3′-Azidothymidine (Zidovudine) Inhibits Glycosylation and Dramatically Alters Glycosphingolipid Synthesis in Whole Cells at Clinically Relevant Concentrations

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

1986 • 1,348 citations

INHIBITORS OF THE BIOSYNTHESIS AND PROCESSING OF N-LINKED OLIGOSACCHARIDE CHAINS

1987 • 1,122 citations

Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.

1990 • 889 citations

endo-beta-N-acetylglucosaminidase F: endoglycosidase from Flavobacterium meningosepticum that cleaves both high-mannose and complex glycoproteins.

1982 • 689 citations

Ganglioside-mediated modulation of cell growth, growth factor binding, and receptor phosphorylation.

1984 • 501 citations

Induction of erythroid differentiation in the human leukaemia cell line K562

1979 • 470 citations

Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates.

1994 • 395 citations

Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors

1993 • 380 citations

Clinical Pharmacology of 3'-Azido-2',3'-Dideoxythymidine (Zidovudine) and Related Dideoxynucleosides

1989 • 356 citations

Gangliosides of human, bovine, and rabbit plasma

1972 • 354 citations

THE BIOCHEMISTRY OF AIDS

1991 • 332 citations

Purine and Pyrimidine Metabolism

1995 • 193 citations

The in vitro and in vivo anti-retrovirus activity, and intracellular metabolism of 3′-azido-2′,3′-dideoxythymidine and 2′,3′-dideoxycytidine are highly dependent on the cell species

1988 • 185 citations

A novel ganglioside, de-N-acetyl-GM3 (II3NeuNH2LacCer), acting as a strong promoter for epidermal growth factor receptor kinase and as a stimulator for cell growth.

1988 • 183 citations

Cellular pharmacology of 3'-azido-3'-deoxythymidine with evidence of incorporation into DNA of human bone marrow cells.

1989 • 130 citations

Uncoupling of ganglioside biosynthesis by Brefeldin A.

1990 • 124 citations

Acyclic Guanosine Analogs Inhibit DNA Polymerases .alpha., .delta., and .epsilon. with Very Different Potencies and Have Unique Mechanisms of Action

1995 • 122 citations

Selective action of 3'-azido-3'-deoxythymidine 5'-triphosphate on viral reverse transcriptases and human DNA polymerases.

1990 • 118 citations

Primary defect of congenital dyserythropoietic anemia type II. Failure in glycosylation of erythrocyte lactosaminoglycan proteins caused by lowered N-acetylglucosaminyltransferase II.

1987 • 105 citations

Biosynthesis of N‐Acetylneuraminic Acid in Morris Hepatomas

1973 • 77 citations

Two procedures to remove polar contaminants from a crude brain lipid extract by using prepacked reversed‐phase columns

1987 • 76 citations

A mutated transferrin receptor lacking asparagine-linked glycosylation sites shows reduced functionality and an association with binding immunoglobulin protein.

1991 • 66 citations

Interactions of azidothymidine triphosphate with the cellular DNA polymerases alpha, delta, and epsilon and with DNA primase.

1992 • 59 citations

[17] Labeling complex carbohydrates of animal cells with monosaccharides

1978 • 57 citations

3‘-Azido-3‘-deoxythymidine potently inhibits protein glycosylation. A novel mechanism for AZT cytotoxicity.

1994 • 49 citations

Nuclear DNA synthesis in vitro is mediated via stable replication forks assembled in a temporally specific fashion in vivo.

1988 • 40 citations

Inhibition of mammalian dna polymerase-associated 3′ to 5′ exonuclease activity by 5′-monophosphates of 3′-azido-3′-deoxythymidine and 3′-amino-3′-deoxythymidine

1993 • 36 citations

Carbohydrate antigen profiles of human erythroleukemia cell lines HEL and K562

1983 • 35 citations

Glycosphingolipids of K562 cells: A chemical and immunological analysis

1981 • 29 citations

Stereochemistry of the hydrogen transfer to the coenzyme by octopine dehydrogenase

1973 • 25 citations

A truncated epoxy-glucosylceramide uncouples glycosphingolipid biosynthesis by decreasing lactosylceramide synthase activity.

1994 • 22 citations

Biosynthesis of glycosphingolipids by human myeloid leukemia cells

1985 • 19 citations

Acquisition of the functional properties of the transferrin receptor during its biosynthesis

1991 • 16 citations

Simultaneous determination of sugar incorporation into glycosphingolipids and glycoproteins

1992 • 9 citations

Effects of 3′-Azido-3′-Deoxythymidine on the Deoxynucleoside Triphosphate Pools of Cultured Human Cells

1989 • 9 citations

Purine and Pyrimidine Metabolism in Man

1989 • 6 citations

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