Hinge and Amino-Terminal Sequences Contribute to Solution Dimerization of Human Progesterone Receptor

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Glutathione S-Transferases

1974 • 17,321 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.

1990 • 1,510 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

Differential Recognition of Target Genes by Nuclear Receptor Monomers, Dimers, and Heterodimers*

1994 • 789 citations

Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.

1993 • 749 citations

Steroid Hormone Receptors: Interaction with Deoxyribonucleic Acid and Transcription Factors*

1993 • 724 citations

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor

1990 • 617 citations

Solution structure of the DMA-binding domain of the oestrogen receptor

1990 • 458 citations

Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor

1994 • 402 citations

Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation.

1992 • 363 citations

Rapid purification of homodimer and heterodimer HIV‐1 reverse transcriptase by metal chelate affinity chromatography

1990 • 333 citations

Mechanisms of nuclear localization of the progesterone receptor: Evidence for interaction between monomers

1989 • 329 citations

Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors.

1992 • 314 citations

Physical interaction between heat shock proteins DnaK, DnaJ, and GrpE and the bacterial heat shock transcription factor σ32

1992 • 314 citations

Evidence for an Anti-parallel Orientation of the Ligand-activated Human Androgen Receptor Dimer

1995 • 277 citations

Steroid requirement for androgen receptor dimerization and DNA binding. Modulation by intramolecular interactions between the NH2-terminal and steroid-binding domains.

1993 • 215 citations

Ligand-dependent, transcriptionally productive association of the amino- and carboxyl-terminal regions of a steroid hormone nuclear receptor.

1995 • 209 citations

The DNA-Bending Protein HMG-1 Enhances Progesterone Receptor Binding to Its Target DNA Sequences

1994 • 200 citations

Binding of heat shock proteins to the avian progesterone receptor.

1989 • 192 citations

Evidence that the 90-kDa heat shock protein (HSP90) exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with Mr of 63,000, 56,000, and 50,000.

1991 • 177 citations

Localization of the 90-kDa heat shock protein-binding site within the hormone-binding domain of the glucocorticoid receptor by peptide competition

1991 • 165 citations

Immunologic analysis of human breast cancer progesterone receptors. 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodies

1987 • 162 citations

The Purified Activated Glucocorticoid Receptor is a Homodimer

1989 • 156 citations

Human Progesterone Receptor Complexed with the Antagonist RU 486 Binds to Hormone Response Elements in a Structurally Altered Form

1989 • 138 citations

Dimerization of mammalian progesterone receptors occurs in the absence of DNA and is related to the release of the 90-kDa heat shock protein.

1991 • 133 citations

Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90

1993 • 130 citations

Human estrogen receptor forms multiple protein-DNA complexes.

1990 • 126 citations

Homodimer formation is rate-limiting for high affinity DNA binding by glucocorticoid receptor.

1992 • 120 citations

Characterization and Functional Properties of the A and B Forms of Human Progesterone Receptors Synthesized in a Baculovirus System

1991 • 105 citations

The Nonconserved Hinge Region and Distinct Amino-Terminal Domains of the RORα Orphan Nuclear Receptor Isoforms are Required for Proper DNA Bending and RORα-DNA Interactions

1995 • 92 citations

Protein-protein contacts in the glucocorticoid receptor homodimer influence its DNA binding properties.

1990 • 88 citations

Ligands induce conformational changes in the carboxyl-terminus of progesterone receptors which are detected by a site-directed antipeptide monoclonal antibody.

1992 • 81 citations

Glucocorticosteroid Receptor Dimerization Investigated by Analysis of Receptor Binding to Glucocorticosteroid Responsive Elements Using a Monomer−Dimer Equilibrium Model

1996 • 61 citations

Assembly of a glucocorticoid receptor complex prior to DNA binding enhances its specific interaction with a glucocorticoid response element

1991 • 58 citations

An antiestrogen: a phosphotyrosyl peptide that blocks dimerization of the human estrogen receptor.

1995 • 55 citations

Effects of the steroid antagonist RU486 on dimerization of the human progesterone receptor

1992 • 52 citations

Characterization of the Domain Structure of Chick c-erbA by Deletion Mutation:in VitroTranslation and Cell Transfection Studies

1989 • 52 citations

Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells.

1992 • 51 citations

Analysis of androgen receptor-DNA interactions with receptor proteins produced in insect cells

1994 • 49 citations

Dimerization of the Chicken Progesterone Receptorin VitroCan Occur in the Absence of Hormone and DNA

1990 • 44 citations

Determinants of high-affinity DNA binding by the glucocorticoid receptor: evaluation of receptor domains outside the DNA-binding domain

1992 • 44 citations

Characterization of the Calf Uterine Progesterone Receptor and Its Stabilization by Nucleic Acids*

1984 • 44 citations

Dimerization characteristics of the DNA- and steroid-binding domains of the androgen receptor

1994 • 41 citations

The steroid-binding properties of recombinant glucocorticoid receptor: A putative role for heat shock protein hsp90

1990 • 35 citations

Modular Structure of Glucocorticoid Receptor Domains Is Not Equivalent to Functional Independence

1996 • 34 citations

The human estrogen receptor hormone binding domain dimerizes independently of ligand activation

1994 • 34 citations

Protein-protein interactions between the DNA-binding domains of nuclear receptors: Influence on DNA-binding

1993 • 32 citations

Differences in the binding mechanism of RU486 and progesterone to the progesterone receptor

1991 • 32 citations

Structure refinement of the glucocorticoid receptor-DNA binding domain from NMR data by relaxation matrix calculations

1995 • 31 citations

Differential DNA binding by calf uterine estrogen and progesterone receptors results from differences in oligomeric states

1991 • 30 citations

Molecular characterization by mass spectrometry of the human estrogen receptor ligand-binding domain expressed in Escherichia coli.

1995 • 28 citations

Structural Determinants of the Ligand-Binding Site of the Human Retinoic Acid Receptor .alpha.

1995 • 27 citations

Protein-Protein Interaction Studies Using Immobilized Oligohistidine Fusion Proteins

1993 • 25 citations

Binding of [3H]progesterone to the human progesterone receptor: differences between individual and mixed isoforms.

1996 • 25 citations

The side chains responsible for the dimerization of the estradiol receptor by ionic bonds are lost in a 17 kDa fragment extending downstream from aa 303

1994 • 14 citations

Specific binding of progesterone receptor to progesterone‐responsive elements does not require prior dimerization

1993 • 14 citations

Putative steroid binding domain of the human mineralocorticoid receptor, expressed in E. coli in the presence of heat shock proteins shows typical native receptor characteristics

1996 • 14 citations

Modulation of DNA‐binding specificity within the nuclear receptor family by substitutions at a single amino acid position

1995 • 13 citations

Biochemical characterization and novel isolation of pure estrogen receptor hormone-binding domain

1996 • 6 citations