Human Progesterone Receptor Complexed with the Antagonist RU 486 Binds to Hormone Response Elements in a Structurally Altered Form

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RU 38486: Potent antiglucocorticoid activity correlated with strong binding to the cytosolic glucocorticoid receptor followed by an impaired activation

1984 • 372 citations

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1989 • 270 citations

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1988 • 186 citations

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1986 • 185 citations

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1986 • 184 citations

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1987 • 179 citations

Receptors bound to antiprogestin form abortive complexes with hormone responsive elements

1988 • 164 citations

RU 38486: An Original Multifaceted Antihormone in Vivo

1984 • 163 citations

Immunologic analysis of human breast cancer progesterone receptors. 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodies

1987 • 162 citations

Steroid hormone antagonists at the receptor level: A role for the heat‐shock protein MW 90,000 (hsp 90)

1987 • 143 citations

DNA binding properties of glucocorticosteroid receptors bound to the steroid antagonist RU-486.

1984 • 137 citations

Inhibition of glucocorticosteroid action in cultured L-929 mouse fibroblasts by RU 486, a new anti-glucocorticosteroid of high affinity for the glucocorticosteroid receptor

1983 • 125 citations

Steroid Hormone-Dependent Interaction of Human Progesterone Receptor with its Target Enhancer Element

1988 • 92 citations

Binding of hormone accelerates the kinetics of glucocorticoid and progesterone receptor binding to DNA.

1989 • 84 citations

A Quantitative Comparison of Dual Control of a Hormone Response Element by Progestins and Glucocorticoids in the Same Cell Line

1989 • 80 citations

Human Progesterone Receptor Binding to Mouse Mammary Tumor Virus Deoxyribonucleic Acid: Dependence on Hormone and Nonreceptor Nuclear Factor(s)

1989 • 73 citations

Human Progesterone Receptor Transformation and Nuclear Down-Regulation are Independent of Phosphorylation

1988 • 73 citations

Mechanism of action of an antiprogesterone, RU486, in the rabbit endometrium

1985 • 64 citations

Transformation of calf uterine progesterone receptor: analysis of the process when receptor is bound to progesterone and RU38486

1987 • 51 citations

Glucocorticoid receptors bound to the antagonist RU486 are not downregulated despite their capacity to interact in vitro with defined gene regions

1987 • 47 citations

Immunocytochemical localization of progesterone receptors in breast cancer with anti-human receptor monoclonal antibodies.

1988 • 45 citations

In vitro activation and dna binding affinity of human lymphoid (cem-c7) cytoplasmic receptors labeled with the antiglucocorticoid ru 38486

1986 • 38 citations

Antiprogestin-receptor complexes: Differences in the interaction of the antiprogestin RU38,486 and the progestin R5020 with the progesterone receptor of human breast cancer cells

1986 • 31 citations

The antiprogesterone RU486 stabilizes the heterooligomeric, non-DNA-binding, 8S-form of the rabbit uterus cytosol progesterone receptor

1989 • 29 citations

Activation of rat liver glucocorticoid receptor bound to the antiglucocorticoid Ru38486

1985 • 27 citations

Stimulation of specific transcription and DNA binding studies suggest that in vitro transformed RU 486-glucocorticosteroid receptor complexes display agonist activity

1988 • 20 citations