Induction of heat shock (stress) genes in the mammalian brain by hyperthermia and other traumatic events: A current perspective

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

Cell Damage in the Brain: A Speculative Synthesis

1981 • 1,827 citations

Speculations on the functions of the major heat shock and glucose-regulated proteins

1986 • 1,574 citations

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1988 • 1,504 citations

The induction of gene activity in drosophila by heat shock

1979 • 1,308 citations

70K heat shock related proteins stimulate protein translocation into microsomes

1988 • 1,276 citations

Proteins as molecular chaperones

1987 • 910 citations

The Heat Shock Respons

1985 • 809 citations

Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly

1989 • 763 citations

Heat Shock Is Lethal to Fibroblasts Microinjected with Antibodies Against hsp70

1988 • 635 citations

Uncoating ATPase is a member of the 70 kilodalton family of stress proteins

1986 • 607 citations

Stress protein systems of mammalian cells

1986 • 564 citations

RNA splicing is interrupted by heat shock and is rescued by heat shock protein synthesis

1986 • 524 citations

Cellular and biochemical events in mammalian cells during and after recovery from physiological stress.

1986 • 513 citations

Protein Sorting to Mitochondria: Evolutionary Conservations of Folding and Assembly

1990 • 494 citations

Stress proteins, infection, and immune surveillance

1989 • 477 citations

Localization of 70-kDa stress protein induction in gerbil brain after ischemia

1988 • 465 citations

Structure and expression of the human gene encoding major heat shock protein HSP70.

1985 • 461 citations

Stress Proteins and Immunology

1990 • 458 citations

An enzyme that removes clathrin coats: purification of an uncoating ATPase.

1984 • 449 citations

Hyperthermia Protects Against Light Damage in the Rat Retina

1988 • 445 citations

Heat shock proteins: the search for functions.

1986 • 395 citations

Selective release from cultured mammalian cells of heat‐shock (stress) proteins that resemble glia‐axon transfer proteins

1989 • 389 citations

Purification of the major mammalian heat shock proteins.

1982 • 369 citations

Competitive Inhibition of hsp70 Gene Expression Causes Thermosensitivity

1988 • 319 citations

Heat shock proteins as markers of neural injury

1989 • 304 citations

The 70-kd mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles.

1985 • 301 citations

Coming in from the cold

1988 • 285 citations

Synthesis of a Stress Protein Following Transient Ischemia in the Gerbil

1985 • 270 citations

Morphological changes in the neuritic growth cone and target neuron during synaptic junction development in culture.

1976 • 267 citations

Complex regulation of heat shock- and glucose-responsive genes in human cells.

1988 • 242 citations

Enzymatic recycling of clathrin from coated vesicles

1986 • 237 citations

Trauma-Induced Protein in Rat Tissues: A Physiological Role for a "Heat Shock" Protein?

1981 • 233 citations

Heat shock-like protein is transferred from glia to axon

1986 • 229 citations

Heat Shock RNA Levels in Brain and Other Tissues After Hyperthermia and Transient Ischemia

1990 • 199 citations

Induction of a heat shock gene at the site of tissue injury in the rat brain

1989 • 183 citations

Induction of stress protein HSP70 in nerve cells after status epilepticus in the rat

1989 • 179 citations

Heat shock and the sorting of luminal ER proteins.

1989 • 178 citations

Evidence for the participation of actin microfilaments and bristle coats in the internalization of gap junction membrane.

1979 • 175 citations

In Situ Hybridization in Brain

1986 • 173 citations

Molecular and Cellular Effects of Heat-shock and Related Treatments of Mammalian Tissue-culture Cells

1982 • 154 citations

Coated vesicles and synaptogenesis. A developmental study in the cerebellar cortex of the rat

1971 • 151 citations

Selective induction of a heat shock gene in fibre tracts and cerebellar neurons of the rabbit brain detected by in situ hybridization

1987 • 145 citations

70‐Kilodalton Heat Shock Protein Induction in Cerebellar Astrocytes and Cerebellar Granule Cells In Vitro: Comparison with Immunocytochemical Localization After Hyperthermia In Vivo

1990 • 140 citations

Hypoxia—ischemia induces heat shock protein-like (HSP72) immunoreactivity in neonatal rat brain

1990 • 139 citations

The role of stress proteins in membrane biogenesis

1988 • 133 citations

Neural Plasticity: A Lifespan Approach

1988 • 131 citations

Synthesis of Heat Shock Proteins in Rat Brain Cortex after Transient Ischemia

1986 • 129 citations

Heat shock and thermotolerance during early rat embryo development

1987 • 126 citations

Selective Gene Expression in Focal Cerebral Ischemia

1986 • 123 citations

Stress proteins, arthritis, and autoimmunity

1989 • 113 citations

Dissociation of clathrin from coated vesicles by the uncoating ATPase.

1990 • 109 citations

Members of the 70-Kilodalton Heat Shock Protein Family Contain a Highly Conserved Calmodulin-Binding Domain

1990 • 108 citations

Translation of Unspliced Transcripts After Heat Shock

1988 • 105 citations

Stress-induced proteins

1988 • 100 citations

Protein Synthesis in Postischemic Rat Brain: A Two-Dimensional Electrophoretic Analysis

1986 • 99 citations

Heat shock protein in mammalian brain and other organs after a physiologically relevant increase in body temperature induced by D-lysergic acid diethylamide.

1983 • 98 citations

Early stages of synaptogenesis in the cervical spinal cord of the chick embryo

1973 • 95 citations

Synthesis of the major inducible heat shock protein in rat hippocampus after neonatal hypoxia-ischemia

1989 • 92 citations

Expression of heat shock genes (hsp70) in the mammalian brain: Distinguishing constitutively expressed and hyperthermia‐inducible mRNA species

1990 • 81 citations

The relationship of the rat brain 68 kDa microtubule-associated protein with synaptosomal plasma membranes and with the Drosophila 70 kDa heat-shock protein

1984 • 71 citations

Members of the 70-kilodalton heat shock protein family contain a highly conserved calmodulin-binding domain.

1990 • 66 citations

Essential roles of 70kDa heat inducible proteins

1989 • 64 citations

Stereotaxic injection of kainic acid into the striatum of rats induces synthesis of mRNA for heat shock protein 70

1988 • 63 citations

Spinal cord injury and the stress protein response

1989 • 62 citations

Inherited and Environmentally Induced Retinal Degenerations

1990 • 60 citations

The induction of the major heat‐stress protein in purified rat glial cells

1988 • 58 citations

Axonal transport of a heat shock protein in the rabbit visual system.

1985 • 57 citations

Hyperthermia Induces the Synthesis of a Heat Shock Protein by Polysomes Isolated from the Fetal and Neonatal Mammalian Brain

1983 • 56 citations

Regulation of the inducible heat shock 71 genes in early neural development of cultured rat embryos

1989 • 53 citations

Axonal Polypeptides Cross‐Reactive with Antibodies to Neurofilament Proteins

1983 • 52 citations

Axonal transport of a clathrin uncoating atpase (HSC70): A role for hsc70 in the modulation of coated vesicle assembly in vivo

1989 • 52 citations

Effects of Amphetamine on Protein Synthesis and Energy Metabolism in Mouse Brain: Role of Drug‐Induced Hyperthermia

1988 • 47 citations

Selective effects of LSD and hyperthemia on the synthesis of synaptic proteins and glycoproteins

1981 • 43 citations

Induction of heat shock protein 70 mRNA in adult hamster facial nuclear groups following axotomy of the facial nerve

1989 • 39 citations

Changes in chromatin and the phosphorylation of nuclear proteins during heat shock of Achlya ambisexualis.

1984 • 39 citations

A possible mechanism for the resorption of attachment plates in the growing rat brain

1974 • 37 citations

Time course of induction of a heat shock gene (hsp70) in the rabbit cerebellum after LSD in vivo: Involvement of drug-induced hyperthermia

1990 • 35 citations

The Brain 68‐Kilodalton Microtubule‐Associated Protein Is a Cognate Form of the 70‐Kilodalton Mammalian Heat‐Shock Protein and Is Present as a Specific Isoform in Synaptosomal Membranes

1986 • 35 citations

The major heat-shock protein (hsp70) gene family: related sequences in mouse, Drosophila, and yeast

1983 • 35 citations

Induction of the major inducible 68-kDa heat-shock protein after rapid changes of extracellular pH in cultured rat astrocytes

1989 • 34 citations

Remodeling of neuronal membranes as an early response to deafferentation. A freeze-fracture study.

1977 • 33 citations

Expression of heat shock genes in fetal and maternal rabbit brain

1985 • 32 citations

Comparison of labeled heat shock proteins in neuronal and non-neuronal cells of Aplysia californica

1985 • 32 citations

A retinal heat shock protein is associated with elements of the cytoskeleton and binds to calmodulin

1986 • 31 citations

ANALYSIS OF PROTEIN SYNTHESIS IN THE MAMMALIAN BRAIN USING LSD AND HYPERTHERMIA AS EXPERIMENTAL PROBES

1982 • 31 citations

Cellular localization of heat shock gene expression in rabbit cerebellum by in situ hybridization with plastic-embedded tissue

1989 • 31 citations

Protein synthesis in the mammalian retina following the intravenous administration of LSD

1982 • 24 citations

Effect of Intravenous Administration of d‐Lysergic Acid Diethylamide on Subsequent Protein Synthesis in a Cell‐Free System Derived from Brain

1981 • 23 citations

Effect of Intravenous Administration of D‐Lysergic Acid Diethylamide on Initiation of Protein Synthesis in a Cell‐Free System Derived from Brain

1984 • 21 citations

Altered expression of a heat shock protein in the mammalian nervous system in the presence of agents which affect microtubule stability

1987 • 19 citations

Effect of Hyperthermia and LSD on Gene Expression in the Mammalian Brain and Other Organs

1985 • 15 citations

Induction of a heat shock protein in the isolated mammalian retina

1986 • 14 citations

Characterization of a Translational Inhibitor Isolated from Rabbit Brain Following Intravenous Administration of d‐Lysergic Acid Diethylamide

1986 • 9 citations

Effects on in vitro brain protein synthesis of a translational inhibitor isolated from rabbit brain following intravenous administration of LSD

1987 • 9 citations

Induction of the 68/72 kDa Heat-Shock Protein during Hydrogen Peroxide Toxicity

1988 • 8 citations

Heat Stress Induces Changes in Protein Synthesis and Fast Axonal Transport in Bullfrog Sensory Neurons

1988 • 7 citations

Heat stress increases delivery of a unique sub‐population of proteins conveyed by fast axonal transport

1989 • 5 citations