Depression and antidepressant therapy: Receptor dynamics

Long-Term Antidepressant Treatment Decreases Spiroperidol-Labeled Serotonin Receptor Binding

1980 • 840 citations

Development of β-adrenergic receptor subsensitivity by antidepressants

1977 • 727 citations

Selective Amplification And Cloning Of Four New Members Of The G Protein-coupled Receptor Family

1989 • 647 citations

Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain

1975 • 599 citations

Tricyclic Antidepressants: Long-Term Treatment Increases Responsivity of Rat Forebrain Neurons to Serotonin

1978 • 476 citations

Serotonin function in anxiety

1987 • 467 citations

Modifications of the Serotonin System by Antidepressant Treatments

1987 • 413 citations

Characterization of a novel 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes

1987 • 406 citations

Zur Serotonin-Hypothese der Depression*

1990 • 397 citations

Quantitative autoradiography of beta 1- and beta 2-adrenergic receptors in rat brain.

1984 • 349 citations

Effects of antidepressant drugs on different receptors in the brain

1981 • 325 citations

Inhibition of the uptake of tritiated 5-hydroxytryptamine in brain tissue

1969 • 321 citations

Typical and atypical antidepressants. Molecular mechanisms.

1982 • 315 citations

Structure of the Adrenergic and Related Receptors

1989 • 300 citations

Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat.

1984 • 299 citations

Serotonergic Function in Depression

1984 • 280 citations

Differentiation of cardiac chronotropic and inotropic effects of ?-adrenoceptor agonists

1977 • 260 citations

Adrenergic Receptor Sensitivity in Depression

1982 • 253 citations

Differential effects of electroconvulsive shock and antidepressant drugs on serotonin-2 receptors in rat brain

1981 • 237 citations

Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression

1987 • 230 citations

Differential effects of antidepressant treatment on brain monoaminergic receptors

1980 • 222 citations

Molecular biology of 5-HT receptors

1989 • 214 citations

Adrenergic and serotonergic receptor binding in rat brain after chronic desmethylimipramine treatment.

1979 • 211 citations

5-Hydroxytryptamine-stimulated inositol phospholipid hydrolysis in rat cerebral cortex slices: pharmacological characterization and effects of antidepressants.

1985 • 198 citations

Serotonin receptor sensitivity after acute and chronic treatment with mianserin.

1982 • 188 citations

Action of mianserin and zimelidine on the norepinephrine receptor coupled adenylate cyclase system in brain: Subsensitivity without reduction in β-adrenergic receptor binding

1980 • 178 citations

Long-term 5-HT reuptake blockade, but not monoamine oxidase inhibition, decreases the function of terminal 5-HT autoreceptors: an electrophysiological study in the rat brain

1988 • 177 citations

Potential antidepressant properties of 8-hydroxy-2-(di-n-propylamino) tetralin, a selective serotonin1A receptor agonist

1987 • 163 citations

MECHANISM OF THE ANTIDEPRESSANT ACTION OF ELECTROCONVULSIVE THERAPY

1978 • 160 citations

Chronic antidepressant therapy and associated changes in central monoaminergic receptor functioning

1983 • 160 citations

Further observations on the effect of repeated electroconvulsive shock on the behavioural resposes of rats produced by increases in the functional activity of brain 5-hydroxytryptamine and dopamine

1977 • 155 citations

Effects of Biogenic Amines and TRH on Release of Prolactin and TSH in the Rat¹

1975 • 147 citations

Serotonin Function and Mechanism of Action of Antidepressant Treatment

1984 • 143 citations

Brain noradrenaline depletion prevents ECS-induced enhancement of serotonin-and dopamine-mediated behaviour

1980 • 139 citations

α1-adrenoceptor-mediated responses in the lateral geniculate nucleus are enhanced by chronic antidepressant treatment

1981 • 130 citations

Beta-adrenergic receptor function in affective illness

1979 • 130 citations

Chronic antidepressant treatment enhances α-adrenergic and serotonergic responses in the facial nucleus

1980 • 120 citations

Modifications of central 5-hydroxytryptamine binding sites in synaptic membranes from rat brain after long-term administration of tricyclic antidepressants

1979 • 119 citations

Enhancement of responsiveness of the central serotonergic system and serotonin-2 receptor density in rat frontal cortex by electroconvulsive treatment

1981 • 119 citations

Changes in lymphocyte beta-adrenergic receptors in depression and mania

1979 • 117 citations

Enhanced sensitivity of amygdaloid neurons to serotonin and norepinephrine after chronic antidepressant treatment.

1980 • 107 citations

Detection and Characterization of the Serotonin 5-HT_1DReceptor in Rat and Human Brain

1988 • 106 citations

Effects of the two antidepressant drugs mianserin and indalpine on the serotonergic system: Single-cell studies in the rat

1984 • 97 citations

Heterologous Expression of Excitability Proteins: Route to More Specific Drugs?

1988 • 95 citations

The effect of tri-iodothyronine in combination with imipramine on [3H]-cyclic AMP production in slices of rat cerebral cortex

1974 • 92 citations

STRUCTURE ACTIVITY RELATIONS FOR THE INHIBITION OF 5‐HT UPTAKE INTO RAT HYPOTHALAMIC HOMOGENATES BY SEROTONIN AND TRYPTAMINE ANALOGUES

1973 • 89 citations

The effect of acute and chronic desipramine and amitriptyline treatment on rat brain total 3-methoxy-4-hydroxyphenylglycol

1978 • 89 citations

Differential effect of chronic desipramine and amitriptyline treatment on rat brain adrenergic and serotonergic receptors

1981 • 84 citations

Open trial of buspirone in the treatment of major depressive disorder.

1986 • 83 citations

Intact presynaptic terminals required for beta-adrenergic receptor regulation by desipramine

1979 • 82 citations

Monoamine oxidase inhibitors and serotonin uptake inhibitors: differential effects on [3H]serotonin binding sites in rat brain.

1980 • 82 citations

Responses of prolactin and growth hormone to L-tryptophan infusion: Effects in normal subjects and schizophrenic patients receiving neuroleptics

1985 • 76 citations

The effect of lithium on 5-HT-mediated neuroendocrine responses and platelet 5-HT receptors

1986 • 75 citations

Enhanced serotonin receptor activity after chronic treatment with imipramine or amitriptyline.

1979 • 72 citations

Pre‐ and postsynaptic effects of zimelidine and norzimelidine on the serotoninergic system: single cell studies in the rat

1981 • 72 citations

Mianserin, danitracen and amitriptyline withdrawal increases the behavioural responses of rats to L-5-HTP

1979 • 66 citations

Chapter 26 Serotonin receptor subtypes and the modulation of pain transmission

1988 • 63 citations

Clomipramine enhances prolactin and growth hormone responses to l-tryptophan

1986 • 62 citations

Effects of clenbuterol on central beta-1 and beta-2 adrenergic receptors of the rat.

1987 • 61 citations

Is it possible to modify serotonin receptor sensitivity?

1978 • 59 citations

Selective serotonin1A/1B agonists differentially affect spinal nociceptive reflexes

1990 • 53 citations

Interaction of beta adrenergic agonists and antagonists with brain beta adrenergic receptors in vivo.

1987 • 50 citations

Effect of antidepressants, lithium and electroconvulsive treatment on rat serum prolactin levels

1981 • 50 citations

Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression

1984 • 49 citations

Interactions of trazodone with serotonin neurons and receptors

1984 • 48 citations

Differential effects of monoamine oxidase inhibitors and serotonin reuptake inhibitors on 3H-serotonin receptor binding in rat brain

1979 • 48 citations

Hormonal and behavioral effects associated with intravenousl-tryptophan administration

1986 • 40 citations

Interaction of Antidepressants with Brain Neurotransmitter Receptors

1981 • 40 citations

Biochemical hypotheses on antidepressant drugs: a guide for clinicians or a toy for pharmacologists?

1988 • 40 citations

Effects of tranylcypromine treatment on neuroendocrine, behavioral, and autonomic responses to tryptophan in depressed patients

1985 • 37 citations

Effects of clenbuterol and antidepressant drugs on beta adrenergic receptor/N-protein coupling in the cerebral cortex of the rat.

1985 • 36 citations

Selective 5-HT1B agonists identify the 5-HT autoreceptor in lumbar spinal cord of rat

1988 • 36 citations

Daily bupropion injections for 3 weeks attenuate the ne-stimulation of adenylate cyclase and the number of β-adrenergic recognition sites in rat frontal cortex

1983 • 34 citations

Function of serotonin in physiologic secretion of growth hormone and prolactin: Action of 5,7-dihydroxytryptamine, fenfluramine and p-chlorophenylalanine

1982 • 32 citations

Synergistic interaction between α- and β -adrenergic receptors in rat brain slices: Possible site for antidepressant drug action

1985 • 30 citations

Labeling in vivo of beta adrenergic receptors in the central nervous system of the rat after administration of [125I] iodopindolol.

1985 • 29 citations

Selective regulation of beta-2 adrenergic receptors by the chronic administration of the lipophilic beta adrenergic receptor agonist clenbuterol: an autoradiographic study.

1987 • 27 citations

The effects of serotonin antagonists in a behavioral despair procedure in mice

1984 • 26 citations

Neurochemical and behavioral correlates of antidepressant drug action

1982 • 24 citations

Effects of trazodone treatment on serotonergic function in depressed patients

1988 • 22 citations

NEUROENDOCRINE STUDIES OF MAJOR DEPRESSIVE DISORDER

1980 • 22 citations

Identification of a novel 5-HT1 binding site in rat spinal cord

1990 • 20 citations

Functional change in the 5-HT presynaptic receptor in spinal cord of aged rats

1989 • 16 citations

Influence of a chronic new potential antidepressant, 1-[3-(dimethylamino)propyl]-5-methyl-3-phenyl-1H-indazole(FS32) and its N-Desmethylated compound(FS97): Treatment on monoaminergic receptor sensitivity in the rat brain

1981 • 16 citations

Interaction of quaternary phenothiazine salts with calmodulin.

1984 • 16 citations

Antidepressant administration has a differential effect on rat brain α2-adrenoceptor sensitivity to agonists and antagonists

1986 • 14 citations

Antidepressant drugs: effects on beta-adrenergic and serotonineregic receptors.

1982 • 5 citations

Hypnotic and hypothermic effect of pregnant mare urine extracts in the rat

1968 • 4 citations

Effects of prenalterol on beta adrenergic responsiveness and receptors in the cerebral cortex of the rat

1988 • 1 citations

Deleted Work

1955 • 0 citations