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Chemokines

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Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

2001 • 1,922 citations

Lineage relationship and protective immunity of memory CD8 T cell subsets

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Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

1998 • 1,687 citations

Absence of Monocyte Chemoattractant Protein-1 Reduces Atherosclerosis in Low Density Lipoprotein Receptor–Deficient Mice

1998 • 1,569 citations

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

1998 • 1,535 citations

Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

2003 • 1,527 citations

T-Cell Function and Migration — Two Sides of the Same Coin

2000 • 1,437 citations

Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

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Chemokines and disease

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MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions

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Lymphocyte traffic control by chemokines

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A chemokine-driven positive feedback loop organizes lymphoid follicles

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Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

2000 • 1,209 citations

Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function

2000 • 1,188 citations

Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node

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A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen

1996 • 1,125 citations

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.

1997 • 1,078 citations

Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells

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Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization

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α4 integrins mediate lymphocyte attachment and rolling under physiologic flow

1995 • 1,018 citations

Chemokines and the Arrest of Lymphocytes Rolling Under Flow Conditions

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A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes

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Regulation of Dendritic Cell Migration to the Draining Lymph Node

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The Plasticity of Dendritic Cell Responses to Pathogens and Their Components

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Matrilysin Shedding of Syndecan-1 Regulates Chemokine Mobilization and Transepithelial Efflux of Neutrophils in Acute Lung Injury

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Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells

1997 • 731 citations

The chemokine system: redundancy for robust outputs

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The integrin VLA-4 supports tethering and rolling in flow on VCAM-1.

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Chemokines as regulators of T cell differentiation

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An Alternatively Spliced Variant of CXCR3 Mediates the Inhibition of Endothelial Cell Growth Induced by IP-10, Mig, and I-TAC, and Acts as Functional Receptor for Platelet Factor 4

2003 • 693 citations

Distinct patterns and kinetics of chemokine production regulate dendritic cell function

1999 • 692 citations

Chemokines and the Tissue-Specific Migration of Lymphocytes

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The Chemokine Receptor CXCR4 Is Required for the Retention of B Lineage and Granulocytic Precursors within the Bone Marrow Microenvironment

1999 • 691 citations

Divergent Signals and Cytoskeletal Assemblies Regulate Self-Organizing Polarity in Neutrophils

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Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils.

1992 • 683 citations

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2000 • 643 citations

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The α-Chemokine, Stromal Cell-derived Factor-1α, Binds to the Transmembrane G-protein-coupled CXCR-4 Receptor and Activates Multiple Signal Transduction Pathways

1998 • 627 citations

Dancing to the tune of chemokines

2001 • 624 citations

Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes

2003 • 599 citations

Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense

1999 • 568 citations

Glycosaminoglycans Interact Selectively with Chemokines and Modulate Receptor Binding and Cellular Responses

1999 • 564 citations

Lymph-Borne Chemokines and Other Low Molecular Weight Molecules Reach High Endothelial Venules via Specialized Conduits While a Functional Barrier Limits Access to the Lymphocyte Microenvironments in Lymph Node Cortex

2000 • 562 citations

Multiple Roles of Antimicrobial Defensins, Cathelicidins, and Eosinophil-Derived Neurotoxin in Host Defense

2004 • 557 citations

Viral mimicry of cytokines, chemokines and their receptors

2003 • 547 citations

High endothelial venules (HEVs): specialized endothelium for lymphocyte migration

1995 • 539 citations

A Role for Cdc42 in Macrophage Chemotaxis

1998 • 537 citations

Inflammatory Chemokine Transport and Presentation in HEV

2001 • 532 citations

Multistep Navigation and the Combinatorial Control of Leukocyte Chemotaxis

1997 • 531 citations

A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice.

1998 • 525 citations

A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity

2002 • 522 citations

Chemokines Trigger Immediate β2 Integrin Affinity and Mobility Changes

2000 • 517 citations

Migratory Properties of Naive, Effector, and Memory Cd8+ T Cells

2001 • 514 citations

Haptotaxis and the Mechanism of Cell Motility

1967 • 509 citations

Chemokine Requirements for B Cell Entry to Lymph Nodes and Peyer's Patches

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RhoA is required for monocyte tail retraction during transendothelial migration

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Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins

1996 • 494 citations

Rapid Acquisition of Tissue-specific Homing Phenotypes by CD4+ T Cells Activated in Cutaneous or Mucosal Lymphoid Tissues

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Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy

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Endothelial cell binding of NAP-1/IL-8: role in neutrophil emigration

1992 • 477 citations

Decreased Atherosclerotic Lesion Formation in CX3CR1/Apolipoprotein E Double Knockout Mice

2003 • 465 citations

RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

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P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-Regulated Guanine-Nucleotide Exchange Factor for Rac

2002 • 460 citations

The Leukotriene C4 Transporter MRP1 Regulates CCL19 (MIP-3β, ELC)–Dependent Mobilization of Dendritic Cells to Lymph Nodes

2000 • 456 citations

Rab GTPases coordinate endocytosis

2000 • 447 citations

Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8.

1993 • 444 citations

Chemokine receptor homo- or heterodimerization activates distinct signaling pathways

2001 • 423 citations

The Cc Chemokine Thymus-Derived Chemotactic Agent 4 (Tca-4, Secondary Lymphoid Tissue Chemokine, 6ckine, Exodus-2) Triggers Lymphocyte Function–Associated Antigen 1–Mediated Arrest of Rolling T Lymphocytes in Peripheral Lymph Node High Endothelial Venules

2000 • 420 citations

Differential CC chemokine-induced enhancement of T helper cell cytokine production.

1997 • 417 citations

Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes

1993 • 412 citations

Antigen Presentation in Extracellular Matrix

2000 • 409 citations

Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes

2001 • 407 citations

The molecular basis of T helper 1 and T helper 2 cell differentiation

2000 • 400 citations

Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines

2001 • 398 citations

Chemokine Signaling and Functional Responses: The Role of Receptor Dimerization and TK Pathway Activation

2001 • 381 citations

Directional Sensing Requires Gβγ-Mediated PAK1 and PIXα-Dependent Activation of Cdc42

2003 • 380 citations

The Ccr7 Ligand ELC (Ccl19) Is Transcytosed in High Endothelial Venules and Mediates T Cell Recruitment

2001 • 367 citations

Essential Role of Phosphoinositide 3-Kinase δ in Neutrophil Directional Movement

2003 • 364 citations

Molecular Bases of Odor Discrimination: Reconstitution of Olfactory Receptors that Recognize Overlapping Sets of Odorants

2001 • 364 citations

Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow

2003 • 362 citations

The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9

2000 • 358 citations

Differential binding of chemokines to glycosaminoglycan subpopulations

1994 • 351 citations

Chemokine/Chemokine Receptor Nomenclature

2002 • 348 citations

International Union of Pharmacology. XXX. Update on Chemokine Receptor Nomenclature

2002 • 346 citations

CCR7 Expression and Memory T Cell Diversity in Humans

2001 • 342 citations

Rapid leukocyte integrin activation by chemokines

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β-Chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans

1998 • 334 citations

Viral exploitation and subversion of the immune system through chemokine mimicry

2001 • 334 citations

CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells

2003 • 328 citations

Ligand-selective receptor conformations revisited: the promise and the problem

2003 • 319 citations

Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1 −2518 G/G genotype in CAD patients

2001 • 314 citations

Intestinal dendritic cells increase T cell expression of α4β7 integrin

2002 • 309 citations

The Ligands of CXC Chemokine Receptor 3, I-TAC, Mig, and IP10, Are Natural Antagonists for CCR3

2001 • 307 citations

RhoA and ROCK Promote Migration by Limiting Membrane Protrusions

2003 • 304 citations

The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor.

1995 • 299 citations

Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice

2002 • 298 citations

The Role of Chemokines in the Microenvironmental Control of T versus B Cell Arrest in Peyer's Patch High Endothelial Venules

2000 • 298 citations

From Malaria to Chemokine Receptor: The Emerging Physiologic Role of the Duffy Blood Group Antigen

1997 • 296 citations

Priming of Memory But Not Effector CD8 T Cells by a Killed Bacterial Vaccine

2001 • 294 citations

Active movement of T cells away from a chemokine

2000 • 293 citations

Spatial control of actin polymerization during neutrophil chemotaxis

1999 • 281 citations

Lymphoid Chemokine B Cell-Attracting Chemokine-1 (CXCL13) Is Expressed in Germinal Center of Ectopic Lymphoid Follicles Within the Synovium of Chronic Arthritis Patients

2001 • 277 citations

Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

2002 • 276 citations

Receptors induce chemotaxis by releasing the βγ subunit of G _i , not by activating G _q or G _s

1997 • 276 citations

Chemoattractant Receptor Cross-desensitization

1999 • 275 citations

Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans

2003 • 267 citations

The β-Chemokine Receptor D6 Is Expressed by Lymphatic Endothelium and a Subset of Vascular Tumors

2001 • 264 citations

The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium

2001 • 263 citations

Cell polarity: an examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxis.

1981 • 263 citations

Intravascular IL-8. Inhibitor of polymorphonuclear leukocyte accumulation at sites of acute inflammation.

1991 • 262 citations

Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1

2003 • 260 citations

Uncoupling of inflammatory chemokine receptors by IL-10: generation of functional decoys

2000 • 259 citations

Inhibitory and Stimulatory Regulation of Rac and Cell Motility by the G_12/13-Rho and G_i Pathways Integrated Downstream of a Single G Protein-Coupled Sphingosine-1-Phosphate Receptor Isoform

2003 • 259 citations

Specialized roles of the chemokine receptors CCR1 and CCR5 in the recruitment of monocytes and TH1-like/CD45RO+T cells

2001 • 253 citations

CCR5 Binds Multiple CC-Chemokines: MCP-3 Acts as a Natural Antagonist

1999 • 252 citations

The BBXB Motif of RANTES Is the Principal Site for Heparin Binding and Controls Receptor Selectivity

2001 • 250 citations

Activation of RhoA and ROCK Are Essential for Detachment of Migrating Leukocytes

2001 • 250 citations

Structural diversity of heparan sulfate binding domains in chemokines

2002 • 249 citations

Overlapping Roles of CXCL13, Interleukin 7 Receptor α, and CCR7 Ligands in Lymph Node Development

2003 • 244 citations

CCL28 Has Dual Roles in Mucosal Immunity as a Chemokine with Broad-Spectrum Antimicrobial Activity

2003 • 241 citations

CCR5 Binds Multiple CC-Chemokines: MCP-3 Acts as a Natural Antagonist

1999 • 239 citations

A chemokine-to-cytokine-to-chemokine cascade critical in antiviral defense

2000 • 238 citations

Neutrophil elastase up‐regulates interleukin‐8 via toll‐like receptor 4

2003 • 236 citations

The role of chemokines in the regulation of dendritic cell trafficking

1999 • 229 citations

Cloning and Characterization of a Novel Promiscuous Human β-Chemokine Receptor D6

1997 • 229 citations

Monoclonal antibodies detect different distribution patterns of IL-8 receptor A and IL-8 receptor B on human peripheral blood leukocytes.

1994 • 222 citations

Integrating Conflicting Chemotactic Signals

1999 • 220 citations

Polarization of Chemokine Receptors to the Leading Edge during Lymphocyte Chemotaxis

1997 • 219 citations

Cellular signaling in macrophage migration and chemotaxis

2000 • 216 citations

Neutrophil attractant/activation protein‐1 (interleukin‐8) induces in vitro neutrophil migration by haptotactic mechanism

1993 • 215 citations

Endothelial Cell “Memory” of Inflammatory Stimulation: Human Venular Endothelial Cells Store Interleukin 8 in Weibel-Palade Bodies

1998 • 215 citations

Chemokines, chemokine receptors and small-molecule antagonists: recent developments

2002 • 212 citations

Dendritic cell migration to lymph nodes: cytokines, chemokines, and lipid mediators

2001 • 210 citations

Up-regulation of CCR1 and CCR3 and induction of chemotaxis to CC chemokines by IFN-gamma in human neutrophils.

1999 • 207 citations

Receptor-mediated Regulation of PI3Ks Confines PI(3,4,5)P₃to the Leading Edge of Chemotaxing Cells

2003 • 205 citations

Differential immobilization and hierarchical involvement of chemokines in monocyte arrest and transmigration on inflamed endothelium in shear flow

1999 • 202 citations

Receptor-dependent RhoA Activation in G12/G13-deficient Cells

2003 • 195 citations

Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC)

2000 • 195 citations

Helper T cells regulate type-2 innate immunity in vivo

2002 • 195 citations

The interaction between Cdc42 and WASP is required for SDF-1–induced T-lymphocyte chemotaxis

2001 • 193 citations

Lymphoid Tissue Homing Chemokines Are Expressed in Chronic Inflammation

2000 • 193 citations

Selective G Protein Coupling by C-C Chemokine Receptors

1996 • 191 citations

Naive T Cell Recruitment to Nonlymphoid Tissues: A Role for Endothelium-Expressed CC Chemokine Ligand 21 in Autoimmune Disease and Lymphoid Neogenesis

2003 • 190 citations

G Protein-Coupled Chemokine Receptors Induce Both Survival and Apoptotic Signaling Pathways

2002 • 189 citations

Chemokines in lymphopoiesis and lymphoid organ development

2001 • 187 citations

Cutting Edge: Scavenging of Inflammatory CC Chemokines by the Promiscuous Putatively Silent Chemokine Receptor D6

2003 • 187 citations

Up-Regulation of CCR1 and CCR3 and Induction of Chemotaxis to CC Chemokines by IFN-γ in Human Neutrophils

1999 • 184 citations

Compartmentalized Production of CCL17 In Vivo

2003 • 181 citations

Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5

2001 • 180 citations

Heterotrimeric G Protein Signaling: Roles in Immune Function and Fine-Tuning by RGS Proteins

1998 • 178 citations

Migration and Function of Antigen-Primed Nonpolarized T Lymphocytes in Vivo

2001 • 176 citations

Tumor Necrosis Factor–dependent Segmental Control of MIG Expression by High Endothelial Venules in Inflamed Lymph Nodes Regulates Monocyte Recruitment

2001 • 176 citations

Chemokines and dendritic cell traffic.

2000 • 171 citations

Spatial and Temporal Analysis of Rac Activation during Live Neutrophil Chemotaxis

2002 • 167 citations

Platelet‐derived CXC chemokines: old players in new games

2000 • 165 citations

Chemoattractants Induce a Rapid and Transient Upregulation of Monocyte α4 Integrin Affinity for Vascular Cell Adhesion Molecule 1 Which Mediates Arrest

2001 • 162 citations

Hepatic Expression of Secondary Lymphoid Chemokine (CCL21) Promotes the Development of Portal-Associated Lymphoid Tissue in Chronic Inflammatory Liver Disease

2002 • 161 citations

Travellers in many guises: The origins and destinations of dendritic cells

2002 • 161 citations

Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2

1998 • 160 citations

Chemotaxis in a lymphocyte cell line transfected with C-C chemokine receptor 2B: Evidence that directed migration is mediated by βγ dimers released by activation of G_αi-coupled receptors

1997 • 158 citations

Duffy Antigen Facilitates Movement of Chemokine Across the Endothelium In Vitro and Promotes Neutrophil Transmigration In Vitro and In Vivo

2003 • 151 citations

Platelet chemokines and their receptors: what is their relevance to platelet storage and transfusion practice?

2001 • 151 citations

Chemokines in autoimmune disease

2001 • 149 citations

Chemokine signalling: pivoting around multiple phosphoinositide 3‐kinases

2002 • 148 citations

Preferential Accumulation of Antigen-specific Effector CD4 T Cells at an Antigen Injection Site Involves CD62E-dependent Migration but Not Local Proliferation

2003 • 148 citations

A pertussis toxin‐sensitive process controls thymocyte emigration

1991 • 147 citations

Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice.

1998 • 145 citations

Th1/Th2 subsets: distinct differences in homing and chemokine receptor expression?

1999 • 145 citations

Acquisition of Selectin Binding and Peripheral Homing Properties by CD4+ and CD8+ T Cells

1999 • 143 citations

In vitro inhibitory effect of IL-8 and other chemoattractants on neutrophil-endothelial adhesive interactions.

1992 • 141 citations

New therapeutics that modulate chemokine networks

2002 • 141 citations

Chemokines Have Diverse Abilities to Form Solid Phase Gradients

2001 • 140 citations

Pertussis Toxin-sensitive Activation of Phospholipase C by the C5a and fMet-Leu-Phe Receptors

1996 • 139 citations

Genetic defect in T lymphocyte‐specific homing into peripheral lymph nodes

1997 • 138 citations

Plasminogen Activator Inhibitor-1 Supports IL-8-Mediated Neutrophil Transendothelial Migration by Inhibition of the Constitutive Shedding of Endothelial IL-8/Heparan Sulfate/Syndecan-1 Complexes

2003 • 135 citations

Examination of the Function of RANTES, MIP-1α, and MIP-1β following Interaction with Heparin-like Glycosaminoglycans

2000 • 135 citations

PI 3-Kinases and PTEN

2002 • 134 citations

Induction of Functional IL-8 Receptors by IL-4 and IL-13 in Human Monocytes

2000 • 132 citations

RGS13 Regulates Germinal Center B Lymphocytes Responsiveness to CXC Chemokine Ligand (CXCL)12 and CXCL13

2002 • 130 citations

Different Affinities of Glycosaminoglycan Oligosaccharides for Monomeric and Dimeric Interleukin-8: A Model for Chemokine Regulation at Inflammatory Sites

2002 • 130 citations

β-Arrestins Regulate Interleukin-8-induced CXCR1 Internalization

1999 • 129 citations

Molecular evolution of CXC chemokines: extant CXC chemokines originate from the CNS

2003 • 127 citations

Regulation of Chemotactic and Proadhesive Responses to Chemoattractant Receptors by RGS (Regulator of G-protein Signaling) Family Members

1998 • 125 citations

The ligand paradox between affinity and efficacy: can you be there and not make a difference?

2002 • 124 citations

[Ca2+]i Changes and Respiratory Burst in Human Neutrophils and Monocytes Induced by NAP-1/Interleukin-8, NAP-2, and gro/MGSA

1991 • 123 citations

Differential regulation of CXCR2 trafficking by Rab GTPases

2003 • 121 citations

Analysis of individual leucocyte behavior during chemotaxis

1972 • 119 citations

Modulating chemokines: more lessons from viruses

2000 • 119 citations

CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11

2003 • 118 citations

RANTES (CCL5) uses the proteoglycan CD44 as an auxiliary receptor to mediate cellular activation signals and HIV-1 enhancement

2003 • 118 citations

Regulator of G Protein Signaling 1 (RGS1) Markedly Impairs Giα Signaling Responses of B Lymphocytes

2000 • 118 citations

C-C Chemokine Receptor 3 Antagonism by the β-Chemokine Macrophage Inflammatory Protein 4, a Property Strongly Enhanced by an Amino-Terminal Alanine-Methionine Swap

2000 • 117 citations

A role of the Duffy antigen for the maintenance of plasma chemokine concentrations

2003 • 115 citations

Chemokine receptor dimerization: two are better than one

2001 • 115 citations

Human skin mast cells rapidly release preformed and newly generated TNF‐α and IL‐8 following stimulation with anti‐IgE and other secretagogues

2001 • 114 citations

Identification of a Motif in the Carboxyl Terminus of CXCR2 That Is Involved in Adaptin 2 Binding and Receptor Internalization

2000 • 113 citations

A Mechanism for the Impaired IFN-γ Production in C-C Chemokine Receptor 2 (CCR2) Knockout Mice: Role of CCR2 in Linking the Innate and Adaptive Immune Responses

2000 • 109 citations

Expression of CCR9 β-chemokine receptor is modulated in thymocyte differentiation and is selectively maintained in CD8+ T cells from secondary lymphoid organs

2001 • 109 citations

Identification of a Glycosaminoglycan-binding Site in Chemokine Macrophage Inflammatory Protein-1α

1997 • 108 citations

The strict regulation of lymphocyte migration to splenic white pulp does not involve common homing receptors

2002 • 108 citations

Eotaxin-3 is a natural antagonist for CCR2 and exerts a repulsive effect on human monocytes

2003 • 107 citations

Targeting CLA/E-selectin interactions prevents CCR4-mediated recruitment of human Th2 memory cells to human skin in vivo

2002 • 106 citations

Deletion of the Murine Duffy Gene (Dfy) Reveals that the Duffy Receptor Is Functionally Redundant

2000 • 105 citations

Thymocyte emigration is mediated by active movement away from stroma-derived factors

2002 • 104 citations

Chemokines on the move: control by the chemokine “interceptors” Duffy blood group antigen and D6

2003 • 102 citations

Novel chemokine functions in lymphocyte migration through vascular endothelium under shear flow

2001 • 100 citations

β-Arrestin Binding to CC Chemokine Receptor 5 Requires Multiple C-terminal Receptor Phosphorylation Sites and Involves a Conserved Asp-Arg-Tyr Sequence Motif

2002 • 100 citations

Shear-dependent Eosinophil Transmigration on Interleukin 4–stimulated Endothelial Cells

2001 • 98 citations

The Role of CD26&amp;sol;DPP IV in Chemokine Processing

1999 • 95 citations

In Situ Analysis Reveals Physical Interactions Between CD11b+ Dendritic Cells and Antigen-Specific CD4 T Cells After Subcutaneous Injection of Antigen

2002 • 92 citations

Quantitative Differences in Chemokine Receptor Engagement Generate Diversity in Integrin-Dependent Lymphocyte Adhesion

2002 • 92 citations

Molecular Machinations: Chemokine Signals in Host-Pathogen Interactions

2001 • 90 citations

Role of Regulator of G Protein Signaling 16 in Inflammation- Induced T Lymphocyte Migration and Activation

2003 • 83 citations

Physiological secretion of chemokines in human breast milk.

1998 • 80 citations

Chemokine-induced monocyte transmigration requires cdc42-mediated cytoskeletal changes

1998 • 78 citations

Combinatorial Model of Chemokine Involvement in Glomerular Monocyte Recruitment: Role of CXC Chemokine Receptor 2 in Infiltration During Nephrotoxic Nephritis

2001 • 74 citations

Transient Lung-Specific Expression of the Chemokine KC Improves Outcome in Invasive Aspergillosis

2002 • 74 citations

Binding of RANTES, MCP-1, MCP-3, and MIP-1alpha to cells in human skin.

1998 • 72 citations

Chemokine receptor antagonism as an approach to anti-inflammatory therapy: ‘just right’ or plain wrong?

2002 • 66 citations

The E. Donnall Thomas Lecture, 1993. The machinery of blood cell movements

1994 • 65 citations

Chemokine Expression Patterns Differ within Anatomically Distinct Regions of the Genital Tract duringChlamydia trachomatisInfection

2002 • 65 citations

Knock out models to dissect chemokine receptor function in vivo

2003 • 63 citations

Optimal Chemotactic Responses of Leukemic T Cells to Stromal Cell-Derived Factor-1 Requires the Activation of Both Class IA and IB Phosphoinositide 3-Kinases

2003 • 60 citations

GCP-2–induced internalization of IL-8 receptors: hierarchical relationships between GCP-2 and other ELR+-CXC chemokines and mechanisms regulating CXCR2 internalization and recycling

2000 • 60 citations

Differential coupling of CC chemokine receptors to multiple heterotrimeric G proteins in human interleukin-2-activated natural killer cells

1996 • 59 citations

Endothelial inflammation: the role of differential expression of N-deacetylase/N-sulphotransferase enzymes in alteration of the immunological properties of heparan sulphate

2003 • 58 citations

Monocyte haptotaxis induced by the RANTES chemokine

1993 • 49 citations

Normal human sweat contains interleukin-8

1995 • 48 citations

Interaction of the CC-Chemokine RANTES with Glycosaminoglycans Activates a p44/p42 Mitogen-Activated Protein Kinase-Dependent Signaling Pathway and Enhances Human Immunodeficiency Virus Type 1 Infectivity

2002 • 48 citations

Cell Surface Heparan Sulfate Participates in CXCL1-Induced Signaling

2003 • 43 citations

Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans

2003 • 42 citations

CXCR2 STIMULATION PRIMES CXCR1 [Ca2+]i RESPONSES TO IL-8 IN HUMAN NEUTROPHILS

1999 • 41 citations

CCR3 Expression Induced by IL-2 and IL-4 Functioning as a Death Receptor for B Cells

2003 • 39 citations

The Chemokine ESkine/CCL27 Displays Novel Modes of Intracrine and Paracrine Function

2002 • 37 citations

Expression and Production of the CXC Chemokine Growth-Related Oncogene-α by Human Eosinophils

2003 • 32 citations

Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes

2001 • 31 citations

CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells

2003 • 28 citations

The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium

2001 • 24 citations

CCL27/PESKY: a novel paradigm for chemokine function

2003 • 23 citations

Chondroitin sulfate A released from platelets blocks RANTES presentation on cell surfaces and RANTES-dependent firm adhesion of leukocytes

2002 • 23 citations

The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9

2000 • 19 citations

Identification and Characterization of Specific Receptor for Interleukin‐8 from the Surface of Human Monocytes

1996 • 14 citations

Th1/Th2 subsets: distinct differences in homing and chemokine receptor expression?

1999 • 12 citations

Differential immobilization and hierarchical involvement of chemokines in monocyte arrest and transmigration on inflamed endothelium in shear flow

1999 • 12 citations

Thymocyte emigration is mediated by active movement away from stroma-derived factors

2002 • 11 citations

The E. Donnall Thomas Lecture

2005 • 7 citations

Chondroitin sulfate A released from platelets blocks RANTES presentation on cell surfaces and RANTES-dependent firm adhesion of leukocytes

2002 • 3 citations

Pivotal role of TARC, a CC chemokine, in bacteriainduced fulminant hepatic failure in mice

2000 • 2 citations