A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

1987 • 3,683 citations

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

2004 • 2,021 citations

The neuropathology of schizophrenia

1999 • 1,664 citations

Disruption of two novel genes by a translocation co-segregating with schizophrenia

2000 • 1,250 citations

Schizophrenia as a Disorder of Neurodevelopment

2002 • 1,137 citations

Isolation of a Miller–Dicker lissencephaly gene containing G protein β-subunit-like repeats

1993 • 1,067 citations

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

2002 • 1,037 citations

Schizophrenia and Affective Disorders—Cosegregation with a Translocation at Chromosome 1q42 That Directly Disrupts Brain-Expressed Genes: Clinical and P300 Findings in a Family

2001 • 729 citations

Efficient in utero gene transfer system to the developing mouse brain using electroporation: visualization of neuronal migration in the developing cortex

2001 • 665 citations

Altered Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Cells in Frontal Lobe of Schizophrenics Implies Disturbances of Cortical Development

1993 • 660 citations

Schizophrenia: Diverse Approaches to a Complex Disease

2002 • 604 citations

Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality

1998 • 571 citations

Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization

1999 • 546 citations

RNAi reveals doublecortin is required for radial migration in rat neocortex

2003 • 530 citations

A LIS1/NUDEL/Cytoplasmic Dynein Heavy Chain Complex in the Developing and Adult Nervous System

2000 • 506 citations

NUDEL Is a Novel Cdk5 Substrate that Associates with LIS1 and Cytoplasmic Dynein

2000 • 482 citations

Disrupted in Schizophrenia 1 (DISC1): Association with Schizophrenia, Schizoaffective Disorder, and Bipolar Disorder

2004 • 437 citations

Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration

2004 • 415 citations

Disrupted-in-Schizophrenia-1 (DISC-1): Mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth

2002 • 387 citations

DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation

2003 • 374 citations

Nucleokinesis in Neuronal Migration

2005 • 347 citations

Ndel1 Operates in a Common Pathway with LIS1 and Cytoplasmic Dynein to Regulate Cortical Neuronal Positioning

2004 • 346 citations

Life is a journey: a genetic look at neocortical development

2002 • 339 citations

Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects

2003 • 325 citations

Glyceraldehyde-3-phosphate dehydrogenase: Nuclear translocation participates in neuronal and nonneuronal cell death

1997 • 325 citations

Chromosome 1 loci in Finnish schizophrenia families

2001 • 315 citations

Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth

2003 • 312 citations

New Directions in Neuronal Migration

2002 • 311 citations

Serine 732 Phosphorylation of FAK by Cdk5 Is Important for Microtubule Organization, Nuclear Movement, and Neuronal Migration

2003 • 301 citations

Par6α signaling controls glial-guided neuronal migration

2004 • 271 citations

The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport

1997 • 251 citations

Human Brain Malformations and Their Lessons for Neuronal Migration

2001 • 233 citations

Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders

2003 • 224 citations

Interaction of reelin signaling and Lis1 in brain development

2003 • 217 citations

Cytoplasmic Dynein and Dynactin Are Required for the Transport of Microtubules into the Axon

1998 • 217 citations

A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder

2005 • 215 citations

Role of Unc51.1 and its binding partners in CNS axon outgrowth

2004 • 194 citations

LIS1 and dynein motor function in neuronal migration and development

2001 • 169 citations

Disruption of hippocampal development in vivo by CR-50 mAb against Reelin

1997 • 169 citations

Yeast two-hybrid screens implicate DISC1 in brain development and function

2003 • 160 citations

CORTICAL NEURONAL MIGRATION MUTANTS SUGGEST SEPARATE BUT INTERSECTING PATHWAYS

2004 • 134 citations

Coupling PAF Signaling to Dynein Regulation

2004 • 115 citations

DISC1 localizes to the centrosome by binding to kendrin

2004 • 106 citations

Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1

2005 • 72 citations