Bcl-2: B Cell Life, Death and Neoplasia
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Abstract
References (13)
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
1990 • 3,817 citations
bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
1989 • 1,252 citations
Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18
1985 • 1,188 citations
The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining
1985 • 1,021 citations
Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.
1985 • 972 citations
Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.
1990 • 926 citations
The Natural History of Initially Untreated Low-Grade Non-Hodgkin's Lymphomas
1984 • 922 citations
Multiple Recurrent Genomic Defects in Follicular Lymphoma
1987 • 535 citations
Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.
1988 • 499 citations
Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells.
1987 • 297 citations
Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners.
1987 • 236 citations
Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population.
1990 • 223 citations
Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells.
1989 • 138 citations