Induction of multidrug resistance (MDR) by transfection of MCF‐10A cell line with c‐Ha‐ras and c‐erbB‐2 oncogenes

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Association of Multiple Copies of the N-mycOncogene with Rapid Progression of Neuroblastomas

1985 • 1,989 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Isolation and Characterization of a Spontaneously Immortalized Human Breast Epithelial Cell Line, MCF-10

1990 • 1,495 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

Multiple-Drug Resistance in Human Cancer

1987 • 703 citations

Isolation of amplified and overexpressed DNA sequences from adriamycin-resistant human breast cancer cells.

1987 • 296 citations

Monoclonal antibody JSB‐1 detects a highly conserved epitope on the P‐glycoprotein associated with multi‐drug‐resistance

1988 • 278 citations

Transformation of Human Breast Epithelial Cells by c‐Ha‐ras Oncogene

1991 • 162 citations

Increased resistance to cis-diamminedichloroplatinum(II) in NIH 3T3 cells transformed by ras oncogenes.

1988 • 156 citations

myc oncogenes: activation and amplification

1987 • 147 citations

Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals

1988 • 125 citations

Resistance to anticancer drugs in NIH3T3 cells transfected with c-myc and/or c-H-ras genes

1991 • 90 citations

Inverse correlation between expression of multidrug resistance gene and N-myc oncogene in human neuroblastomas.

1990 • 77 citations

Additive effects of c‐erbB‐2, c‐Ha‐ras, and transforming growth factor‐α genes on in vitro transformation of human mammary epithelial cells

1992 • 69 citations

Response to mitoxantrone in advanced breast cancer: correlation with expression of c-erbB-2 protein and glutathione S-transferases

1992 • 66 citations

Amplification and protein over-expression of the neu/HER-2/c-erbB-2 protooncogene in human breast carcinomas: relationship to loss of gene sequences on chromosome 17, family history and prognosis

1990 • 63 citations