Molecular biology of 5-HT receptors

Three-dimensional model of purple membrane obtained by electron microscopy

1975 • 2,259 citations

Identification of a Family of Muscarinic Acetylcholine Receptor Genes

1987 • 1,439 citations

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

1986 • 1,264 citations

Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

1986 • 917 citations

Chimeric α ₂ -,β ₂ -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity

1988 • 766 citations

Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

1987 • 766 citations

Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor

1988 • 691 citations

Selective Amplification And Cloning Of Four New Members Of The G Protein-coupled Receptor Family

1989 • 647 citations

A family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 636 citations

Palmitoylation of the human β2-adrenergic receptor

1989 • 599 citations

The binding of serotonergic ligands to the porcine choroid plexus: Characterization of a new type of serotonin recognition site

1984 • 598 citations

The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor

1988 • 594 citations

An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 509 citations

Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene.

1990 • 444 citations

A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system.

1988 • 435 citations

Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes.

1986 • 420 citations

Structure and functional expression of cloned rat serotonin 5HT-2 receptor.

1988 • 381 citations

Structural features required for ligand binding to the beta-adrenergic receptor.

1987 • 358 citations

Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain

1989 • 354 citations

Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence

1986 • 344 citations

Ligand binding to the β-adrenergic receptor involves its rhodopsin-like core

1987 • 318 citations

The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.

1990 • 280 citations

5-HT3 receptors mediate rapid responses in cultured hippocampus and a clonal cell line

1988 • 261 citations

Molecular pharmacology and biology of 5-HT1C receptors

1988 • 237 citations

Receptor reserve for 5-hydroxytryptamine1A-mediated inhibition of serotonin synthesis: possible relationship to anxiolytic properties of 5-hydroxytryptamine1A agonists.

1990 • 227 citations

5-HT1A-receptors mediate stimulation of adenylate cyclase in rat hippocampus

1986 • 197 citations

Detection of a Novel Serotonin Receptor Subtype (5‐HT_1E) in Human Brain: Interaction with a GTP‐Binding Protein

1989 • 176 citations

125I-lysergic acid diethylamide binds to a novel serotonergic site on rat choroid plexus epithelial cells

1985 • 159 citations

The use of Xenopus oocytes to probe synaptic communication

1988 • 138 citations

3H-DOB (4-bromo-2,5-dimethoxyphenylisopropylamine) labels a guanyl nucleotide-sensitive state of cortical 5-HT2 receptors.

1987 • 103 citations

Two 5-HT receptors linked to adenylate cyclase in guinea pig hippocampus are discriminated by 5-carboxamidotryptamine and spiperone

1985 • 102 citations

Heterologous Expression of Excitability Proteins: Route to More Specific Drugs?

1988 • 95 citations

Serotonin 5-HT1 receptors mediate inhibition of cyclic AMP production in neurons

1986 • 91 citations

Rat brain 5-HT1C receptors are encoded by a 5-6 kbase mRNA size class and are functionally expressed in injected Xenopus oocytes

1987 • 91 citations

BRL 24924: a potent agonist at a non-classical 5-HT receptor positively coupled with adenylate cyclase in colliculi neurons

1989 • 84 citations

Effector systems coupled to serotonin receptors in brain: serotonin stimulated phosphoinositide hydrolysis.

1986 • 30 citations

(R)-(-)-[77Br]4-bromo-2,5-dimethoxyamphetamine labels a novel 5-hydroxytryptamine binding site in brain membranes.

1988 • 21 citations