Tricyclic Antidepressants: Long-Term Treatment Increases Responsivity of Rat Forebrain Neurons to Serotonin

An animal behavior model for studying central serotonergic synapses

1976 • 555 citations

Inhibition of Uptake of Tritiated-noradrenaline in the Intact Rat Brain by Imipramine and Structurally Related Compounds

1964 • 506 citations

A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-Trifluoromethylphenoxy)-n-methyl-3-phenylpropylamine

1974 • 461 citations

Tryptophan hydroxylase inhibition: the mechanism by which p-chlorophenylalanine depletes rat brain serotonin.

1967 • 418 citations

GABA UPTAKE IN RAT CENTRAL NERVOUS SYSTEM: COMPARISON OF UPTAKE IN SLICES AND HOMOGENATES AND THE EFFECTS OF SOME INHIBITORS

1971 • 417 citations

A possible common mechanism of action of antidepressant treatments

1976 • 410 citations

Lysergic acid diethylamide and serotonin: a comparison of effects on serotonergic neurons and neurons receiving a serotonergic input.

1974 • 311 citations

Differential Response to Chlorpromazine, Imipramine, and Placebo

1970 • 302 citations

Catecholamine uptake by synaptosomes from rat brain. Structure-activity relationships of drugs with differential effects on dopamine and norepinephrine neurons.

1971 • 283 citations

Parachlorophenylalanine Reversal of Tranylcypromine Effects in Depressed Patients

1976 • 263 citations

Brain histamine receptors as targets for antidepressant drugs

1978 • 258 citations

Ascending projections of the locus coeruleus in the rat. I. axonal transport in central noradrenaline neurons

1977 • 224 citations

Serotonin-containing neuronal perikarya and terminals: differential effects of p-chlorophenylalanine

1973 • 199 citations

Tricyclic Antidepressant Agents. I. Comparison of the Inhibition of the Uptake of ³H‐Noradrenaline and ¹⁴C‐5‐Hydroxytryptamine in Slices and Crude Synaptosome Preparations of the Midbrain‐Hypothalamus Region of the Rat Brain

1975 • 198 citations

Inhibition of Serotonin Synthesis by Para-Chlorophenylalanine in Patients with the Carcinoid Syndrome

1967 • 191 citations

The Effects of Cocaine on Depressed Patients

1974 • 166 citations

Stereospecific binding ofd-lysergic acid diethylamide (LSD) to brain membranes: Relationship to serotonin receptors

1975 • 166 citations

Serotonergic innervation of the forebrain: Effect of lesions on serotonin and tryptophan hydroxylase levels

1977 • 163 citations

Use of synthesis inhibitors in defining a role for biogenic amines during imipramine treatment in depressed patients.

1975 • 156 citations

Accumulation of tritiated 5-hydroxytryptamine in brain slices

1967 • 131 citations

D-LSD binding to brain homogenates: Possible relationship to serotonin receptors

1974 • 131 citations

Psychoactive drug effects on a system which generates cyclic AMP in brain

1976 • 124 citations

Serotonin Now: Clinical Implications of Inhibiting Its Synthesis with Para-Chlorophenylalanine

1970 • 111 citations

Neurochemical and pharmacological studies on a new 5HT-uptake inhibitor, FG4963, with potential antidepressant properties

1975 • 87 citations

A neuronal receptor sensitivity mechanism in affective illness (a review of evidence).

1977 • 78 citations

Clinical‐pharmacological evaluation of p‐chlorophenylalanine: A new serotonin‐depleting agent

1966 • 78 citations

Tricyclic Antidepressant Agents. II. Effect of Oral Administration on the Uptake of ³H‐Noradrenaline and ¹⁴C‐5‐Hydroxytryptamine in Slices of the Midbrain‐Hypothalamus Region of the Rat

1975 • 78 citations

Antidepressant evaluation and the pharmacological actions of FG4963 in depressive patients

1977 • 72 citations

γ-Aminobutyric acid, bicuculline, and post-synaptic binding sites

1973 • 64 citations

EFFECTS OF IMIPRAMINE AND DESIPRAMINE ON RESPONSES OF SINGLE CORTICAL NEURONES TO NORADRENALINE AND 5‐HYDROXYTRYPTAMINE

1974 • 58 citations

LSD and 2-Bromo-Lsd: Comparison of effects on serotonergic neurones and on neurones in two serotonergic projection areas, the ventral lateral geniculate and amygdala

1976 • 52 citations

Pharmacologic Effects in Man of a Specific Serotonin-Reuptake Inhibitor

1978 • 45 citations

Norepinephrine-stimulated cyclic AMP accumulation in brain slices in vitro after serotonin depletion or chronic administration of selective amine reuptake inhibitors.

1977 • 40 citations

ISOLATION OF HYDROPHOBIC PROTEINS BINDING AMINO ACIDS: γ‐AMINOBUTYRIC ACID BINDING IN THE RAT CEREBRAL CORTEX

1975 • 40 citations

Effect of Iprindole on Amine Uptake in Man

1972 • 39 citations

Do tricyclic antidepressants enhance adrenergic transmission?

1977 • 37 citations

FACTORS THAT AFFECT THE BINDING AND UPTAKE OF GABA BY BRAIN TISSUE¹

1971 • 35 citations

Quantitative evaluation of responses to microiontophoretically applied drugs

1974 • 34 citations

Noradrenaline, depressive illness, and the action of amitriptyline

1977 • 31 citations

Vascular Supply of the Pituitary Gland in Channa punctatus Bloch

1965 • 29 citations

The interactions of tricyclic antidepressants with the biogenic amine uptake systems in the central nervous system.

1976 • 25 citations

On the pharmacology and biochemistry of the amine‐uptake mechanism in human blood platelets

1973 • 25 citations

EFFECT OF ANTIDEPRESSANT AND ANTIMANIC DRUGS ON AMINE UPTAKE IN MAN

1974 • 14 citations

REPEATED CHLORPROMAZINE ADMINISTRATION INCREASES A BEHAVIOURAL RESPONSE OF RATS TO 5‐HYDROXYTRYPTAMINE RECEPTOR STIMULATION

1977 • 13 citations

A THERAPEUTIC TRIAL IN MIGRAINE WITH PARACHLOROPHENYLALANINE, A SPECIFIC SEROTONIN DEPLETOR

1970 • 5 citations