ANALYSIS OF PROTEIN SYNTHESIS IN THE MAMMALIAN BRAIN USING LSD AND HYPERTHERMIA AS EXPERIMENTAL PROBES

Protein synthesis in salivary glands of Drosophila melanogaster: Relation to chromosome puffs

1974 • 1,189 citations

Selective heat sensitivity of cancer cells. Biochemical and clinical studies

1967 • 728 citations

Glossary of terms for thermal physiology.

1973 • 715 citations

Selective heat sensitivity of cancer cells. Biochemical and clinical studies

1967 • 653 citations

The effect of amino acid analogues and heat shock on gene expression in chicken embryo fibroblasts

1978 • 547 citations

Serotonin and lysergic acid diethylamide binding in rat brain membranes: relationship to postsynaptic serotonin receptors.

1976 • 494 citations

Dissociation of Mammalian Polyribosomes into Subunits by Puromycin

1971 • 432 citations

Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe

1968 • 396 citations

Histones and Nucleohistones

1995 • 325 citations

Selective Heat Sensitivity of Cancer Cells

1977 • 313 citations

Principles of medical pharmacology

1989 • 307 citations

Regulation of protein synthesis in HeLa cells: Translation at elevated temperatures

1969 • 302 citations

The Pharmacology of Thermoregulation

1973 • 273 citations

Resuscitation of the monkey brain after one hour complete ischemia. III. Indications of metabolic recovery

1975 • 232 citations

THE EFFECT OF ISCHAEMIA AND RECIRCULATION ON PROTEIN SYNTHESIS IN THE RAT BRAIN

1977 • 220 citations

Protein synthesis in the cat brain after prolonged cerebral ischemia

1971 • 184 citations

Inhibition of neurons in the amygdala by dorsal raphe stimulation: Mediation through a direct serotonergic pathway

1977 • 182 citations

A METHOD FOR MEASURING BRAIN PROTEIN SYNTHESIS RATES IN YOUNG AND ADULT RATS

1975 • 177 citations

The dopamine receptor: Differential binding of d-LSD and related agents to agonist and antagonist states

1975 • 165 citations

Breakdown and Reassembly of Rat Liver Ergosomes after Administration of Ethionine or Puromycin

1964 • 159 citations

Mechanisms, regulation and special functions of protein synthesis in the brain

1979 • 152 citations

A Brain-Cooling System in Mammals

1979 • 148 citations

Techniques in Protein Biosynthesis.

1968 • 148 citations

Characterization of the messenger RNA released from L cell polyribosomes as a result of temperature shock

1972 • 144 citations

A kinetic model of protein synthesis. Application to hemoglobin synthesis and translational control.

1979 • 143 citations

Brain dysfunction in infantile febrile convulsions

1977 • 136 citations

The central neurology of mammalian thermoregulation

1979 • 135 citations

D-LSD binding to brain homogenates: Possible relationship to serotonin receptors

1974 • 131 citations

Hyperphenylalaninemia: Disaggregation of Brain Polyribosomes in Young Rats

1970 • 131 citations

Serotonin-sensitive adenylate cyclase activity in immature rat brain

1975 • 115 citations

Binding interactions of lysergic acid diethylamide and related agents with dopamine receptors in the brain.

1976 • 109 citations

Fever versus hyperthermia.

1979 • 107 citations

Psychotomimetic drugs and brain 5-hydroxytryptamine metabolism

1970 • 105 citations

Topographical distribution of dopaminergic innervation and of dopaminergic receptors in the rat striatum. II. Distribution and characteristics of dopamine adenylate cyclase — Interaction of d-LSD with dopaminergic receptors

1976 • 102 citations

Effect of phenylalanine on protein synthesis in the developing rat brain

1970 • 99 citations

Aetiology and Pathophysiology of Malignant Hyperthermia

1987 • 98 citations

LSD as an agonist and antagonist at central dopamine receptors

1974 • 93 citations

Electroshock Effects on Brain Protein Synthesis: Relation to Brain Seizures and Retrograde Amnesia

1971 • 90 citations

DEVELOPMENTAL EFFECTS ON PROTEIN SYNTHESIS RATES IN REGIONS OF THE CNS IN VIVO AND IN VITRO

1977 • 88 citations

Protein synthesis in rabbit reticulocytes: mechanism of protein synthesis inhibition by heme-regulated inhibitor.

1979 • 74 citations

Coma, Hyperthermia, and Bleeding Associated with Massive LSD Overdose a Report of Eight Cases

1975 • 74 citations

POLYRIBOSOME DISAGGREGATION AND CELL‐FREE PROTEIN SYNTHESIS IN PREPARATIONS FROM CEREBRAL CORTEX OF HYPERPHENYLALANINEMIC RATS¹

1971 • 72 citations

The effects of hyperthermia (42°C) on the biochemistry and growth of a malignant cell line

1972 • 68 citations

Lysergic Acid Diethylamide: Role in Conversion of Plasma Tryptophan to Brain Serotonin (5-Hydroxytryptamine)

1969 • 68 citations

Etiology and Pathophysiology of Malignant Hyperthermia

1979 • 65 citations

Ethanol and brain protein synthesis

1971 • 64 citations

L-Dopa: Disaggregation of Brain Polysomes and Elevation of Brain Tryptophan

1971 • 62 citations

5-hydroxytryptamine binding to synaptic membranes from rat brain

1976 • 62 citations

Regulation of Protein Synthesis in Developing Mouse Brain Tissue

1970 • 61 citations

The mechanism of polyribosome disaggregation in brain tissue by phenylalanine

1975 • 60 citations

REGULATION OF PROTEIN SYNTHESIS DURING POSTNATAL MATURATION OF THE BRAIN

1976 • 57 citations

Changes in brain polyribosomes following an electro‐convulsive seizure

1970 • 56 citations

Translational control of protein synthesis

1971 • 56 citations

Stereospecific receptor sites for d-lysergic acid diethylamide in rat brain: effects of neurotransmitters, amine antagonists, and other psychotropic drugs.

1976 • 54 citations

Cerebral Protein Synthesis

1971 • 53 citations

Effects of excess phenylalanine onin vitro andin vivo RNA and protein synthesis and polyribosome levels in brains of mice

1971 • 53 citations

Age-dependent changes in brain protein synthesis in the rat

1980 • 53 citations

THE EFFECT OF ELECTROCONVULSIVE SHOCK ON PROTEIN SYNTHESIS IN MOUSE BRAIN

1971 • 49 citations

The effect of the administration of morphine on the incorporation of [14C]leucine into the proteins of rat brainin vivo

1967 • 47 citations

Hormonal regulation of brain development. IV. Effect of neonatal thyroidectomy upon incorporationin vivo ofl-[3H]phenylalanine into proteins of developing rat cerebral tissues and pituitary gland

1971 • 46 citations

ROLE OF RIBONUCLEASE ACTION IN PHENYLALANINE‐INDUCED DISAGGREGATION OF RAT CEREBRAL POLYRIBOSOMES

1976 • 46 citations

ALTERATION IN MICROSOMAL PROTEIN SYNTHESIS DURING EARLY DEVELOPMENT OF MOUSE BRAIN

1969 • 44 citations

Pyretogenic Effect of Lysergic Acid Diethylamide

1954 • 44 citations

Selective effects of LSD and hyperthemia on the synthesis of synaptic proteins and glycoproteins

1981 • 43 citations

EFFECTS OF CHRONIC ETHANOL INGESTION ON BRAIN AMINOACYL‐tRNA SYNTHETASES AND tRNA

1975 • 42 citations

Effect of elevated potassium level and amino acid deprivation on polysome distribution and rate of protein synthesis in L cells

1973 • 42 citations

DISAGGREGATION OF BRAIN POLYSOMES AFTER ADMINISTRATION OF d‐LYSERGIC ACID DIETHYLAMIDE (LSD) IN VIVO

1976 • 42 citations

Protein synthesis by membrane-bound and free ribosomes of the developing rat cerebral cortex

1971 • 41 citations

Dopamine: Mediator of Brain Polysome Disaggregation after L-Dopa

1972 • 40 citations

CHANGES IN POLYSOMES OF THE DEVELOPING RAT BRAIN

1970 • 40 citations

Experimentally induced and natural recovery from the effects of phenylalanine on brain protein synthesis

1978 • 40 citations

GROWTH AND DEVELOPMENT OF THE BRAIN IN NORMAL AND HEAT‐RETARDED GUINEA‐PIGS

1976 • 40 citations

The selective effect of actinomycin D on free polyribosomes of mouse liver

1969 • 38 citations

FURTHER EVALUATION OF POLYPEPTIDE SYNTHESIS IN CEREBRAL ANOXIA, HYPOXIA AND ISCHEMIA

1978 • 38 citations

EFFECTS OF ACUTE HYPERTHERMIA ON POLYRIBOSOMES, IN VIVO PROTEIN SYNTHESIS AND ORNITHINE DECARBOXYLASE ACTIVITY IN THE NEONATAL RAT BRAIN

1979 • 37 citations

Extreme Hyperthermia After LSD Ingestion

1971 • 37 citations

The regulatory parameter of protein synthesis most affected by ethionine, and cycloheximide

1972 • 37 citations

Conservation of globin messenger RNA in rabbit reticulocyte monoribosomes after sodium fluoride treatment

1972 • 36 citations

Amino Acid Incorporation into Rat Brain Proteins during Spreading Cortical Depression

1969 • 35 citations

EFFECTS OF EPILEPTIC SEIZURES ON BRAIN RIBOSOMES: MECHANISM AND RELATIONSHIP TO CEREBRAL ENERGY METABOLISM

1977 • 34 citations

Temperature regulation in the exercising rabbit

1973 • 33 citations

Protein Synthesis in a Cell‐free System from Rat Brain Sensitive to ACTH‐like Peptides

1980 • 33 citations

ON THE MECHANISM OF ELECTROSHOCK-INDUCED INHIBITION OF PROTEIN SYNTHESIS IN RABBIT CEREBRAL CORTEX

1977 • 32 citations

Disaggregation of brain polysomes after LSD in vivo

1979 • 32 citations

Hyperthermia and disaggregation of brain polysomes induced by bacterial pyrogen

1979 • 32 citations

LSD: Autoradiographic Study on the Placental Transfer and Tissue Distribution in Mice

1969 • 32 citations

Mechanism of d-amphetamine inhibition of protein synthesis

1976 • 31 citations

ACTIVITY OF CYCLIC AMP‐DEPENDENT MICROSOMAL PROTEIN KINASE AND PHOSPHORYLATION OF RIBOSOMAL PROTEIN IN RAT BRAIN DURING POSTNATAL DEVELOPMENT

1973 • 31 citations

Alterations in cell free brain protein synthesis following ethanol withdrawal in physically dependent rats

1977 • 30 citations

Cell‐Free Translation of Free and Membrane‐Bound Polysomes and Polyadenylated mRNA from Rabbit Brain Following Administration of d‐Lysergic Acid Diethylamide In Vivo

1981 • 30 citations

In vitro polypeptide synthesis in brain

1969 • 30 citations

Phosphorylation of ribosomal proteins in rat cerebral cortex in vitro.

1975 • 30 citations

Disaggregation of brain polysomes by L-5-hydroxytryptophan: Mediation by serotonin

1973 • 29 citations

D-amphetamine disaggregates brain polysomes via a dopaminergic mechanism.

1975 • 29 citations

Hemoglobin Synthesis at Elevated Temperatures

1972 • 29 citations

INFLUENCE DE LA DEFICIENCE THYROIDIENNE SUR L'INCORPORATION IN VIVO DE LA l-[³H]LEUCINE DANS LES PROTEINES DU CERVELET CHEZ LE JEUNE RAT THE EFFECT OF THYROID DEFICIENCY ON THE INCORPORATION OF l-[³H]LEUCINE INTO PROTEINS OF THE CEREBELLUM IN THE YOUNG RAT

1970 • 29 citations

The effects of hyperthermia on polyribosomes and amino acid levels in infant rat brain

1978 • 28 citations

Dissociation of rat brain polyribosomesin vivo by amphetamines

1975 • 28 citations

EXPERIMENTAL MATERNAL HYPERPHENYLALANINEMTA: DISAGGREGATION OF FETAL BRAIN RIBOSOMES

1973 • 27 citations

Effect of morphine on the turnover and synthesis of (LEU3H)-protein and (Ch14C)-phosphatidylcholine in discrete regions of the rat brain

1974 • 27 citations

The effect of LSD and 2-bromo LSD on the striatal DOPA accumulation after decarboxylase inhibition in rats

1977 • 27 citations

PROTEIN SYNTHESIS BY HIGHLY AGGREGATED AND PURIFIED POLYSOMES FROM YOUNG AND ADULT RAT BRAIN

1973 • 26 citations

Electrophysiological evidence for a dopaminergic action of LSD: Depression of unit activity in the substantia nigra of the rat

1977 • 26 citations

EFFECTS OF ELECTROCONVULSIVE SHOCK AND CYCLOHEXIMIDE ON THE INCORPORATION OF AMINO ACIDS INTO PROTEINS OF MOUSE BRAIN SUBCELLULAR FRACTIONS¹

1976 • 26 citations

Studies on the effects of chronic ethanol ingestion on the properties of rat brain ribosomes

1978 • 25 citations

BRAIN RIBOSOMES IN INTRACRANIAL HYPERTENSION¹

1974 • 25 citations

Protection against stress-induced brain norepinephrine depletion after repeated 2-deoxy-D-glucose administration

1977 • 25 citations

THE PERMISSIVE ROLE OF HYPERTHERMIA IN THE DISAGGREGATION OF BRAIN POLYSOMES BY <scp>l</scp>‐DOPA OR <scp>d</scp>‐AMPHETAMINE¹

1977 • 25 citations

PARTICIPATION OF DOPAMINE‐ AND SEROTONIN‐RECEPTORS IN THE DISAGGREGATION OF BRAIN POLYSOMES BY <scp>l</scp>‐DOPA AND <scp>l</scp>‐5‐HTP

1975 • 24 citations

Intracerebral injections inhibit amino acid incorporation into brain protein

1975 • 24 citations

IN VIVO INHIBITION OF RAT BRAIN PROTEIN SYNTHESIS BY <scp>l</scp>‐DOPA

1974 • 24 citations

Effect of Intravenous Administration of d‐Lysergic Acid Diethylamide on Subsequent Protein Synthesis in a Cell‐Free System Derived from Brain

1981 • 23 citations

RNA synthesis in isolated brian nuclei after administration of d-lysergic acid diethylamide (LSD) in vivo.

1975 • 22 citations

FETAL DEVELOPMENT: THE EFFECTS OF MATURATION ON IN VITRO PROTEIN SYNTHESIS BY MOUSE BRAIN TISSUE

1974 • 22 citations

Effect of Intravenous Administration of D‐Lysergic Acid Diethylamide on Initiation of Protein Synthesis in a Cell‐Free System Derived from Brain

1984 • 21 citations

PROTEIN TURNOVER DURING MATURATION OF MOUSE BRAIN TISSUE

1972 • 21 citations

EFFECTS OF SPREADING CORTICAL DEPRESSION ON THE INCORPORATION OF [¹⁴C]LEUCINE INTO PROTEINS OF RAT BRAIN

1970 • 20 citations

TRANSFER RNA AND THE REGULATION OF PROTEIN SYNTHESIS IN RAT CEREBRAL CORTEX DURING NEURAL DEVELOPMENT

1974 • 20 citations

A simple, reproducible cell-free system for measuring brain protein synthesis

1980 • 20 citations

Brain protein synthesis during neonatal seizures: An experimental study

1979 • 20 citations

Isolation of axonally transported glycoproteins with goldfish visual system myelin

1975 • 20 citations

Lysergic Acid Diethylamide: Effect on Histone Acetylation in Rabbit Brain

1975 • 19 citations

Characterization of an Initiating Cell‐Free Protein Synthesis System Derived from Rabbit Brain

1981 • 19 citations

DISAGGREGATION OF BRAIN POLYSOMES AFTER <scp>d</scp>‐LYSERGIC ACID DIETHYLAMIDE ADMINISTRATION IN VIVO: MECHANISM AND EFFECT OF AGE AND ENVIRONMENT¹

1977 • 19 citations

Antipsychotic drugs block LSD-induced disaggregation of brain polysomes

1977 • 19 citations

Defective initiation on natural messenger RNA by cell free systems from Krebs ascites cells incubated at elevated temperatures

1975 • 18 citations

BRAIN PROTEINS: QUALITATIVE AND QUANTITATIVE CHANGES, SYNTHESIS AND DEGRADATION DURING FETAL DEVELOPMENT OF THE RABBIT

1972 • 18 citations

The effects of haloperidol and thioridazine on apomorphine- and LSD-induced hyperthermia in the rabbit

1975 • 17 citations

The use of aminoacyl-tRNA to measure polypeptide synthesis by ribosomes isolated from neonatal and adult mouse brain tissue

1972 • 16 citations

DISAGGREGATION OF POLYSOMES IN FETAL ORGANS AND MATERNAL BRAIN AFTER ADMINISTRATION OF d‐LYSERGIC ACID DIETHYLAMIDE IN VIVO

1979 • 16 citations

Fate of mRNA following disaggregation of brain polysomes after administration of (+)-lysergic acid diethylamide in vivo

1979 • 15 citations

EFFECTS OF AMPHETAMINE ADMINISTRATION IN VIVO ON IN VITRO PROTEIN SYNTHESIZING SYSTEM FROM RAT BRAIN ¹

1976 • 15 citations

Uptake into brain proteins of 35S-methionine during morphine tolerance.

1975 • 14 citations

THE INFLUENCE OF SEROTONIN, D‐LYSERGIC ACID DIETHYLAMIDE AND 2‐BROM‐LSD ON THE INCORPORATION OF [³⁵S]METHIONINE INTO BRAIN PROTEINS AND ON THE LEVEL OF ATP IN THE BRAIN*

1961 • 14 citations

THE EFFECT OF MORPHINE TOLERANCE and DEPENDENCE ON CELL FREE PROTEIN SYNTHESIS¹

1978 • 14 citations

Hyperthermic effects of D-lysergic acid diethylamide (LSD) and its derivatives in rabbits and rats.

1977 • 14 citations

IN VIVO INHIBITION OF RAT BRAIN PROTEIN SYNTHESIS BY d‐AMPHETAMINE

1978 • 13 citations

Quantitation and localization of globin messenger RNA in rabbit reticulocyte lysate.

1979 • 12 citations

Inhibition of cell-free protein synthesis initiation by amphetamine: Association with reduction in tRNA aminoacylation

1977 • 12 citations

Differential responses of free and bound polysomes to inhibitors and neuroactive substances in vitro

1972 • 12 citations

Comparison of the Effect of Intravenous Administration of d‐Lysergic Acid Diethylamide on Free and Membrane‐Bound Polysomes in the Rabbit Brain

1981 • 11 citations

Lysergic acid diethylamide antagonism by chlorpromazine, haloperidol, diazepam, and pentobarbital in the rabbit

1977 • 11 citations

Stress-accentuation of the LSD-induced disaggregation of brain polysomes

1978 • 10 citations

Formation of ribosome dimers in brains of hypothermic rats

1971 • 9 citations

Effects of acute and chronic morphine administration on the incorporation of (3H)-lysine into mouse brain and liver proteins.

1974 • 8 citations

On the unique dissociability of neonatal rat cerebral free polysomes and changes during development of the brain

1974 • 6 citations

Alterations in number and activity of cerebral free and membrane-bound ribosomes after prolonged ethanol ingestion by the weanling rat

1979 • 6 citations

Influence of morphine on protein synthesis in discrete subcellular fractions of the rat brain.

1976 • 6 citations

THE INFLUENCE OF PRENATAL X‐IRRADIATION ON THE ACTIVITY OF sRNA‐AMTNOACYL SYNTHETASES IN THE DEVELOPING RABBIT BRAIN

1976 • 6 citations

The effect of morphine tolerance on the incorporation of ³H‐leucine into proteins of rat synaptic membranes

1979 • 6 citations

Protection by cycloheximide from hyperthermic inhibition of protein synthesis in human reticulocytes

1977 • 5 citations

Reversal of amphetamine induced polysome dissociation by neuroleptic agents in rat brain

1977 • 2 citations

Effect of crowding on amphetamine-induced disaggregation of brain polyribosomes.

1979 • 2 citations