Regulation of Cdc42-mediated morphological effects: a novel function for p53

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

1999 • 1,452 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Integrin-Mediated Activation of Cdc42 Controls Cell Polarity in Migrating Astrocytes through PKCζ

2001 • 1,004 citations

Database of p53 gene somatic mutations in human tumors and cell lines.

1994 • 866 citations

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

1997 • 802 citations

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

The p53 Network

1998 • 731 citations

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

1986 • 725 citations

Activation of Rac and Cdc42 by Integrins Mediates Cell Spreading

1998 • 638 citations

Signaling to p53

1998 • 636 citations

CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae.

1990 • 605 citations

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice.

1993 • 471 citations

Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott–Aldrich syndrome

1996 • 397 citations

Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility

1995 • 374 citations

Rho family proteins and Ras transformation: the RHOad less traveled gets congested

1998 • 352 citations

Cdc42 Regulates Anchorage-Independent Growth and Is Necessary for Ras Transformation

1997 • 312 citations

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

1994 • 231 citations

p53; from inductive signal to cellular effect

1997 • 214 citations

RhoG GTPase Controls a Pathway That Independently Activates Rac1 and Cdc42Hs

1998 • 162 citations

Cytokinesis arrest and redistribution of actin-cytoskeleton regulatory components in cells expressing the Rho GTPase CDC42Hs

1996 • 141 citations

Ezrin has properties to self-associate at the plasma membrane

1994 • 133 citations

Rho and Rac exert antagonistic functions on spreading of macrophage-derived multinucleated cells and are not required for actin fiber formation

2000 • 113 citations

Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappa B activation

1997 • 113 citations

The small GTPases Cdc42Hs, Rac1 and RhoG delineate Raf-independent pathways that cooperate to transform NIH3T3 cells

1997 • 107 citations

Rho is a negative regulator of human monocyte spreading.

1996 • 90 citations

The fixation, dehydration, drying and coating of cultured cells for SEM

1981 • 82 citations

Disruption of dynamic cell surface architecture of NIH3T3 fibroblasts by the N-terminal domains of moesin and ezrin: In vivo imaging with GFP fusion proteins

1999 • 70 citations

Human smooth muscle α-actin gene is a transcriptional target of the p53 tumor suppressor protein

1998 • 70 citations

Differential Effect of Rac and Cdc42 on p38 Kinase Activity and Cell Cycle Progression of Nonadherent Primary Mouse Fibroblasts

2000 • 63 citations

Down-regulation of actin genes precedes microfilament network disruption and actin cleavage during p53-mediated apoptosis

1997 • 58 citations

Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation

1998 • 54 citations

Filopodial Initiation and a Novel Filament-organizing Center, the Focal Ring

2001 • 52 citations

Spreading of differentiating human monocytes is associated with a major increase in membrane-bound CDC42.

1994 • 46 citations

Wild-type p53 protein shows calcium-dependent binding to F-actin

1999 • 41 citations

Changes in p53 expression can modify cell shape of ras-transformed fibroblasts and epitheliocytes

1997 • 35 citations

Targets for Transcriptional Activation by Wild-type p53: Endogenous Retroviral LTR, Immunoglobulin-like Promoter, and an Internal Promoter of the mdm2 Gene

1994 • 8 citations