • 54 citations

Evaluation of mixtures of morphine and d-amphetamine for subjective and physiological effects

1986 • 39 citations

GBR 12909 reverses the SCH 23390 inhibition of rewarding effects of brain stimulation

1990 • 18 citations