Nitric Oxide:Biochemistry, Pathophysiology, and Detection

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Endothelium‐derived relaxing and contracting factors

1989 • 2,017 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Inhaled Nitric Oxide for the Adult Respiratory Distress Syndrome

1993 • 1,811 citations

Carbon Monoxide: a Putative Neural Messenger

1993 • 1,519 citations

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

1992 • 1,237 citations

Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.

1991 • 1,161 citations

Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor

1992 • 1,063 citations

Nitric Oxide as a Mediator of Relaxation of the Corpus Cavernosum in Response to Nonadrenergic, Noncholinergic Neurotransmission

1992 • 1,028 citations

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

1992 • 980 citations

Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans

1991 • 960 citations

Measurement of nitric oxide in biological models

1993 • 925 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.

1992 • 822 citations

Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine

1991 • 813 citations

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

1992 • 748 citations

Biological Roles of Nitric Oxide

1992 • 731 citations

Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn

1992 • 731 citations

Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases.

1992 • 728 citations

Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes.

1993 • 671 citations

Calmodulin is a subunit of nitric oxide synthase from macrophages.

1992 • 640 citations

Nitric Oxide Measured by a Porphyrinic Micro Sensor in Rat Brain after Transient Middle Cerebral Artery Occlusion

1993 • 632 citations

Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide.

1993 • 623 citations

Nitric oxide synthase is a cytochrome P-450 type hemoprotein

1992 • 617 citations

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

1992 • 616 citations

Protective and pathological roles of nitric oxide in endotoxin shock

1992 • 594 citations

Nitric oxide synthase in macula densa regulates glomerular capillary pressure.

1992 • 531 citations

Molecular cloning and characterization of human endothelial nitric oxide synthase

1992 • 494 citations

A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle.

1991 • 442 citations

An electrochemical microprobe for detecting nitric oxide release in brain tissue

1990 • 398 citations

Nitric oxide synthase activities in human myocardium

1993 • 358 citations

Inhibition of Cytochromes P450 by Nitric Oxide and a Nitric Oxide-Releasing Agent

1993 • 358 citations

Nitric Oxide Synthase Activity in Infantile Hypertrophic Pyloric Stenosis

1992 • 353 citations

Activation of a Cytosolic ADP-ribosyltransferase by Nitric Oxide-generating Agents

1989 • 349 citations

Quantitative and kinetic characterization of nitric oxide and EDRF released from cultured endothelial cells

1988 • 342 citations

Generation of nitric oxide by human neutrophils

1989 • 298 citations

Expression of nitric oxide synthase in kidney macula densa cells

1992 • 296 citations

Nitric oxide mediates iron release from ferritin

1990 • 290 citations

Nitric oxide as a signal in blood vessels

1992 • 285 citations

Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization.

1993 • 275 citations

<scp>l</scp>-arginine transport is increased in macrophages generating nitric oxide

1992 • 235 citations

Inhibition of Long-Term Potentiation by NMDA-Mediated Nitric Oxide Release

1992 • 233 citations

Advanced glycosylation endproducts block the antiproliferative effect of nitric oxide. Role in the vascular and renal complications of diabetes mellitus.

1992 • 215 citations

Nitric oxide, a biological effector

1991 • 203 citations

Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell <scp>l</scp>‐arginine transporter

1992 • 172 citations

Brain nitric oxide synthase is a haemoprotein

1992 • 151 citations

Differential distribution of nitric oxide synthase between cell fractions isolated from the rat gastric mucosa

1992 • 140 citations

Flow cytometric analysis of nitric oxide production in human neutrophils using dichlorofluorescein diacetate in the presence of a calmodulin inhibitor

1992 • 134 citations

Nitric oxide mediates tumor necrosis factor-α cytotoxicity in endothelial cells

1992 • 127 citations

Measurements of nitric oxide in biological materials using a porphyrinic microsensor

1993 • 116 citations

Phosphorylation of nitric oxide synthase by protein kinase A

1991 • 114 citations

Guanylyl Cyclase-Linked Receptors

1992 • 106 citations

Characterization of Conductive Polymeric Nickel(II) Tetrakis(3‐methoxy‐4‐hydroxy‐phenyl)Porphyrin as an Anodic Material for Electrocatalysis

1991 • 103 citations

A simple and sensitive bioassay method for detection of EDRF with RFL-6 rat lung fibroblasts

1991 • 94 citations

Oxidation of nitric oxide by oxygen in biological systems monitored by porphyrinic sensor

1992 • 93 citations

Sustained Hypertension in the Rat Induced by Chronic Blockade of Nitric Oxide Production

1992 • 86 citations

Protective effects of inhibitors of nitric oxide synthase in immune complex‐induced vasculitis

1992 • 82 citations

Localization of brain nitric oxide synthase (NOS) to human chromosome 12

1992 • 77 citations

Inhibition of Interleukin-1- -Induced Nitric Oxide Synthase in Vascular Smooth Muscle and Full Reversal of Interleukin-1- -Induced Hypotension by N -Amino-L-arginine

1992 • 76 citations

Relationship between nitroglycerin-induced vascular relaxation and nitric oxide production

1993 • 73 citations

Endothelium-derived relaxing factor released from canine femoral artery by acetylcholine cannot be identified as free nitric oxide by electron paramagnetic resonance spectroscopy.

1990 • 71 citations

NG-monomethyl-l-arginine causes nitric oxide synthesis in isolated arterial rings: Trouble in paradise

1992 • 66 citations

Polyclonal antibody against an inducible form of nitric oxide synthase purified from the liver of rats treated with Propionibacterium acnes and lipopolysaccharide

1992 • 58 citations

Bovine bronchial epithelial cells metabolize L-arginine to L-citrulline: Possible role of nitric oxide synthase

1993 • 55 citations

Identification of inducible calmodulin-dependent nitric oxide synthase in the liver of rats.

1992 • 53 citations

Effect of vasodilators, including nitric oxide, on the release of cGMP and cAMP in the isolated perfused rat kidney

1992 • 53 citations

Enhanced pneumonia resolution by inhalation of nitric oxide?

1993 • 51 citations

Histochemical demonstration of NADPH-diaphorase activity, a marker for nitric oxide synthase, in neurons of the rat pancreas

1992 • 49 citations

Nitric oxide hemoglobin in patients receiving nitroglycerin as detected by electron paramagnetic resonance spectroscopy.

1992 • 46 citations

Nitric oxide preferentially stimulates auto‐ADP‐ribosylation of glyceraldehyde‐3‐phosphate dehydrogenase compared to alcohol or lactate dehydrogenase

1993 • 36 citations

Clinical relevance of endothelium‐derived relaxing factor (EDRF).

1992 • 32 citations

Endothelial vasomotor regulation in health and disease

1992 • 22 citations

Direct measurement of nitric oxide in headspace gas produced by a chicken macrophage cell line in a closed culture system

1992 • 20 citations

Removal of Ammonia Interference in the Redox Chemiluminescence Assay of Nitric Oxide

1992 • 9 citations

Thin films of semiconducting polymeric porphyrins

1993 • 4 citations