Robust ability of IFN-γ to upregulate class II MHC antigen expression in tumor bearing rat brains

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Immunotherapy of Diffuse Gliomas: Biological Background, Current Status and Future Developments

2009 • 3,897 citations

Angiogenic Factors

1987 • 3,702 citations

Differentiated Rat Glial Cell Strain in Tissue Culture

1968 • 1,480 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Microglia: Intrinsic immuneffector cell of the brain

1995 • 1,099 citations

Youmansʼ Neurological Surgery

1990 • 1,079 citations

Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells

1987 • 648 citations

Adoptive T Cell Therapy of Tumors: Mechanisms Operative in the Recognition and Elimination of Tumor Cells

1991 • 619 citations

Rat brain tumor models in experimental neuro-oncology: the 9L, C6, T9, F98, RG2 (D74), RT-2 and CNS-1 gliomas.

1998 • 354 citations

Distribution and characterization of microglia/macrophages in human brain tumors

1996 • 313 citations

Monoclonal antibody analysis of MHC expression in human brain biopsies: tissue ranging from "histologically normal" to that showing different levels of glial tumor involvement.

1986 • 230 citations

Bulk flow of interstitial fluid after intracranial injection of Blue Dextran 2000

1974 • 213 citations

Directional and compartmentalised drainage of interstitial fluid and cerebrospinal fluid from the rat brain

1992 • 195 citations

Monocyte chemoattractant protein-1 expression and macrophage infiltration in gliomas

1997 • 178 citations

Morphological studies of rat brain tumors induced by N-nitrosomethylurea

1971 • 175 citations

A Histologic and Cytologic Method for the Spatial Definition of Gliomas

1987 • 166 citations

Clinical patterns of failure following stereotactic interstitial irradiation for malignant gliomas

1990 • 150 citations

Human astrocytomas and glioblastomas express monocyte chemoattractant protein‐1 (MCP‐1) in vivo and in vitro

1994 • 144 citations

Activation of naive, memory and effector T cells

1994 • 141 citations

Human Glioma-Induced Immunosuppression Involves Soluble Factor(s) That Alters Monocyte Cytokine Profile and Surface Markers

1999 • 140 citations

Immune modulation within the brain: recruitment of inflammatory cells and increased major histocompatibility antigen expression following intracerebral injection of interferon-γ

1991 • 136 citations

Central Nervous System Microglial Cell Activation and Proliferation Follows Direct Interaction with Tissue-Infiltrating T Cell Blasts

1998 • 135 citations

Major histocompatibility complex antigen expression in the affected tissues in amyotrophic lateral sclerosis

1990 • 125 citations

Interpreting MHC class I expression and class I/class II reciprocity in the CNS: Reconciling divergent findings

1995 • 105 citations

Malignant cerebral glioma

1990 • 86 citations

The role of surface HLA-A,B,C molecules in tumour immunity.

1992 • 60 citations

Exploiting the lacZ reporter gene for quantitative analysis of disseminated tumor growth within the brain: use of the lacZ gene product as a tumor antigen, for evaluation of antigenic modulation, and to facilitate image analysis of tumor growth in situ.

1993 • 59 citations

Effects of γ-interferon on major histocompatibility complex antigen expression and lymphocytic infiltration in the 9L gliosarcoma brain tumor model: implications for strategies of immunotherapy

1992 • 56 citations

Therapy of Cancer Metastasis by Tumoricidal Activation of Tissue Macrophages Using Liposome-Encapsulated Immunomodulators

1998 • 53 citations

In vivo antigen presentation by both brain parenchymal cells and hematopoietically derived cells during the induction of experimental autoimmune encephalomyelitis.

1993 • 52 citations

In vitro analysis of the proliferative potential of T cells from patients with brain tumor: glioma-associated immunosuppression unrelated to intrinsic cellular defect

1992 • 44 citations

Site-specific immune regulation in the brain: Differential modulation of major histocompatibility complex (MHC) proteins in brainstem vs. hippocampus

1999 • 43 citations

Disseminating tumor cells and their interactions with leukocytes visualized in the brain.

1992 • 34 citations

Intracerebral delayed hypersensitivity reactions in glioblastoma multiforme patients

1977 • 33 citations

Human microglia activate lymphoproliferative responses to recall viral antigens

1996 • 31 citations

Glioblastoma-associated circulating monocytes and the release of epidermal growth factor

1996 • 28 citations

New animal models to probe brain tumor biology, therapy, and immunotherapy: advantages and remaining concerns.

2001 • 28 citations

Beyond inflammation: site-directed immunotherapy

1998 • 20 citations

Immunogenetic and immunologic aspects of gliosarcoma growth in rats.

1983 • 18 citations

MHC expression in nonlymphoid tissues of the developing embryo: Strongest class I or class II expression in separate populations of potential antigen-presenting cells in the skin, lung, gut, and inter-organ connective tissue

1995 • 15 citations

Enhanced T Cell Migration to Sites of Microscopic CNS Disease: Complementary Treatments Evaluated by 2‐ and 3‐D Image Analysis

1994 • 14 citations

Activated monocytes kill malignant brain tumor cellsin vitro

1994 • 12 citations

A SURVEY OF ETHYLNITROSOUREA‐INDUCED RAT GLIOMAS FOR THE PRESENCE OF TUMOUR REJECTION ANTIGENS EXPRESSED IN VIVO

1981 • 9 citations

The Phagocyte in Human Gliomas

1997 • 6 citations

Similar Ligand Densities Required for Restimulation and Effector Function of Cytotoxic T Cells

1997 • 4 citations

Animal Models for Brain Tumor

2001 • 3 citations